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Start Over Author "Hiroki Terauchi" Journal chemical science
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1. Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites

Author

Kiyosei Takasu, Akira Naganuma, Hiroki Terauchi, Hidetoshi Tokuyama, Hiroshi Inoue, Yusuke Wataya, Daiki Morisaki, Hye Sook Kim, Shusuke Kuge, and Masataka Ihara

Subjects
chemistry.chemical_compound, Rhodacyanine, chemistry, In vivo, medicine, General Chemistry, Biology, Mitochondrion, Growth inhibition, medicine.disease, In vitro, Malaria, Cell biology
Abstract

Fluorescent rhodacyanines, which display antimalarial activity in vitro and in vivo, stain plasmodial parasites at the erythrocytic stage. A good correlation between the antimalarial activity and the accumulation of the dyes is observed. A fused-rhodacyanine, which displays a strong fluorescent property itself, was designed as a new probe for plasmodial parasites. It appears to be specifically localized in the parasitic mitochondria.

Published
2010
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