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Your search keyword '"J. C. Wilker"' showing total 3 results
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3 results on '"J. C. Wilker"'

1. ChemInform Abstract: Synthesis and Structure-Activity Relationships of N-Propyl-N-(4- pyridyl)-1H-indol-1-amine (Besipirdine) and Related Analogues as Potential Therapeutic Agents for Alzheimer′s Disease

Author

J. C. Wilker, G. S. Wong, E. Landau, R. D. Blitzer, Richard C. Effland, Lawrence L. Martin, Vahram Haroutunian, Larry Davis, Craig P. Smith, Francis P. Huger, Klein Joseph Thomas, Olsen Gordon Edward, Wayne W. Petko, and Michael Cornfeldt

Subjects
Chemistry, Stereochemistry, medicine, Purine derivative, Amine gas treating, General Medicine, Besipirdine, Combinatorial chemistry, medicine.drug
Published
2010

3. ChemInform Abstract: Synthesis of 5-Phenylpyrrolo(1,2-b)(1,2,5)triazepin-2(3H)-ones

Author

R. Richard L. Hamer, Richard C. Effland, Klein Joseph Thomas, Francis P. Huger, and J. C. Wilker

Subjects
Hydrolysis, Chemistry, Organic chemistry, General Medicine, Anxiolytic agents
Abstract

The synthesis of a series of 5-phenylpyrrolo[1,2-b][1,2,5]triazepin-2(3H)-ones 1 as potential anxiolytic agents is described. Benzoylation of 1-phthalimidopyrrole, followed by hydrolysis, gave the 1-amino-2-benzoylpyrroles 3. These were further functionalized to give the penultimate 1-aminoacetamido-2-benzoylpyrroles 8 and 9, which were cyclized to the target pyrrolotriazepines 1.

Published
1988

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