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2 results on '"Pamela Austin"'

1. Avinosol, a Meroterpenoid-Nucleoside Conjugate with Antiinvasion Activity Isolated from the Marine Sponge Dysidea sp

Author

Pamela Austin, Michel Roberge, Rob W. M. Van Soest, Teatulohi Matainaho, Calvin D. Roskelley, Raymond J. Andersen, and Ana R. Díaz-Marrero

Subjects
Terpene, Sponge, biology, Chemistry, Stereochemistry, Nucleic acid, New guinea, General Medicine, biology.organism_classification, Nucleoside, Conjugate
Abstract

The new meroterpenoids avinosol (1), 3‘-aminoavarone (2), and 3‘-phenethylaminoavarone (3) have been isolated from the marine sponge Dysidea sp. collected in Papua New Guinea, and their structures were elucidated by analysis of spectroscopic data. Avinosol (1), which is apparently the first example of a naturally occurring meroterpenoid-nucleoside conjugate, showed antiinvasion activity in a cell-based assay.

Published
2007

2. Neopetrosiamides, Peptides from the Marine Sponge Neopetrosia sp. that Inhibit Amoeboid Invasion by Human Tumor Cells

Author

Raymond J. Andersen, Calvin D. Roskelley, Teatulohi Matainaho, Michel Roberge, Ana R. Díaz-Marrero, David E. Williams, Rob Van Soest, and Pamela Austin

Subjects
Human tumor, Sponge, food.ingredient, food, biology, Chemistry, Stereochemistry, Diastereomer, New guinea, General Medicine, biology.organism_classification, Neopetrosia, Nmr data
Abstract

[structure: see text] Neopetrosiamdes A (1) and B (2), two diastereomeric tricyclic peptides that inhibit amoeboid invasion of human tumor cells, have been isolated from the marine sponge Neopetrosia sp. collected in Papua New Guinea. The structures of the neopetrosiamides were elucidated by analysis of MS and NMR data and confirmed by chemical degradation.

Published
2006

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