1. Denitrative Hydroxylation of Unactivated Nitroarenes.
- Author
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Duff, Lee, Meakin, Harry, Richardson, Adam, Greener, Andrew J., Smith, George W. A., Ocaña, Ivan, Chechik, Victor, and James, Michael J.
- Subjects
- *
NITROAROMATIC compounds , *HYDROXYLATION , *RADICAL anions - Abstract
A one-step method for the conversion of nitroarenes into phenols under operationally simple, transition-metal-free conditions is described. This denitrative functionalization protocol provides a concise and economical alternative to conventional three-step synthetic sequences. Experimental and computational studies suggest that nitroarenes may be substituted by an electron-catalysed radical-nucleophilic substitution (SRN1) chain mechanism. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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