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Your search keyword '"Dmytro M. Khomenko"' showing total 2 results
Start Over Author "Dmytro M. Khomenko" Journal chemical papers
2 results on '"Dmytro M. Khomenko"'

1. Cis-Palladium(II) complex incorporating 3-(2-pyridyl)-5-methyl-1,2,4-triazole: structure and cytotoxic activity

Author

Borys V. Zakharchenko, Ilona V. Raspertova, Anna Grebinyk, Dmytro M. Khomenko, M.S. Slobodyanik, Sergiu Shova, Marcus Frohme, Svitlana Prylutska, Roman O. Doroschuk, O. P. Matyshevska, I. I. Grynyuk, and Rostislav D. Lampeka

Subjects
Stereochemistry, General Chemical Engineering, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biochemistry, Industrial and Manufacturing Engineering, HeLa, Materials Chemistry, medicine, Cytotoxic T cell, Cytotoxicity, Cisplatin, biology, Chemistry, Ligand, Lymphoblast, General Chemistry, Nuclear magnetic resonance spectroscopy, 021001 nanoscience & nanotechnology, biology.organism_classification, 0104 chemical sciences, 0210 nano-technology, medicine.drug, Palladium
Abstract

The structure of complex cis-Pd(HLMe)Cl2 was studied both in solution and in solid state using multinuclear (1H, 13C, 15N) NMR spectroscopy and X-ray structural analysis. Complex was evaluated for cytotoxic activity. Thus, the results showed that cis-Pd(HLMe)Cl2 has a pronounced cytotoxicity toward human leukemic lymphoblast’s CCRF-CEM and cervix adenocarcinoma HeLa cells. Moreover, it was found that cis-Pd(HLMe)Cl2 is more toxic than cisplatin: its IC50 value at 24 h incubation was lower by more than an order for CCRF-CEM cells and by three orders for HeLa cells as compared with cisplatin IC50. Depending on the concentration, cis-Pd(HLMe)Cl2 is accelerated or slowed hemolysis of erythrocytes. Observed differential biological effects of cis-Pd(HLMe)Cl2 suggest the dependence of the agent’s interactions with cells on the molecular structure of palladium ligand and the cell type.

Published
2021

2. Influence of the nature of the substituent in 3-(2-pyridyl)-1,2,4-triazole for complexation with Pd2+

Author

Borys V. Zakharchenko, Olga V. Severynovska, Victoria S. Starova, Roman O. Doroshchuk, Ilona V. Raspertova, Rostyslav D. Lampeka, and Dmytro M. Khomenko

Subjects
010405 organic chemistry, Stereochemistry, General Chemical Engineering, Substituent, chemistry.chemical_element, 1,2,4-Triazole, General Chemistry, 010402 general chemistry, Mass spectrometry, 01 natural sciences, Biochemistry, Medicinal chemistry, Fluorescence, Industrial and Manufacturing Engineering, 0104 chemical sciences, chemistry.chemical_compound, Fluorescence intensity, Ultraviolet visible spectroscopy, chemistry, Materials Chemistry, Palladium
Abstract

The structure of four new palladium complexes [Pd(HL 2 )Cl 2 and Pd(L 1–3 ) 2 ] with 3-(2-pyridyl)-5-R-1,2,4-triazoles (R=H, CH3, Ph respectively HL 1 , HL 2 , HL 3 ) was proposed based on IR, NMR, UV spectroscopy and MALDI mass spectrometry data analysis. It is found that the complexation of HL 2 and HL 3 with Pd2+ ions results in a decrease of their fluorescence intensity and it is vice versa in case of HL 1 . Furthermore, the influence of the substituent (R) in the 3-(2-pirydyl)-5-R-1,2,4-triazoles on the fluorescent and protolytic properties of HL 1–3 was investigated.

Published
2017

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