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1. ChemInform Abstract: Synthesis of 4-Aza-cholestane Derivatives Containing Nitrosoureido Function as Antitumor Activity

Author

Jin Il Park, Tae-Ho Hur, and Jack C. Kim

Subjects
Antitumor activity, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, Stereochemistry, Cell, medicine, Cholestane, Nanotechnology, General Medicine, Function (biology), In vitro
Abstract

A series of 4-(2-chloroethyl)nitrosocarbamoyl- and 4-methyl nitrosocarbamoyl analogs of 4-Aza--cholestane (5a and 5b), 4-Aza-5-cholestene (6a and 6b) were synthesized and evaluated for their inhibitory activity against the Sarcoma 180 cell. The steroidal nitrosoureas, 5a, 5b, 6a and 6b displayed modest activity in vitro.

Published
2010
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