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Compound (IIIe) is found to exhibit high antiproliferative activity against B16-F10, HeLa, and MCF-7 in vitro.

Some of the synthesized compounds exhibit single digit micromolecular inhibition of ALK in vitro.

Acenaphthenone (ANO) is an effective electron donor and undergoes stepwise photooxygenation sensitized by 9,10-dicyanoanthracene, affording hydroxylactone and anhydride derivatives; the electron transfer mechanism via an enol intermediacy was verified by the enhancement effect of biphenyl, fluorescence quenching, exciplex emission and chemically induced dynamic nuclear polarization (CIDNP).

Syntheses of the four enantiomerically pure diastereomers of 8-F2t-isoprostane (5−8) are described. The key to this approach was to prepare the racemic alcohol 9 in high diastereomeric purity and t...

The tricycle 18 containing the oxygenated ring C is constructed from ( S )-carvone in 14 steps involving a Shapiro reaction and a selective acylation as the key steps.

The first total synthesis of (-)-calicoferol B (III) is described. The cyclozirconation product I, prepared in enantiomerically pure form, was converted into the CD ring chiron II. This was coupled with the aromatic A-ring, and then the side chain was constructed with control of relative and absolute configuration to complete the total synthesis of III. The first total synthesis of (-)-calicoferol B (1) is described. The cyclozirconation product 8, prepared in enantiomerically pure form, was converted into the CD ring chiron 6. This was coupled with the aromatic A-ring, and then the side chain was constructed with control of relative and absolute configuration to complete the total synthesis of 1.

Two analogues of cryptophycin were synthesized and biologically evaluated for their in-vitro cytotoxicities against several solid tumors and leukemia cell lines. The results revealed that both analogues exhibited a broad range of cytotoxic activity with observed IC(50 )values in the muM-range, and compound 4 was more effective than compound 3 in most assays studied.

A new benzylisoquinoline alkaloid, named nelumstemine ( 1 ), 1-(4′-hydroxybenzoyl)-6,7-dimethoxy-3,4-dihydroisoquinoline, was isolated from the stems of Nelumbo nucifera Geartn . Its structure was established on the basis of spectral analysis.

Isopropoxide protection of arylboronates allowed their use in metal-halogen exchange reactions. The isopropoxide-protected borate species were obtained from a boronate or in situ from dibromoarenes. meta- and para-dibromoarenes were converted via these intermediates into functionalized arylboronates in a one-pot manner.

From the ethanol extract of the stems of Aristolochia manshuriensis, two new alkaloids, namely manshurienine A (1) and manshurienine B (2), were isolated together with six known compounds, i.e., aristoloside (3), aristolochic acid I (4), aristolochic acid II (5), aristolic acid II (6), aristolochic acid IVa (7), and aristolochic acid IIIa (8). The structures of 1 and 2 were elucidated on the basis of spectroscopic methods, mainly by using 1H-and 13C-NMR spectroscopy, and the known compounds 3–8 were identified by comparing their physical and spectroscopic data with those of authentic data reported in the literature.

Green, mild and efficient electrophilic substitution reactions of indoles with various aldehydes were carried out using task-specific ionic liquids to afford the corresponding bis(indolyl)methanes in excellent yields.

A total synthesis of (+)-quassin from naturally occurring (S)-(+)-carvone is described. The total number of steps was 28, and the overall yield was about 2.6%. The synthetic strategy for the construction of the tetracyclic carbon framework was based on a C→ABC→ABCD ring annulation sequence, involving an aldol reaction, an intramolecular Diels−Alder reaction, and an intramolecular acylation as the key steps. Subsequent functionalization of ring A and ring C then afforded the target (+)-quassin.