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Synthesis of structurally novel aza-and oxa-polyquinanes from the abundantly available cis,syn,cis-triquinane dione 1 via transannular nucleo-phillc additions is reported.

Chiral intermediates [(−)-8, (+)-9, (−)-9, (+)-10, (−)-10, (+)-11] useful in the synthesis of drimanes and labdanes, as well as optically active albicanol 1 and albicanyl acetate 2, have been synthesized using enzymatic transesterification as the key step.

The synthesis of novel polycyclic amides has been achieved through the reaction of bishalomethyl pentacyclo[5.4.0.02,6.03,10.05,9]undecane diones with acyclic and cyclic secondary amines in the presence of an ionic liquid. Three of the compounds prepared have been found to possess antituberculosis activity.

Phytochemical investigations on the leaves of Dysoxylum malabaricum and Dysoxylum beddomei result in the isolation of a number of triterpenes. Acetylation and deacetylation studies on some of the representative triterpenes show appreciable rate enhancement and increase of yield in the presence of microwave radiation. Details of isolation of triterpenes, acetylation and deacetylation procedures and their results form the subject of the paper. Triterpenes of three skeletal types namely lupane, tirucallane and cycloartane are examined. All the triterpenes examined indicate an increase of cytotoxicity with acetylation.

Enzymatic kinetic resolution of racemic aryl β - hydroxy ketones in organic media catalyzed by Candida cylindracea lipase is reported.