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3 results on '"J Lyman"'

1. ChemInform Abstract: Regioselective ortho Alkylation of Nitro Indole, Carbazole, Benzothiophene and Benzofuran

Author

J. Lyman Feron, Scott G. Lamont, Sam D. Groombridge, and Craig S. Donald

Subjects
Indole test, chemistry.chemical_classification, chemistry.chemical_compound, chemistry, Carbazole, Nitro, Benzothiophene, Regioselectivity, General Medicine, Benzofuran, Alkylation, Medicinal chemistry, Alkyl
Abstract

Substituted indoles, carbazoles, benzothiophenes and benzofurans are important motifs in the pharmaceutical industry. Herein we report a novel, regioselective method to introduce alkyl substituents into position ortho of nitro groups by the addition of a Grignard reagent followed by subsequent oxidation with DDQ.

Published
2016
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2. ChemInform Abstract: Synthesis of Functionalized Cyanopyrazoles via Magnesium Bases

Author

Andrew D. Roberts, Iain Simpson, Matthew R. Tatton, Allan Dishington, Ian A. Hollingsworth, J. Lyman Feron, Jennifer H. Pink, Kathryn Gill, and Mark A. Graham

Subjects
chemistry, Magnesium, Electrophile, chemistry.chemical_element, General Medicine, Combinatorial chemistry
Abstract

4-Alkyl- and 4-H-pyrazoles were sequentially metalated using TMPMgCl·LiCl, and their reaction with electrophiles afforded 3-aryl-4-alkyl-5-cyanopyrazoles.

Published
2015
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