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A first report to demonstrate the utility of (trifluoromethyl)trimethylsilane as an efficient reagent for the synthesis of perfluorinated porphyrins, chlorins and bacteriochlorins is presented.

This study presents a novel approach for the regioselective synthesis of a series of alkyl ether analogues of purpurin-18-N-alkylimide. In the purpurinimide series, this is the first example which demonstrates that the presence and position of the substituents in the macrocycle makes a remarkable difference in the in vivo PDT efficacy.