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5 results on '"A. M. Demin"'

2. ChemInform Abstract: Total Synthesis of 20-Hydroxy-hepoxilins, New Metabolites of the Hepoxilin Family

Author

T. A. Manukina, Peter M. Demin, Cecil R. Pace-Asciak, and Kasimir K. Pivnitsky

Subjects
chemistry.chemical_compound, chemistry, Stereochemistry, Metabolite, Hepoxilin, Total synthesis, General Medicine, Hepoxilin B, Hepoxilin A
Abstract

A newly described enzymatically formed ω-hydroxy metabolite of hepoxilin A 3 (HxA 3 ) has been prepared via total synthesis involving polyacetylenic intermediates and Mitsunobu rearrangement of the intermediate putative ω-hydroxy metabolite of hepoxilin B 3 .

Published
2010

3. ChemInform Abstract: New Synthesis of Estradiol from Androsta-1,4-diene-3,17-dione

Author

Margarita A. Lapitskaya, K. K. Pivnitsky, D. M. Kochev, Ljudmila L. Vasiljeva, and P. M. Demin

Subjects
chemistry.chemical_compound, Diene, chemistry, Yield (chemistry), Aromatization, Side chain, General Medicine, Ring (chemistry), Medicinal chemistry
Abstract

A new method for the aromatization of ring A in androsta-1,4-diene-3,17-dione, available from sterols by means of the microbiological degradation of the side chain, was developed. The method consists of the reduction of androsta-1,4-diene-3,17-dione to the corresponding dienediol followed by double C,O-deprotonation of ring A, accompanied by expulsion of the 19-methyl group and formation of estradiol in a high yield.

Published
2010

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