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Your search keyword '"Sulfanilamides blood"' showing total 4 results
Start Over Descriptor "Sulfanilamides blood" Journal chemical pharmaceutical bulletin
4 results on '"Sulfanilamides blood"'

1. Binding of 2-amino-4-chloro-m-benzenedisulfonamide as a metabolite of hydrochlorothiazide to erythrocytes.

Author

Yamazaki M, Itoh S, Saji J, Tanabe K, Nakahama H, and Orita Y

Subjects
Animals, Erythrocytes drug effects, Erythrocytes metabolism, In Vitro Techniques, Rabbits, Sulfanilamides pharmacokinetics, Hydrochlorothiazide blood, Sulfanilamides blood
Abstract

2-Amino-4-chloro-m-benzenedisulfonamide (ACBS) is a metabolite of hydrochlorothiazide. We reported that the ACBS concentration in erythrocytes was higher than in plasma in a patient. Therefore the binding of ACBS to rabbit erythrocyte was studied. The Scatchard plot showed the nonlinear plot and the horizontal asymptote. Curvature in this plot indicated the existence of 2 classes of binding. One class was at a specific site, probably at carbonic anhydrase. Chromatographic data seemed to support the possibility.

Published
1990
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3. Studies on the mechanism of drug allergy to sulfanilamides. I. A colorimetric method for the determination of 4-hydroxylaminobenzenesulfonamide in biological materials with sodium pentacyanoammineferroate.

Author

Yamamoto I, Eyanagi R, Yoshida K, and Yamamoto A

Subjects
Animals, Colorimetry, Drug Hypersensitivity, Humans, Hydroxylamines, Quaternary Ammonium Compounds, Rats, Sulfanilamides blood, Sulfanilamides urine, Iron, Organometallic Compounds, Sulfanilamides adverse effects
Published
1973
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