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A broad range of o-bromostyrenes and o-chlorostyrenes undergo tandem annulations with NaSH to afford benzothiophenes.

The Pd-memantine complex (PCM) efficiently catalyzes the coupling of a wide range of aryl bromides with arylboronic acids at 80°C or at room temperature.

The annulation reaction involves the direct α-alkenylation of ketones (II) and a subsequent intramolecular O-arylation process affording title compounds (III) in moderate to good yields.

The method allows access to a broad spectrum of indene structures bearing an exocyclic alkylidene part.

Lanthanoid-doped Na3Zr(Hf)F7 nanocrystals are prepared solvothermally from EtOH solutions containing MOCl2 (M: Zr, Hf), Ln(NO3)3 (Ln: La—Lu), NH4F, sodium oleate, oleic acid, oleylamine, and H2O (autoclave, 130 °C, 12 h).

The title nanocrystals are solvothermally synthesized from mixtures of Ln(NO3)3 (Ln: La—Lu, Y), Ba(NO3)2, NH4F, NaOH, EtOH, oleic acid, and H2O (autoclave, 180 °C, 24 h).

A regio- and stereoselective synthesis of the title compounds is achieved by Cu(I)-catalyzed tandem thiolation and 6-exo-dig heterocyclization with NaHS.

A palladium- and copper-catalyzed tandem N–H/C–H bond functionalization reaction of ortho-(2-chlorovinyl)bromobenzenes with indoles and pyrroles has been developed. A variety of CF3-containing indolo- and pyrrolo[2,1-a]isoquinolines were prepared in moderate to good yields via the cyclization of 1-bromo-2-(2-chloro-3,3,3-trifluoroprop-1-enyl)benzenes with indoles and pyrroles.

The commercially available diphosphane ligand MeO-BIPHEP was first investigated in the palladium-catalyzed Sonogashira reaction in the absence of copper and amine. The coupling of various aryl bromides and aryl chlorides with phenylacetylene gave moderate to excellent yields.

A copper-catalyzed thiolation annulation reaction of 2-bromo alkynylbenzenes with sodium sulfide has been developed. In the presence of CuI and TMEDA, a variety of 2-substituted benzo[b]thiophenes were readily prepared in moderate to good yields by the reaction of 2-bromo alkynylbenzenes and Na2S·9H2O.

Ligularia, an important genus of the Compositae family, has captured the interest of natural product chemists for years. Phytochemical investigations on the title genus have led to isolation of hundreds of secondary metabolites with various skeletons. Herein, we summarized the chemical constituents of this genus and their biological activities over the past few decades. Open image in new window

A highly active catalyst system derived from PdCl2 and2,2′,6,6′-tetramethoxy-4,4′-bis(diphenylphosphanyl)-3,3′-bipyridine (P-Phos) has been developed for the Suzuki cross-coupling reaction of pyridylboronic acid with a variety of aryl halides in good to excellent yields, even in the presence of hindered and functional groups. In addition, P-Phos also exhibited high activity in the palladium-catalyzed Suzuki reaction of 2,6-dimethoxypyridylboronic acid in excellent yields with a fast rate. The steric and electronic effects of the P-Phos–palladium complex to this cross-coupling reaction were also discussed.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)