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124 results on '"Sener, A."'

2. ChemInform Abstract: Functionalization and Cyclization Reactions of 4-Benzoyl-1,5-diphenyl- 1H-pyrazole-3-carboxylic Acid

Author

Gert Kollenz, Alemdar Mustafa Ipekoglu, Y. Akcamur, and Ahmet Sener

Subjects
chemistry.chemical_classification, Carboxylic acid, Hydrazine, General Medicine, Pyrazole, Chloride, chemistry.chemical_compound, chemistry, Amide, medicine, Surface modification, Organic chemistry, Hydrate, Phenylhydrazine, medicine.drug
Abstract

The 1H-pyrazole-3-carboxylic acid 2 or its remarkably stable acid chloride 3 can easily be converted into the corresponding ester or amide derivatives 4 or 5, respectively, from reaction with alcohols or N-nucleophiles. Pyrazolo[3,4-d]pyridazines 6a,b are obtained from cyclocondensation reactions of the pyrazoles 2 and 3, respectively, with phenylhydrazine or hydrazine hydrate, while 6c is formed in an one-pot procedure from the furan-2,3-dione 1 and hydrazine hydrate.

Published
2010
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5. ChemInform Abstract: Alkaloids of Bongardia chrysogonum

Author

Gülnur Toker, K. Hüsnü Can Başer, Atta‐ur‐Rahman Atta‐ur‐Rahman, M. Iqbal Choudhary, Bilge Sener, and Durre Shahwar

Subjects
Bongardia, biology, Traditional medicine, Chemistry, General Medicine, biology.organism_classification, Chrysogonum
Published
2010
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6. ChemInform Abstract: Synthesis and Antimicrobial Activity of Some 2-[p-Substituted-phenyl]benzoxazol-5-yl-arylcarboxyamides

Author

Ismail Yalcin, Nurten Altanlar, Esin Aki-Sener, and Oezlem Temiz‐Arpaci

Subjects
Molar concentration, biology, Serial dilution, Chemistry, Proton NMR, General Medicine, biology.organism_classification, Spectral data, Antimicrobial, Bacteria, Yeast, Corpus albicans, Nuclear chemistry
Abstract

New 2-[p-substituted-phenyl ]benzoxazol-5-yl-arylcarboxyamides derivatives have been synthesized by reacting 5-amino-2-[p-substituted-phenyl ]benzoxazoles with substituted-arylcarboxylic acid chlorides. The structures of the synthesized compounds were confirmed by IR and (1)H NMR spectral data. Antimicrobial activities of the compounds were investigated using the two-fold serial dilution technique against different Gram-positive and Gram-negative bacteria and the yeast C. albicans in comparison with standard drugs. Microbiological results indicated that the synthesized compounds possess a broad spectrum of activity, having an MIC value of 25-200 microg/mL at molar concentration values of 3.45 x 10(-5) and 5.74 x 10(-4) against the tested microorganisms.

Published
2010
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10. Synthesis, Antimicrobial Activity and QSARs of New Benzoxazine-3-ones

Author

Ismail Yalcin, Esin Aki-Sener, Ilkay Yildiz, Betul Tekiner-Gulbas, Sabiha Alper-Hayta, Nurten Altanlar, and Oezlem Temiz‐Arpaci

Subjects
Quantitative structure–activity relationship, Antifungal Agents, Magnetic Resonance Spectroscopy, Spectrophotometry, Infrared, Serial dilution, Substituent, Quantitative Structure-Activity Relationship, Microbial Sensitivity Tests, Chemical synthesis, chemistry.chemical_compound, Candida krusei, Drug Discovery, Organic chemistry, Antibacterial agent, Pharmacology, biology, Organic Chemistry, General Medicine, biology.organism_classification, Antimicrobial, Combinatorial chemistry, Anti-Bacterial Agents, Benzoxazines, chemistry, Mic values, Proton NMR, Antibacterial activity, Bacteria
Abstract

New ethyl 3,4-dihydro-3-oxo-4,6,7-trisubstituted-2H-1,4-benzoxazine-2-acetate derivatives were synthesized and their structures were elucidated by IR, (1)H NMR and mass spectral data. Antimicrobial activity of the compounds was investigated by using the method of twofold serial dilution technique against different Gram-positive, Gram-negative bacteria and some Candida species in comparison to standard drugs. Microbiological results indicated that the synthesized compounds possessed a broad spectrum of activity having MIC values of 6.25-100 micro g/ml against the tested microorganisms. The QSAR analysis of a set of these compounds tested for growth inhibitory activity against Candida krusei was performed by using the computer-assisted multiple regression procedure. The activity contributions for substituent effects of these compounds were determined from the correlation equation for predictions of the lead optimization.

Published
2007
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12. Synthesis and Structure—Activity Relationships of New Antimicrobial Active Multisubstituted Benzazole Derivatives

Author

Esin Aki-Sener, Nejat Ucarturk, Ismail Yalcin, and Ilkay Yildiz-Oren

Subjects
Antifungal, Benzimidazole, Antifungal Agents, medicine.drug_class, Microbial Sensitivity Tests, medicine.disease_cause, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Candida albicans, medicine, Organic chemistry, Antibacterial agent, Pharmacology, Benzoxazoles, Bicyclic molecule, Bacteria, biology, Chemistry, Organic Chemistry, General Medicine, Benzoxazole, biology.organism_classification, Antimicrobial, Combinatorial chemistry, Corpus albicans, Anti-Bacterial Agents, Benzothiazole, Staphylococcus aureus, Polar effect, Benzimidazoles
Abstract

A series of multisubstituted benzoxazoles, benzimidazoles, and benzothiazoles ( 5–7 ) as non-nucleoside fused isosteric heterocyclic compounds was synthesized and tested for their antibacterial activities against various Gram-positive and Gram-negative bacteria and antifungal activity against the fungus Candida albicans . Microbiological results indicated that the synthesized compounds possessed a broad spectrum of activity against the tested microorganisms at MIC values between 100 and 3.12 μg/ml. Structure–activity relationships (SAR) studies revealed that benzothiazole ring system enhanced the antimicrobial activity against Staphylococcus aureus . In these sets of non-nucleoside fused heterocyclic compounds electron withdrawing groups at position 5 of the benzazoles increased the activity against C. albicans .

Published
2004
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14. New Class of Steroidal Alkaloids from Fritillaria imperialis

Author

Atta-ur-Rahman, M. Iqbal Choudhary, Y. Tsuda, Ilkay Erdogan, M. Nadeem Akhtar, and Bilge Sener

Subjects
Fritillaria imperialis, biology, Traditional medicine, Metalloporphyrins, Stereochemistry, Chemistry, Plant Science, General Medicine, Horticulture, biology.organism_classification, Ferric Compounds, Biochemistry, Gas Chromatography-Mass Spectrometry, Alkaloids, Fritillaria, Steroids, Steroidal alkaloid, Nuclear Magnetic Resonance, Biomolecular, Molecular Biology
Abstract

Two members of a new class of C-nor-D-homo steroidal alkaloids, impranine (1) and dihydroimpranine (2) along with a new pyridyl-pregnane-type steroidal alkaloid, fetisinine (3) and a known base, korsevine (4) were isolated from the bulbs of Fritillaria imperialis. The structures of the compounds were established on the basis of spectroscopic techniques and some chemical transformations. Compounds 1 and 2 form a new class of steroidal alkaloids, named as "impranane." © 2003 Elsevier Science Ltd. All rights reserved.

Published
2003
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15. Synthesis and Antimicrobial Activity of Some Novel 2,6,7-Trisubstituted-2H-3,4-dihydro-1,4-benzoxazin-3-one Derivatives

Author

Betül Tekiner, Nurten Altanlar, Ismail Yalcin, Esin Aki-Sener, İlkay Ören, and Özlem Temiz Arpaci

Subjects
Antifungal, medicine.drug_class, Chemistry, Stereochemistry, medicine, General Medicine, Antimicrobial, Compound s
Abstract

The synthesis of a new serie s of 2/-1-3 ,4-dihydro- 1 ,4-bcnzoxazin-3-one derivatives 1-8 is accomplished in order to determine their antimicrobial activities and study th eir structure -ac tivit y relati onships (SA R). The sy nthesized compounds have bee n tested in virro against two Gram-positive, three Gram-negative bacteria and the fungu s Candida a/bicans. The in vi rro act ivit y results show that the sy nthesized compounds cxibit MIC va lu es between 50- 12.5 J..lg/mL for th e antimi crob ial activity against the tes ted microorga ni sms. The antibacterial and antifungal act ivities or the co mpounds 1-8 are al so compared to several standard drugs. Virtanen et a/ 1 - 4 have iso lated 2,4-dihydroxy-1 ,4benzoxazin-3-one (DIBOA) as a glycos ide from rye pl ant. Since th en a number of analogous of I ,4benzoxazine have been fo und in nature. Only, limited number of compound s containin g I ,4 -benzoxazin c rin g sys tem have been studi ed for th eir chemotherap euti c actiVIt y. The most interesting observation that ofloxacin molecule posseses th e I ,4benzoxazine rin g system in it s structure 5 · 6 , prompted us to investigate thi s heterocyc li c nuclei to ascertain if it would offer any advantage over the other known clini ca ll y used antimi crobial drugs.

Published
2003
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16. Synthesis and HIV-1 Reverse Transcriptase Inhibitor Activity of Some 2,5,6-Substituted Benzoxazole [cf. (III)] Benzimidazole [cf. (VIII)], Benzothiazole [cf. (X)] and Oxazolo(4,5-b)pyridine Derivatives [cf. (V)]

Author

Ismail Yalcin, Ayseguel Akbay, Oezlem Temiz‐Arpaci, Ilkay Oeren, and Esin Aki-Sener

Subjects
chemistry.chemical_compound, Benzimidazole, chemistry, Reverse-transcriptase inhibitor, Benzothiazole, Stereochemistry, Pyridine, Human immunodeficiency virus (HIV), medicine, General Medicine, Benzoxazole, medicine.disease_cause, medicine.drug
Published
2003
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