1. ChemInform Abstract: Novel Dehydrative Glycosylation by Using Acid Anhydride and TMSClO4
- Author
-
Shoichi Kusumoto, Masahiro Wakao, Yoshihiko Nakai, and Koichi Fukase
- Subjects
chemistry.chemical_classification ,animal structures ,Glycosylation ,Trichloroacetic anhydride ,Glycoside ,macromolecular substances ,General Medicine ,Acid anhydride ,carbohydrates (lipids) ,chemistry.chemical_compound ,chemistry ,Organic chemistry ,lipids (amino acids, peptides, and proteins) ,Glycosyl ,Lewis acids and bases ,Trifluoroacetic anhydride - Abstract
Novel dehydrative glycosylation with 1-hydroxy sugars as glycosyl donors was achieved. Combination of trifluoroacetic anhydride or trichloroacetic anhydride as dehydrating agents with TMSClO4 as a Lewis acid afforded desired glycosides in good yields. t-Butyldiphenylsilyl and trichloroethoxycarbonyl groups at the 6-position of donors enhance α-selectivity of the glycosylation.
- Published
- 2010
- Full Text
- View/download PDF