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[Display omitted] • GHPSM displayed enhanced accumulation and controlled drug release in OA cartilage site. • GHPSM delayed OA progression by reshaping OA microenvironment via multi-channel. • The progressions of early OA disease after treatments were tracked by fluorescence/MR imaging. Osteoarthritis (OA) is a degenerative joint disease of the knee joint, suffering from the limited therapeutic effect and serious side effects. Unfortunately, there are currently rarely available materials to fundamentally delay and monitor OA progression. The OA microenvironment, including excessive inflammation, matrix metalloproteinases (MMPs), oxidative stress, and reactive oxygen species (ROS), play a crucial role in the pathogenesis of OA. Utilizing and remodeling OA microenvironment may be an effective strategy for the diagnosis and treatment of OA. This work developed an intelligent responsive nanoprobe, Gd-HMPB@SMT@MMP (GHPSM) by encapsulating S-methylisothiourea (SMT) loaded mesoporous Prussian Blue (Gd-HMPB) with Tetramethyl Rhodamine (TAMRA) labeled MMP-13 peptide (MMP-13-TAMRA) for this aim. GHPSM displayed enhanced accumulation in OA cartilage site due to the decrease in the content of negatively charged aminoglycans (GAGs) in early degenerative articular cartilage and activated fluorescence signal as well as SMT controlled release due to the cleavage of MMP-13-TAMRA from GHPSM by overexpressed MMP-13 matrix protease in OA microenvironment. Furthermore, integrating the function of SMT and PB nanozyme, GHPSM reshaped the OA microenvironment by reducing the release of ROS and inflammatory factors (TNF-α, IL-6, iNOS), increasing the expression of intermediate structural proteins (COL2 and Aggrescan), thereby reducing cartilage degradation and chondrocyte apoptosis, ultimately delaying the development of OA. The progressions of early OA disease after different treatments were successfully tracked based on fluorescence/MR imaging with X-ray imaging of knee joint for comparation. These findings highlight the potentials of GHPSM in monitoring the status of cartilage in real-time and delay OA progression by reshaping the OA microenvironment, providing novel ideas for future research in OA diagnosis and treatment. [ABSTRACT FROM AUTHOR]

[Display omitted] • Fe(II) can provide electrons to promote the reduction of nitrite. • Fe(III) supported the growth and metabolism of P. JM-7 as an electron acceptor. • The higher growth and proliferation of P. JM-7 in iron-containing fillers. • The morphology of phosphate was similar to bidentate-bonded Fe–PO 4 complexes. • Administering Fe(II)/Fe(III) should consider their nucleation and crystallization. The interdependence between iron and nitrogen in the environment is of utmost importance, and this study has explored the intricate relationship between denitrification and iron valence cycling using Pseudomonas sp. strain JM-7 (P. JM-7) as a model bacteria. Our research demonstrated that P. JM-7 had the ability to effectuate electron transfer from the periplasmic space to electron acceptors, such as nitrate, via Cytochrome c -proteins (c-Cyts). We found that iron valence state transformations with Fe(II)/Fe(III) promoted P. JM-7′s denitrification of nitrate coupled to yeast extract powder (YEP) oxidation. Denitrification rates depended on temperature (>21 °C) and pH (6–9). During logarithmic growth, 5 g/L YEP enabled 350 mg/L nitrate removal, increasing to 1650 mg/L in stable growth. Addition of 4 mM Fe(II)/Fe(III) increased denitrification to 500 mg/L during logarithmic growth. The dynamic test results displayed that compared to the SiO 2 filler control group, iron-containing fillers could facilitate P. JM-7 to reduce 100 mg/L nitrate with 50 mg/L YEP electrons, corresponding to 6 times the maximum electron transfer efficiency in the static test. Overall, iron redox cycling significantly enhanced P. JM-7 denitrification, imparting insights into iron–nitrogen interactions. In summary, our research imparts valuable insights into the nexus between iron and nitrogen in the environment, highlighting the potential application of P. JM-7 in environmental engineering. Our findings indicate that P. JM-7 exhibits a significant denitrification capability, and further research is recommended to investigate its ability to remove phosphorus and promote sustainable environmental remediation practices. [ABSTRACT FROM AUTHOR]

• Z-scheme ZIS/BTO heterojunction with piezoelectric effect was synthesized. • ZIS/BTO heterojunction promoted charge separation and prolonged carrier lifetime. • Charge transfer mechanism was investigated by DFT calculations and experiments. • ZIS/BTO heterojunction exhibited significant CO yield under light and ultrasound. Converting CO 2 into high-value-added chemicals by artificial photosynthesis technology effectively solves environmental problems and energy shortages. Nevertheless, it remains challenging to improve CO 2 conversion rates due to low photo-utilization and rapid electron-hole recombination. In this study, we successfully synthesized direct Z-scheme ZnIn 2 S 4 /BaTiO 3 heterojunction structure by a hydrothermal method. Specifically, compared with previous studies of various heterojunction catalysts, ZnIn 2 S 4 /BaTiO 3 heterojunction structure achieved a remarkably high yield of 105.89 μmol g-1 h-1, increasing 2.55 and 3.62-fold over the individual performance of ZnIn 2 S 4 and BaTiO 3 , respectively. Our investigation of photocatalytic mechanism suggest that the improved photocatalytic CO 2 reduction performance can be attributed to the synergistic effects of the piezoelectric effect and Z-scheme electron transfer mechanism. These effects can synergistically enhance space charge separation and retain photogenerated electrons, thereby facilitating a more efficient CO 2 reduction process. Consequently, this innovative piezoelectric effect-assisted Z-scheme heterojunction demonstrates immense potential to offer a novel strategy for addressing CO 2 reduction challenges and advancing sustainable energy development. [ABSTRACT FROM AUTHOR]

An unprecedented SIB materials based C@NCS@V 4 C 3 T x with good cooperative interfaces was reported. Benefitting from the synergetic effects derived from the built cooperative interfaces, the C@NCS@V 4 C 3 T x hybrid exhibited an ultrahigh reversible specific capacity and the corresponding good reversible capacity, both higher than those of same kind batteries. Assembled full-cell delivers outstanding electrochemical properties that can be useful as a portable integrated unit for self-powered systems. [Display omitted] • Fewer layers of V 4 C 3 T x nanosheet sites are available for sodium storage. • A high-efficiency anode was designed by a pseudo-isotope synthesis strategy. • The full-cell shows high-rate and superior cycling performance. Materials used for conventional conversion-type anodes usually suffer from poor charge transfer and short lifespan, thereby limiting their utility in sodium-ion batteries (SIBs). To prevent these issues, the development of new anode materials is imperative. Herein, we used a synergistic modification strategy based on pseudo-isotopic substitution and 2D conductive skeleton support, to successfully prepare an unprecedented (Co 0.5 Ni 0.5)S 2 @V 4 C 3 T x with carbon layer coating (C@NCS@V 4 C 3 T x) anode materials for SIBs. We noted that the C@NCS@V 4 C 3 T x hybrid exhibited an ultrahigh reversible specific capacity of 705.6 mAh g−1 at 0.1 Ag−1, and the corresponding reversible capacity that is 100-times higher (10 A g−1) at a specific heat capacity of 347.6 mAh g−1, both higher than those of same kind batteries. Furthermore, the as-prepared hybrid also shows satisfactory long-term cycling stability, resulting from 2D skeleton V 4 C 3 T x MXene with high conductivity and robustness. Through in-situ characterization techniques and density functional theory calculations, the sodium ions storage mechanism was well-investigated, specifically, the synergy effect between the high capacity of bimetallic TMS and metallic conductivity and excellent stability of V 4 C 3 T x MXene plays an important role in high-performance achievement. Thus, assembled C@NCS@V 4 C 3 T x //Na 3 V 2 (PO 4) 3 full-cell delivers outstanding electrochemical properties that can be useful as a portable integrated unit for self-powered systems. [ABSTRACT FROM AUTHOR]

[Display omitted] • PAN/TiO 2 @PDA@BiOBr (PTPB-8) electrospun membrane is fabricated. • PTPB-8 has water contact angle of ∼ 0°/underwater oil contact angle of 154.7 ± 2.5°. • PTPB-8 exhibits good separation efficiency and reusability for emulsion separation. • TiO 2 @PDA@BiOBr is Z-scheme heterojunction with high photocatalytic efficiency. • PTPB-8 is capable of purifying biochemical oily wastewater with sunlight. Membrane separation technology is a promising alternative for oily wastewater purification. However, developing membrane for the purification of biochemical oily wastewater is still challengeable. To this aim, a novel multifunctional photocatalytic membrane of PTPB-8 is fabricated by sequentially loading of TiO 2 , polydopamine (PDA), and BiOBr onto polyacrylonitrile (PAN) nanofibers in situ. PTPB-8 is of water contact angle (WCA) ∼ 0° and underwater oil contact angle (UOCA) 154.7 ± 2.5°, allowing it with outstanding separation and anti-fouling capability, and good reusability for emulsion separation under gravity (i.e., separation efficiency >90 %, permeation flux >300 L m-2h−1, and flux recovery rate >82 % for n-hexane-in-water emulsion after 15 cycles). Under simulated solar light, the ternary heterojunction TiO 2 @PDA@BiOBr is catalytically active with generating active species and the charge transfer pathway follows the mechanism of Z-type heterojunction. Consequently, PTPB-8 can kill E. coli and S. aureus by ∼ 100 % and degrade tetracycline by >90 %. The application trial results have demonstrated the great potential of PTPB-8 in the purification of biochemical oily wastewater containing bacteria and antibiotics. This study will also give a new idea for enhancing the photocatalytic activity of heterojunctions by PDA decoration. [ABSTRACT FROM AUTHOR]

[Display omitted] • A Self-powered energy harvesting and implantable storage system was established. • The Mxene-based hydrogel with remarkable conductivity stretchability was explored. • This multi-functional hydrogel acted as the electrolyte of supercapacitor. • The hydrogel was also used as the electrode of triboelectric nanogenerator. The development of personalized and wearable devices has accelerated the investigation of flexible, biocompatible, and stretchable supercapacitors (SCs), enabling the integration into all-in-one integrated self-charging power packages. However, the most explored polyvinyl alcohol (PVA)-based gel electrolytes cannot well meet the requirements of stretchable and biocompatible SCs, mainly due to their inherently poor stretchable features. Herein, we report a new MXene-based polyacrylamide (PAM) hydrogel with high mechanical stretchability and excellent ionic conductivity. The hydrogel is utilized as the electrolyte of SCs and the electrode of self-powered triboelectric nanogenerator (TENG) simultaneously in the integrated self-charging power package. The SC exhibits good biocompatibility, high capacitance, high flexibility, and long-term stability, which is suitable for wearable energy storage devices and implanted electronic device. It can be implanted into rats with high biocompatibility. It has promising for use in portable, wearable, and implantable energy related devices. [ABSTRACT FROM AUTHOR]

This work fabricated highly flexible and piezoelectric nanofiber with coaxial and hierarchical architecture, which integrated polydopamine-modified BaTiO 3 nanowires into polymeric P(VDF-TrFE) matrix. The assembled flexible and wearable piezoelectric nanogenerator had excellent sensitivity and stability for self-powered physiological multimodal sensing. [Display omitted] • Development of organic–inorganic coaxial piezoelectric nanogenerator (PENG). • The reinforced interfacial coupling improved the piezoelectric response. • The mechanism of interfacial enhancement was deeply investigated. • High sensitivity (4.3 V N−1) and rapid response time (20.4 ms) were achieved. The relatively low sensitivity of flexible piezoelectric nanogenerators (PENG) is the most urgent problem to be solved for their applications in internet of things and artificial intelligences. To improve the piezoelectricity of polymeric fibers without discount of flexibility, BaTiO 3 nanowire (BTNW) with high aspect ratio is introduced into the piezoelectric P(VDF-TrFE) (denoted as PT) electrospun fibers to form coaxial composite nanofibers for improving the sensitivity towards external mechanical loads. To reinforce the organic–inorganic interfacial interaction for the improvement of the piezoelectric response, a nanolayer of polydopamine (PDA) is uniformly coated on the surface of BTNW (denoted as pBTNW) to form PT/pBTNW nanofibers. The introduction of 7 wt% pBTNW into the fibers significantly improves the polymeric β-phase conformation and mechanical properties, simultaneously, resulting in an optimal piezoelectric output of 18.2 V under an impact force of 5 N with excellent sensitivity of 4.3 V N−1. Through both theoretical simulation and experimental characterization, the PT/pBTNW-based PENG exhibits a higher electrical output than the equivalent nanoparticle-based PENG. The optimized PENG sensor can be used for self-powered and sensitive biomonitoring of physiological movements, finger identification and voice recognition. Overall, this work offers a reliable method for enhancing piezoelectricity of flexible polymeric nanofiber and designing high-performance PENG for wearable fabric-based sensors. [ABSTRACT FROM AUTHOR]

[Display omitted] • CoN@NC is prepared by a facile vaporization-nitridation synthesis strategy. • Hierarchical porous structure and coupling effect enhance electron/mass transport. • CoN@NC as a trifunctional catalyst can efficiently catalyze ORR/OER/HER. • CoN@NC demonstrates high performances in water splitting and Zn-air battery. Compositional and structural engineering of high-performance catalysts is vital for electrochemical catalysis, but challenges remain in their facile synthesis and efficient controls. Herein, a novel vaporization-nitridation synthesis strategy with simple operation is developed to prepare hierarchically porous cobalt nitride hybrid nanosheets grown on Ni foam by coupling cobalt nitride with N-doped carbon (CoN@NC). Benefitting from the highly open 3D hierarchical porous architecture and strong coupling effect between CoN and NC, the obtained CoN@NC electrode possesses accelerated ion and electron transfer. Moreover, the transform from CoN to CoOOH during water oxidation is confirmed by in-situ Raman characterizations, which together with NC and CoN species afford multiple active sites. The optimized CoN@NC-300 exhibits remarkable trifunctional catalytic activity towards OER, HER and ORR. Consequently, a two-electrode electrolyzer based on CoN@NC-300 needs only a voltage of 1.53 V to achieve the current density of 10 mA cm−2. Moreover, the flexible Zn-air battery assembled with CoN@NC exhibits high performance and superior durability. This work offers a novel method for designing metal nitride hybrids as highly efficient multifunctional electrocatalysts towards electrocatalysis and energy storage. [ABSTRACT FROM AUTHOR]

The conversion mechanism of 2D FePS 3 material offers superior electrochemical performance. The introduction of the N-doped carbon layer can facilitate the buffering of volume expansion and serve as efficient Na+/electron transfer pathways to promote the charging-discharging process of inner FePS 3 nanosheets. [Display omitted] • FePS 3 /NC is designed as a potential anode material for sodium-ion batteries. • 2D structure of layered MPS 3 provides enough active sites. • N-doped carbon ensures fast charge transfer and structural stabilization. • The reaction mechanism is investigated by ex-situ XRD and DFT calculations. The development of anode materials with high-rate capability and long cyclability has become a research hotspot for sodium-ion batteries (SIBs). In this work, we propose a simple and convenient method for the synthesis of few-layered FePS 3 nanosheets modified by N-doped carbon (FePS 3 @NC) through a controllable coating of polydopamine on the surface of exfoliated FePS 3 nanosheets followed by subsequent carbonization. The optimized FePS 3 @NC anode exhibits a superior capacity performance for 800 cycles with a high specific capacity of 281 mAh g−1 at 1.0 A g−1 due to high ionic conductivity of metal phosphorus trichalcogenides (MPS 3) and the unique two-dimensional (2D) few-layered structure of ultrathin nanosheets. Besides, the N-doped carbon layer (NC) decreases Na+ diffusion resistance and buffers the volumetric change during cycles, which are validated by the ex-situ X-ray diffraction and density functional theory (DFT) calculations. Furthermore, the full cell coupled by FePS 3 @NC anode and Na 3 V 2 (PO 4) 3 /carbon (NVP/C) cathode also displays high cycling stability. This work gives insight into the development of superior properties anodes for SIBs based on two-dimensional (2D) van der Waals crystals. [ABSTRACT FROM AUTHOR]

[Display omitted] This review summarizes recent progresses on glutathione (GSH)-mediated nanomedicines for cancer diagnosis and therapy. The specific feature of GSH in tumor cells and normal cells is discussed. GSH-responsive drug delivery systems, GSH mediated dynamic therapy, immunotherapy and GSH triggered cancer imaging and theranostics are elaborated. As one of the most important intracellular antioxidants and redox balance regulators, glutathione (GSH) plays a vital role in cell growth and proliferation, drug detoxification and free radical scavenging. In cancer cells, GSH concentration is several folds higher than that in normal cells. In this decade, with the rapid development of nanotechnology and nanomedicine, many studies have developed GSH as an efficient target or trigger for cancer diagnosis and therapy. Nevertheless, reviews systematically summarizing GSH related nanomedicines are still rare. In this review, the different characteristics and functions of GSH in normal and cancer cells are firstly analyzed. Then, recent progresses on GSH-mediated nanomedicines for cancer diagnosis and therapy are comprehensively summarized, including GSH-responsive drug delivery systems, GSH mediated dynamic therapy, immunotherapy and GSH-triggered cancer imaging and theranostics. Different strategies in these methods are discussed including direct utilization of GSH as a trigger and depletion of local GSH for the enhancement of therapy. Finally, the future perspectives and challenges in this field are proposed especially for clinical translation. It is expected that this review would provide some inspiration for future research and development for GSH-mediated nanomedicines. [ABSTRACT FROM AUTHOR]

The as-prepared binder-free Co 1−x S/MCF anode exhibits the desirable electrochemical performance for LIBs and SIBs, which can be attributed to the unique hierarchical nanostructure which provides enough active sites and internal space for volume expansion. [Display omitted] • The flexible Co 1−x S/MCF electrode is prepared via the electrospinning technique. • The Co 1−x S/MCF presents hierarchically hollow and multichannel structures. • The Co 1−x S/MCF electrode can effectively ease the huge volume expansion. • The Co 1−x S/MCF electrode shows high electrochemical performance for LIBs and SIBs. The exploration of prospective electrode materials represents great challenges for remarkable lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs). Herein, we report a reliable synthetic approach for the in-situ growth of the Co-based zeolitic imidazolate framework (ZIF-67) on electrospun nanofibers, followed by carbonization and sulfurization with the formation of free-standing Co 1−x S hollow polyhedrons anchored on multichannel carbon nanofibers (Co 1−x S/MCF) for LIBs and SIBs. The Co 1−x S/MCF electrode displays a high reversible capacity (813 mAh g−1 over 180 cycles at 0.1 A g−1), and stable cycle performance (559 mAh g−1 for 300 cycles at 1 A g−1) in LIBs. For SIBs, Co 1−x S/MCF electrode exhibits a favorable Na-storage capacity (433 mAh g−1 over 120 cycles at 0.1 A g−1). The as-prepared binder-free Co 1−x S/MCF anode demonstrates the advanced electrochemical properties for LIBs and SIBs. It is attributed to the particular multichannel nanostructure and the Co 1−x S hollow polyhedrons (Co 1−x S HPs), which provide enough active sites, and the internal void space effectively reduces the structural strain and eases the volume expansion to maintain structural integrity. This work gives insights to design a unique structure for promising LIBs and SIBs. [ABSTRACT FROM AUTHOR]

The as-prepared binder-free Co 1−x S/MCF anode exhibits the desirable electrochemical performance for LIBs and SIBs, which can be attributed to the unique hierarchical nanostructure which provides enough active sites and internal space for volume expansion. [Display omitted] • The flexible Co 1−x S/MCF electrode is prepared via the electrospinning technique. • The Co 1−x S/MCF presents hierarchically hollow and multichannel structures. • The Co 1−x S/MCF electrode can effectively ease the huge volume expansion. • The Co 1−x S/MCF electrode shows high electrochemical performance for LIBs and SIBs. The exploration of prospective electrode materials represents great challenges for remarkable lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs). Herein, we report a reliable synthetic approach for the in-situ growth of the Co-based zeolitic imidazolate framework (ZIF-67) on electrospun nanofibers, followed by carbonization and sulfurization with the formation of free-standing Co 1−x S hollow polyhedrons anchored on multichannel carbon nanofibers (Co 1−x S/MCF) for LIBs and SIBs. The Co 1−x S/MCF electrode displays a high reversible capacity (813 mAh g−1 over 180 cycles at 0.1 A g−1), and stable cycle performance (559 mAh g−1 for 300 cycles at 1 A g−1) in LIBs. For SIBs, Co 1−x S/MCF electrode exhibits a favorable Na-storage capacity (433 mAh g−1 over 120 cycles at 0.1 A g−1). The as-prepared binder-free Co 1−x S/MCF anode demonstrates the advanced electrochemical properties for LIBs and SIBs. It is attributed to the particular multichannel nanostructure and the Co 1−x S hollow polyhedrons (Co 1−x S HPs), which provide enough active sites, and the internal void space effectively reduces the structural strain and eases the volume expansion to maintain structural integrity. This work gives insights to design a unique structure for promising LIBs and SIBs. [ABSTRACT FROM AUTHOR]

Benefiting from the structure and electronic engineering, the self-supported N doped NiSe 2 hierarchically nanoflake arrays grown on flexible carbon cloth present superior performance with high stability and robust flexibility for solid-state zinc-air batteries. • The self-supported cathode electrode can satisfy the flexibility for solid-state zinc-air batteries. • Nitrogen doping can optimize the electronic structure and absorption feature of NiSe 2. • The open and porous structure provides more active sites and facilitates the mass transfer process. • N-NiSe 2 /CC exhibits outstanding performance for oxygen evolution/reduction reaction and zinc-air batteries. Rational design of efficient bifunctional air cathodes towards oxygen evolution/reduction reaction is of central importance for energy-efficient metal-air batteries, but remains an ongoing challenge. Here, N element doped NiSe 2 nanosheets in-situ grown on the carbon cloth were prepared via facial hydrothermal synthesis of nickel hydroxide followed by selenization and nitrogen doping treatment. Such self-supported N-doped NiSe 2 nanoarrays (N-NiSe 2 /CC) exhibits superior bifunctional catalytic activity and high durability compared with the pristine NiSe 2 /CC, which are ascribed to the unique structure after nitrogen doping. Nitrogen doping can provide more electrocatalytical active sites and improve the electronic transport for fast reaction kinetics, which is preferably corroborated with density functional theory calculations and X-ray absorption spectroscopy. As a proof of concept, the solid-state zinc-air batteries assembled by the N-NiSe 2 /CC directly as the air cathode present a low overpotential of 0.75 V, remarkable cyclic stability of 30 h with 90 circles, and robust flexibility. Therefore, the N-NiSe 2 /CC system proves to be a highly active and reliable electrode for the developing of metal-air batteries, opening up a promising opportunity for high-performance portable electronics. [ABSTRACT FROM AUTHOR]