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2. ChemInform Abstract: Discovery of Potent T-Type Calcium Channel Blocker

Author

Dong Jun Joo, Jungahn Kim, Jae Yeol Lee, Han Na Seo, Yoonjee Kim, So Ha Lee, Hyewhon Rhim, Ja Youn Choi, and Yun Jeong Choe

Subjects
chemistry.chemical_compound, Chemistry, Blocking (radio), Stereochemistry, Calcium channel, T-type calcium channel, Kurtoxin, Molecule, Potency, General Medicine, Combinatorial chemistry
Abstract

The intensive SAR study of 3,4-dihydroquinazoline series led to the most potent compound 10 (KYS05090: IC(50)=41+/-1 nM) against T-type calcium channel and its potency is nearly comparable to that of Kurtoxin. As a small organic molecule, this compound showed the highest blocking activity reported to date.

Published
2008
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