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Your search keyword '"Shklyaev, A. A."' showing total 418 results
Start Over Author "Shklyaev, A. A." Journal cheminform
418 results on '"Shklyaev, A. A."'

2. ChemInform Abstract: One-Pot, Three-Component Synthesis of Novel Pyrroloacridinones via Intramolecular ipso Dearomatization-Intramolecular Aza-Michael Addition Sequence

Author

Yuliya S. Rozhkova, Marina A. Ezhikova, Yurii V. Shklyaev, Mikhail I. Kodess, A. A. Gorbunov, and Kristina A. Galata

Subjects
Stereochemistry, Chemistry, Component (thermodynamics), Intramolecular force, Michael reaction, Sequence (biology), General Medicine
Abstract

An attempted conversion of 2,6-di-tert-butylphenol yields the corresponding pyrroloacridinone in trace amounts only.

Published
2015

18. ChemInform Abstract: Ritter Reaction. Synthesis of 1-Substituted 3,3,7,9-Tetramethyl-2-azaspiro[4.5]deca-6,9-dien- and -1,6,9-trien-8-ones and 7-Methoxy-3,3,6,8-tetramethyl-3,4-dihydroisoquinolines

Author

K. A. Galata, Yu. V. Shklyaev, T. S. Vshivkova, and Yu. S. Rozhkova

Subjects
inorganic chemicals, Chemistry, digestive, oral, and skin physiology, General Medicine, Medicinal chemistry, Deca, Ritter reaction, respiratory tract diseases
Abstract

The reaction of aromatic and aliphatic nitrils with phenyl-2-methylpropan-1-oles mediated by sulphuric acid is described.

Published
2014

22. ChemInform Abstract: Five-Membered 2,3-Dioxo Heterocycles. Part 92. Reaction of 3-Aroyl-1H-pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-triones with Ethyl (2Z)-(3,3-Dimethyl-8-oxo-2-azaspiro [4.5]deca-6,9-dien-1-ylidene)ethanoate. Synthesis of Bridged Analogues o

Author

Valeriya V. Konovalova, A. N. Maslivets, Olga G. Stryapunina, Pavel A. Slepukhin, and Yu. V. Shklyaev

Subjects
chemistry.chemical_compound, Chemistry, organic chemicals, fungi, Pyrrolizidine, food and beverages, heterocyclic compounds, General Medicine, complex mixtures, Medicinal chemistry, Deca
Abstract

Derivatives (III) can be regarded as bridged analogs of pyrrolizidine alkaloids, which exhibit important pharmacological properties.

Published
2013

24. ChemInform Abstract: Synthesis of Novel 5,6-Dihydropyrrolo[2,1-a]isoquinolines via Grob Reaction Between (E)-1,1,1-Trifluoro-3-nitro-2-butene and 3,4-Dihydroisoquinolines

Author

Yurii V. Shklyaev, Pavel A. Slepukhin, Vyacheslav Ya. Sosnovskikh, Vladislav Yu. Korotaev, and Alexey Yu. Barkov

Subjects
chemistry.chemical_compound, chemistry, Nitro, General Medicine, 2-Butene, Medicinal chemistry, Catalysis
Abstract

A simple one-step procedure to synthesize 5,6-dihydropyrrolo[2,1-a]isoquinolines such as (III) and (V) without any catalyst is presented.

Published
2013

26. ChemInform Abstract: Retropinacol Rearrangement in the Synthesis of 3,3,4-Trimethyl-2-azaspiro[4.5]deca-1,6,9-trien-8-one Derivatives

Author

O. G. Stryapunina, Yu. V. Shklyaev, and O. A. Maiorova

Subjects
chemistry.chemical_compound, Chemistry, Organic chemistry, Biologically active substances, General Medicine, Anisole, Pyrrole derivatives, Deca
Abstract

With the object to obtaining biologically active substances, the three-component reaction of anisole (I), pivalaldehyde (II) and nitriles (III) is performed.

Published
2012

27. ChemInform Abstract: Spirocyclohexadienones. Part 12. Dienone-Phenol Rearrangement of 1-Substituted 2-Azaspiro[4.5]undeca-1,6,9-trienes and Their Analogues

Author

T. F. Odegova, E. V. Rotermel, Yu. V. Shklyaev, and Vladimir A. Glushkov

Subjects
body regions, chemistry.chemical_compound, Hydrolysis, chemistry, parasitic diseases, fungi, Phenol, General Medicine, Cleavage (embryo), behavioral disciplines and activities, Medicinal chemistry
Abstract

The hydrolytic cleavage of the spiro compounds in acid media is accompanied by dienone—phenol rearrangement to furnish substituted N-(hydroxyphenylethyl)-carboxylic amides.

Published
2012

28. ChemInform Abstract: A Simple Synthesis of the Pentacyclic Lamellarin Skeleton from 3-Nitro-2-(trifluoromethyl)-2H-chromenes and 1-Methyl(benzyl)-3,4-dihydroisoquinolines

Author

Vyacheslav Ya. Sosnovskikh, Mikhail I. Kodess, Pavel A. Slepukhin, Alexey Yu. Barkov, Yurii V. Shklyaev, Vladislav Yu. Korotaev, and Marina A. Ezhikova

Subjects
chemistry.chemical_compound, Trifluoromethyl, chemistry, Simple (abstract algebra), Nitro, Organic chemistry, General Medicine, Skeleton (category theory)
Abstract

A variety of lamellarin-type pentacyclic compounds are prepared by use of Grob synthesis, i.e.

Published
2012

29. ChemInform Abstract: Eugenol and Its Methyl Ether in the Synthesis of 3-Methyl Derivatives of 3,4-Dihydroisoquinoline

Author

A. A. Smolyak, A. A. Gorbunov, and Yu. V. Shklyaev

Subjects
Eugenol, chemistry.chemical_compound, Isoeugenol, chemistry, Yield (chemistry), Organic chemistry, Ether, General Medicine, Propylene oxide
Abstract

3-Methyl derivatives of 1-substituted 3,4-dihydroisoquinoline were obtained proceeding from eugenol and its methyl ether. The propylene oxide in a three-component reaction with veratrol and ethyl cycnoacetate provided the reaction products in a low yield. The isoeugenol in a linear synthesis also gives a low yield of the target compounds.

Published
2011

30. ChemInform Abstract: Neospiroenones. Synthesis of 10,11-Dimethoxy-1,6,6-trimethyl-5,6,8,12b-tetrahydrobenzo [d,f]indol-4(3H)-one and 10,11-Dimethoxy-6,6-dimethyl-1,5,6,12b-tetrahydrobenzo [d,f]indol-2(8H)-one

Author

M. A. El’tsov, A. V. Kharitonova, O. A. Mayorova, Yu. S. Rozhkova, and Yu. V. Shklyaev

Subjects
chemistry.chemical_compound, chemistry, Condensation, General Medicine, Medicinal chemistry, Isobutyraldehyde, Pyrrole derivatives
Abstract

The three-component condensation of anisoles, isobutyraldehyde and arylacetonitriles is studied and mechanistic aspects are discussed.

Published
2011

31. ChemInform Abstract: A Simple Synthesis of the Lamellarin Analogues from 3-Nitro-2-trifluoromethyl-2H-chromenes and 1-Benzyl-3,4-dihydroisoquinolines

Author

Vyacheslav Ya. Sosnovskikh, Yurii V. Shklyaev, Evgeniya S. Yasnova, Alexey Yu. Barkov, and Vladislav Yu. Korotaev

Subjects
chemistry.chemical_compound, Trifluoromethyl, chemistry, Simple (abstract algebra), Nitro, medicine, General Medicine, Drotaverine, Medicinal chemistry, medicine.drug
Abstract

New CF3-containing lamellarin analogues (III) (6 examples) are obtained by the Grob reaction of chromenes (II) with dihydropapaverine (Ia) or drotaverine (Ib).

Published
2011

32. ChemInform Abstract: Three-Component Synthesis of 1-Substituted 6′,7′-Dimethoxy-4′H-spiro[adamantane-2,3′-isoquinolines]

Author

A. A. Gorbunov, Yu. V. Shklyaev, and Yu. S. Rozhkova

Subjects
chemistry.chemical_compound, chemistry, Component (thermodynamics), Adamantane, General Medicine, Medicinal chemistry
Abstract

Title compounds (IV) and (VI) are formed by Ritter-type reaction between 2-epoxymethyleneadamantane (I), 1,2-dimethoxybenzene as activated arene, and nitriles (III) or (V).

Published
2010

33. ChemInform Abstract: Retropinacol Rearrangement in the Synthesis of 3,3,4-Trimethyl-3,4-dihydroisoquinoline Derivatives

Author

O. A. Maiorova, M. Yu. Gilev, and Yu. V. Shklyaev

Subjects
Benzonitrile, chemistry.chemical_compound, Cyanoacetamide, chemistry, Ethyl cyanoacetate, Condensation, Organic chemistry, Sulfuric acid, General Medicine
Abstract

Three-component condensation of veratrole with pivalaldehyde and nitriles (ethyl cyanoacetate, cyanoacetamide, and benzonitrile) in concentrated sulfuric acid leads to the formation of 1-substituted 6,7-dimethoxy-3,3,4-trimethyl-3,4-dihydroisoquinolines.

Published
2010

35. ChemInform Abstract: Reaction of 2,3-Dioxopyrrolo(2,1-a)isoquinolines with o- Phenylenediamine

Author

B. B. Aleksandrov, V. S. Shklyaev, and A. G. Mikhailovskii

Subjects
chemistry.chemical_compound, Oxalyl chloride, Chemistry, o-Phenylenediamine, Organic chemistry, General Medicine, Medicinal chemistry
Abstract

Reaction of 1,2,3,4-tetrahydroisoquinoline enaminoamides with oxalyl chloride gives 2,3-dioxpyrrolo[2,1-a]isoquinolines which react with o-phenylenediamine to give spiro benzimidazolines or condensed quinoxalines, depending on the conditions used.

Published
2010

36. ChemInform Abstract: Reaction of Dichlorocarbene with Substituted 3,4-Dihydroisoquinolines and 1-Methylene-1,2,3,4-tetrahydroisoquinolines

Author

Rafael R. Kostikov, V. S. Shklyaev, Alexander F. Khlebnikov, B. B. Aleksandrov, and M. Yu. Dormidontov

Subjects
Hydrolysis, chemistry.chemical_compound, Dichlorocarbene, Acetic acid, Chemistry, Amide, Organic chemistry, General Medicine, Methylene, Carbene, Medicinal chemistry, Adduct, Enamine
Abstract

Reaction of dichlorocarbene with 3,3-dialkyl-3,4-dihydroisoquinolines results in the formation of gemdichloroazirino[2,1-a]isoquinolines, which are in turn converted to 3-benzazepinones upon hydrolysis. Reaction of dichlorocarbene with the ethyl ester or amide of (3,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-1-ylidene)acetic acid is accompanied by rearrangement of the intermediate carbene adducts at the enamine C=C bond and results in the formation of a 1-azadiene, 3-(3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)-3-chloroacrylic acid ethyl ester, and a spirolactam, 3,3-dimethyl-3-chlorospiro[1,2,3,4-tetrahydroisoquinoline-1,2′-pyrrole]-5′(2′H)-one, respectively.

Published
2010

44. ChemInform Abstract: Reaction of 1-Methylthio-3,4-dihydroisoquinolines with Amines

Author

N. B. Belogub, I. L. Misyura, Vladimir A. Glushkov, and Yu. V. Shklyaev

Subjects
chemistry.chemical_compound, Semicarbazide, Ammonia, Thiourea, chemistry, Anthranilic acid, Organic chemistry, General Medicine
Abstract

A study was carried out on the reaction of 1-methylthio-3,4-dihydroisoquinolines with aromatic and aliphatic amines, thiourea, semicarbazide, and thiosemicarbazide. The reactions with anthranilic acid and 2-amino-3-carboethoxy-4,5-dmeurylthiophene give 6,6-dmethyl-5,6-dihydro-8H-isoquino[1,2-blquinazolin-8-one and 6, 6, 9,10-tetramethyl-5,6-dihydro-8H-benzo[i]thieno[2,3-b]quinolizin-8-one, respectively. 1-Semicarbazido-and 1-thiosemicarbazido-3,4-dihydroisoquinolines were shown to undergo thermal elimination of ammonia to give substituted 1, 2, 4-triazolo [3, 4-a]isoquinolin-3-ones and 1, 2, 4-triazolo[3, 4-ajisoquinoline-3-thiones.

Published
2010

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