1. ChemInform Abstract: Synthesis of Naphthalene and Indene Precursors to Naphthoic and Indenoic Acids
- Author
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Elizabeth R. Bright, Jacob A. Greenberg, Lorraine M. Deck, David L. Vander Jagt, Lisa J. Whalen, Taylor S. Busby, and Robert E. Royer
- Subjects
chemistry.chemical_compound ,chemistry ,Lactate dehydrogenase ,Organic chemistry ,General Medicine ,Indene ,Naphthalene - Abstract
As part of ongoing research to investigate structural requirements for lactate dehydrogenase inhibition by highly substituted naphthoic and indenoic acids, certain naphthalene and indene precursors to those types of compounds are required. Described here are efficient preparations of 1-naphthoic acid precursors 6-benzyl-2,3-dimethoxy-1-propylnaphthalenes, including compounds with substituted benzyl groups and 7-benzyl-2,3-dimethoxy-1-propylnaphthalene. Also described are the syntheses of indenoic acid precursors 2-benzyl-5,6-dimethoxy-7-propyl-1 H -indenes, including compounds with substituted benzyl groups. These compounds were made from the key intermediates 6,7-dimethoxy-5-propyl-1-tetralone, 6,7-dimethoxy-8-propyl-1-tetralone, and 5,6-dimethoxy-4-propyl-1-indanone.
- Published
- 2014