Search

2-Allylaminodihydrothiazole derivatives (III) are synthesized by condensation of allylthiourea (I) with haloesters (II) in alkaline medium, whereas 2-allylaminothiazole derivatives (V) are obtained by condensation of (I) with chlorooxoesters (IV) via acetal as intermediate compound, both of them with good yields.

In this research, conditions of cyclization of dimethyl 2-[(1-arylamino-1-arylme-thylidene)hydrazono]succinate 1 – 5 leading to the formation of 3,4-diaryl-5-carboxymethyl-1,2,4-triazole 6 – 10 and methyl 2-(5-oxo-3,4-diaryl-1,4,5,6-tetrahydro-1,2,4-triazine-6-ylidene)acetates 11 – 15 and the biological activity of some of them have been examined. Their chemical structures were confirmed by IR, 1 H-NMR, EI-MS and elemental analysis. Substances 8 and 13 exhibited moderate virucidal activity and partially inhibited absorption of the viruses to the susceptible cells. The acute toxicity of compounds 6–10 was established. For compounds 8 and 13 , the influence on the central nervous system of mice and rats in behavioral tests was examined.