1. A Small‐Molecule Diketopyrrolopyrrole‐Based Dye for in vivo NIR‐IIa Fluorescence Bioimaging.
- Author
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Yang, Zhicheng, Fan, Xiaoxiao, Li, He, Li, Xinsheng, Li, Sifan, Zhang, Zhiyun, Lin, Hui, Qian, Jun, and Hua, Jianli
- Subjects
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FLUORESCENCE angiography , *FLUORESCENCE , *SMALL intestine , *CEREBRAL angiography , *INTESTINAL tumors , *FLUOROPHORES - Abstract
Organic small‐molecule fluorophores with near‐infrared IIa (NIR‐IIa) emission have great potential in pre‐clinical detection and inoperative imaging due to the high‐spatial resolution and deep penetration. However, developments of the NIR‐IIa fluorophores are still facing considerable challenges. In this work, a series of diketopyrrolopyrrole (DPP)‐based fluorophores were designed and synthesized. Subsequently, nanomaterial T25@F127 with significant NIR‐IIa emission properties was rationally prepared by encapsulating DPP‐based fluorophore T25, and was selected for fluorescence angiography and cerebral vascular microscopic imaging with nearly 800 μm penetrating depth and excellent signal‐background ratio of 4.07 and 2.26 (at 250 and 400 μm), respectively. Furthermore, the nanomaterial T25@cRGD with tumor targeting ability can image tiny metastatic tumor on intestine with a small size of 0.3 mm×1.0 mm and high‐spatial resolution (SBR=3.84). This study demonstrates that the nanomaterials which encapsulated T25 behave as excellent NIR‐IIa fluorescence imaging agents and have a great potential for in vivo biological application. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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