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1. Targeted delivery of gold nanoparticle contrast agents for reporting gene detection by magnetic resonance imaging.

Author

Vistain LF, Rotz MW, Rathore R, Preslar AT, and Meade TJ

Subjects
Cell Line, Chelating Agents pharmacokinetics, Contrast Media pharmacokinetics, DNA chemistry, Gadolinium pharmacokinetics, Gene Expression, Humans, Chelating Agents administration & dosage, Contrast Media administration & dosage, Gadolinium administration & dosage, Genes, Reporter, Gold chemistry, Magnetic Resonance Imaging methods, Metal Nanoparticles chemistry
Abstract

Detection of protein expression by MRI requires a high payload of Gd(III) per protein binding event. Presented here is a targeted AuDNA nanoparticle capable of delivering several hundred Gd(III) chelates to the HaloTag reporter protein. Incubating this particle with HaloTag-expressing cells produced a 9.4 contrast-to-noise ratio compared to non-expressing cells.

Published
2016
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