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Deracemization extended to racemic‐compound‐forming systems is demonstrated. We present here the first results of an alternative for the resolution of systems that exhibit a stable racemic compound but also a closely related conglomerate‐forming system. If the couples of enantiomers forming the racemic compound and the enantiomers of the stable conglomerate can syncrystallize in mirror‐related partial solid solutions, it is possible to deracemize the racemic mixture of mixed crystals to access to a single handedness. The evidence for this possibility is given in three examples by using temperature‐cycling‐induced deracemization. [ABSTRACT FROM AUTHOR]

Keywords: chiral resolution; deracemization; heterogeneous equilibria; racemic compounds; solid solutions EN chiral resolution deracemization heterogeneous equilibria racemic compounds solid solutions 1 1 1 05/16/23 20230511 NES 230511 B Starting from a deracemizable conglomerate b (blue and red cubes), it is possible to substitute in the solid-state part of the blue and red enantiomers with chemically related enantiomers (green and yellow cubes) that crystallize as a racemic compound. The mirror-image solid solutions (enriched mixed crystals) could be deracemized by temperature cycling (deracemized mixed crystals). Cover Feature: Use of Conglomerate Mixed Crystals to Deracemize a Stable Racemic-Compound-Forming System (Chem. Eur. J. 27/2023). [Extracted from the article]