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158 results on '"Duan, Zheng"'

1. ChemInform Abstract: Synthesis of Several New 1-Arylpyrazolo[3,4-d]pyrimidines Containing an Amide Moiety

Author

Xin-wei Zhang, Duan-Zheng Song, Ju Liu, Zhou Yunpeng, and Cai Zhiqiang

Subjects
chemistry.chemical_compound, Ammonium hydroxide, chemistry, Pyrimidine, Amide, Condensation, Polymer chemistry, Molecule, Moiety, General Medicine, Triethyl orthoformate, Tetrahydrofuran
Abstract

A series of novel 1-arylpyrazolo[3,4-d]pyrimidine derivatives, containing an amide moiety, was synthesised by condensation of different acids with 1-(2,4-dichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. This intermediate was prepared from 5-amino-1-(2,4-dichlorophenyl)-1H-pyrazole-4-carbonitrile by condensation with triethyl orthoformate and then cyclisation with ammonium hydroxide solution in tetrahydrofuran at room temperature. In addition, the molecular structure of a 1-arylpyrazolo[3,4-d]pyrimidine containing an amide moiety was determined by single crystal X-ray diffraction.

Published
2016

7. Reaction of Zirconacyclopentadienes with Electrophiles such as Benzaldehyde, Methyl Methacrylate and 1-Bromo-2-butyne After Treatment with RLi

Author

Takashi Seki, Wen-Hua Sun, Tamotsu Takahashi, Duan Zheng, and Yoshinori Noguchi

Subjects
chemistry.chemical_classification, Addition reaction, Nucleophilic addition, Organic Chemistry, Propargyl chloride, General Medicine, Biochemistry, Medicinal chemistry, Aldehyde, Benzaldehyde, chemistry.chemical_compound, chemistry, Drug Discovery, Electrophile, Butyllithium, Michael reaction, Organic chemistry, Methyllithium
Abstract

Zirconacyclopentadienes reacted with electrophiles after treatment with alkyllithium. For example, the reaction with benzaldehyde after treatment with methyllithium to give a nucleophilic addition product of a dienyl moiety to aldehyde, dienylcarbinol, in a moderate yield. Similar reaction of a zirconacyclopentadiene using butyllithium with methyl methacrylate afforded a Michael addition product in a good yield. Treatment of zirconacyclopentadienes with n-BuLi followed by 1-bromo-2-butyne gave a mono-propargylated diene derivative in 95% yield after hydrolysis. When propargyl chloride was treated with n-BuLi first and then added to zirconacyclopentadienes, penta-substituted benzene derivatives were formed in high yields.

Published
2005

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