Search

Your search keyword '"Zhuofan Shen"' showing total 1 results
Start Over Author "Zhuofan Shen" Journal chemical science
1 results on '"Zhuofan Shen"'

1. Highly stereoselective and enantiodivergent synthesis of cyclopropylphosphonates with engineered carbene transferases

Author

Xinkun Ren, Ajay L. Chandgude, Daniela M. Carminati, Zhuofan Shen, Sagar D. Khare, and Rudi Fasan

Subjects
General Chemistry
Abstract

Organophosphonate compounds have represented a rich source of biologically active compounds, including enzyme inhibitors, antibiotics, and antimalarial agents. Here, we report the development of a highly stereoselective strategy for olefin cyclopropanation in the presence of a phosphonyl diazo reagent as carbene precursor. In combination with a 'substrate walking' protein engineering strategy, two sets of efficient and enantiodivergent myoglobin-based biocatalysts were developed for the synthesis of both (1

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results