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[Display omitted] • The effect of Coriolis force and herringbone grooves on mixing performance in rotating microchannels was investigated. • The Coriolis force balanced appropriately with centrifugal force achieved efficient mixing. • Two strategies of the Coriolis force and herringbone induced multiple local vortices, improving mixing efficiency. • A two-sided herringbone mixer required the shortest channel length for 90% mixing in this study. Mixing is a critical process in reagent reactions used in biomedical applications. Nevertheless, achieving rapid mixing in microfluidics is challenging because of the low-Reynolds region. This study numerically investigated the mixing performance of a rotating channel based on the Coriolis force with herringbone grooves. In the absence of grooves, the mixing was maximized when the Coriolis force was appropriately balanced with the centrifugal force. As the aspect ratio increased from 0.5 to 2.0, rapid mixing was achieved owing to the decreased transverse distance between the rotating flows. Mixing improved with the herringbone grooves, achieving up to >90% for the shortest channel length (20 mm) among the various microchannels. This enhancement resulted from the flow split and recombination induced by the combination of the Coriolis force and grooves. This study will help create and design microchannels for disk chip miniaturization, automation, and integration into lab-on-a-disk-based biomedical procedures, such as point-of-care diagnosis. [ABSTRACT FROM AUTHOR]