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32 results on '"Sabharwal A"'

1. ChemInform Abstract: Synthesis of Polyhydroxylated Azetidine Iminosugars and 3-Hydroxy-N-methylazetidine-2-carboxylic Acid from D-Glucose

Author

Pravin P. Lawande, Roopa J. Nair, Sushma G. Sabharwal, Vaishali S. Shinde, Ayesha Khan, and Vyankat A. Sontakke

Subjects
chemistry.chemical_classification, biology, Stereochemistry, Carboxylic acid, Azetidine, Aspergillus niger, General Medicine, biology.organism_classification, chemistry.chemical_compound, Enzyme, chemistry, D-Glucose, Glycoside hydrolase, Hydroxymethyl, Mitsunobu reaction
Abstract

The azetidine iminosugars, (2S,3R)-2-((R)-1,2-dihydroxyethyl)azetidin-3-ol 3, (2R,3R)-2-(hydroxymethyl)azetidin-3-ol 4, and (2S,3R)-3-hydroxy-N-methylazetidine-2-carboxylic acid 5 were synthesized from d-glucose derived 3-N-benzyloxycarbonyl-3-deoxy-1,2-O-isopropylidene-α-d-xylofuranose 8 using intramolecular Mitsunobu reaction as a key step. The glycosidase inhibitory activity of compounds 3–5 was screened against various enzymes. Amongst all synthesized compounds, the N-methylated compound 5 exhibited significant inhibitory activity against amyloglucosidase from Aspergillus niger in micro molar range.

Published
2015
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7. ChemInform Abstract: Stereoselective Synthesis of (6Z,9Z)-6,9-Nonadecadiene and (6Z,9Z)-6,9-Heneicosadiene, Sex Pheromones of Bupalus piniarius and Utethesia ornatrix

Author

Sanjiv Sharma, V. Dogra, Madan L. Sharma, O. P. Vig, Mohammad A. Huq, A. Sabharwal, and Goverdhan L. Kad

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, Bupalus piniarius, Double bond, chemistry, Diene, Stereochemistry, Sex pheromone, Stereoselectivity, General Medicine, Gland secretion
Abstract

Electroantennogram active C19and C21-dienes, (6Z, 9Z)-6,9-nonadecadiene (I) and (6Z, 9Z)-6,9-heneicosadiene (II) have been isolated from the sex attractant gland secretion of female mohts Bupa/us piniarius and Utethesia ornatrix by Bestmann et aU and Meinwald et aI.2 •3 . The presence of two cis double bonds at C-6 and C-9 are the important structural features of these diene systems. Literature3 5 records syntheses of I and II leading to low yields. Herein, we report simple and stereoselective syntheses of I and II in good yields (see Scheme 1).

Published
1990
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