1. Novel phenolic glycoside dimer and trimer from the whole herb of Pyrola rotundifolia
- Author
-
Taichi Inui and Jun Chang
- Subjects
Spectrometry, Mass, Electrospray Ionization ,Staphylococcus aureus ,Stereochemistry ,Polymers ,Dimer ,Trimer ,Microbial Sensitivity Tests ,medicine.disease_cause ,chemistry.chemical_compound ,Phenols ,Drug Discovery ,medicine ,Organic chemistry ,Glycosides ,Pyrola rotundifolia ,Pyrola ,chemistry.chemical_classification ,biology ,Chemistry ,Glycoside ,General Chemistry ,General Medicine ,biology.organism_classification ,Antimicrobial ,Micrococcus luteus ,Pyrolaceae ,Spectrophotometry, Ultraviolet ,Dimerization - Abstract
From the water-soluble constituents of the whole herb of Pyrola rotundifolia (Pyrolaceae), one novel phenolic glycoside dimer, pyrolaside A (1), and one novel phenolic glycoside trimer, pyrolaside B (2), together with two known phenolic glycosides homoarbutin (3) and isohomoarbutin (4), were isolated. The structures were elucidated by spectroscopic analysis and confirmed with chemical degradation. In vitro tests for antimicrobial activity showed pyrolaside B (2) to possess significant activity against two Gram-positive organisms, Staphylococcus aureus and Micrococcus luteus.
- Published
- 2005