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Your search keyword '"Xu, WenQin"' showing total 2 results
Start Over Author "Xu, WenQin" Journal chemical research in chinese universities
2 results on '"Xu, WenQin"'

2. Synthesis, biological activity and 3D-QSAR study of novel pyrrolidine-2,4-dione derivatives containing N-substituted phenylhydrazine moiety

Author

Ren Zhengjiao, Chunlong Yang, Ding Weijie, Bao Qianqian, Aimin Lu, Zhang Lizhi, Xu Wenqin, and Zhao Zheng

Subjects
chemistry.chemical_compound, Quantitative structure–activity relationship, chemistry, Stereochemistry, Proton NMR, Moiety, Biological activity, General Chemistry, Carbon-13 NMR, Phenylhydrazine, Pyrrolidine, EC50
Abstract

Twenty-seven novel pyrrolidine-2,4-dione derivatives containing N-substituted phenylhydrazine moiety were synthesized. Their structures were confirmed by 1H NMR, 13C NMR and MS. The half effective concentration (EC50) values of the title compounds against the phytopathogenic fungi Rhizoctonia cerealis were evaluated. Compounds 6l and 6q displayed good bioactivity with EC50 values of 1.626 and 2.043 μg/mL, respectively. The 3D quantitative structure activity relationship(3D-QSAR) model of CoMFA was established with reliable cross-validated correlation coefficient q 2 value of 0.585 and Noncross-validated correlation coefficient r 2 value of 0.971. This model provided a tool for guiding further design and synthesis of novel pyrrolidine-2,4-dione derivatives with high fungicidal activity.

Published
2015

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