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Your search keyword '"James Z. Deng"' showing total 2 results
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2 results on '"James Z. Deng"'

1. ChemInform Abstract: Expanding the Scope of the Cu-Assisted Suzuki-Miyaura Reaction

Author

Christopher K. Prier, Brendan M. Crowley, Daniel V. Paone, James Z. Deng, Christopher S. Burgey, and Craig M. Potteiger

Subjects
Coupling, chemistry.chemical_compound, Scope (project management), Chemistry, Computational chemistry, Aryl, General Medicine, Stoichiometry
Abstract

The addition of stoichiometric amounts of CuCl efficiently improves the coupling of aryl chlorides and of polyhalo or hindered arylboronates to give higher yields in a shorter time.

Published
2011
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2. ChemInform Abstract: Copper-Facilitated Suzuki Reactions: Application to 2-Heterocyclic Boronates

Author

Steven A. Weissman, Daniel V. Paone, Christopher S. Burgey, Hideki Kurihara, Anthony Ginnetti, Shaun R. Stauffer, James Z. Deng, and Spencer D. Dreher

Subjects
Suzuki reaction, Scope (project management), Catalytic cycle, Chemistry, chemistry.chemical_element, General Medicine, Bond formation, Combinatorial chemistry, Copper
Abstract

The palladium-catalyzed Suzuki-Miyaura reaction has been utilized as one of the most powerful methods for C-C bond formation. However, Suzuki reactions of electron-deficient 2-heterocyclic boronates generally give low conversions and remain challenging. The successful copper(I) facilitated Suzuki coupling of 2-heterocyclic boronates that is broad in scope is reported. Use of this methodology affords greatly enhanced yields of these notoriously difficult couplings. Furthermore, mechanistic investigations suggest a possible role of copper in the catalytic cycle.

Published
2009
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