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Photothermal therapy (PTT) has drawn extensive attention owing to its noninvasive and great tissue penetration depth. However, the physical encapsulation of photothermal agents may lead to their rapid release. Dual‐functional hydrogel systems that integrate functions and carriers can potentially solve this problem. In this work, we successfully developed a dual‐functional guanosine(G)‐based hydrogel integrating the photothermal effect and localized delivery by introducing dynamic borate ester utilizing the photothermal property of PDA‐AuNPs and the self‐assembly ability of G. Both in vitro and in vivo results confirmed that the GBPA hydrogel not only exhibited excellent photothermal toxicity, stability, injectability, and biocompatibility, but also possessed high photothermal antitumor activity. These results suggested that the GBPA hydrogel could be used as a dual‐functional hydrogel integrating photothermal effect and localized delivery in one system, which would possibly provide a new opportunity for the design of new dual‐functional hydrogels for highly efficient cancer therapy. [ABSTRACT FROM AUTHOR]

Abstract: Recently, supramolecular hydrogels have attracted increasing interest owing to their tunable stability and inherent biocompatibility. However, only few studies have been reported in the literature on self‐healing supramolecular nucleoside hydrogels, compared to self‐healing polymer hydrogels. In this work, we successfully developed a self‐healing supramolecular nucleoside hydrogel obtained by simply mixing equimolar amounts of guanosine (G) and isoguanosine (isoG) in the presence of K+. The gelation properties have been studied systematically by comparing different alkali metal ions as well as mixtures with different ratios of G and isoG. To this end, rheological and phase diagram experiments demonstrated that the co‐gel not only possessed good self‐healing properties and short recovery time (only 20 seconds) but also could be formed at very low concentrations of K+. Furthermore, nuclear magnetic resonance (NMR), powder X‐ray diffraction (PXRD), and circular dichroism (CD) spectroscopy suggested that possible G2isoG2‐quartet structures occurred in this self‐healing supramolecular nucleoside hydrogel. This co‐gel, to some extent, addressed the problem of isoguanosine gels for the applications in vivo, which showed the potential to be a new type of drug delivery system for biomedical applications in the future. [ABSTRACT FROM AUTHOR]

Keywords: Borate ester bond; dynamic covalent bond; guanosine hydrogel; PDA-AuNPs; photothermal therapy EN Borate ester bond dynamic covalent bond guanosine hydrogel PDA-AuNPs photothermal therapy 1 1 1 08/03/22 20220801 NES 220801 B A dual-functional guanosine-based hydrogel b (GBPA) integrating the photothermal property of PDA-AuNPs and the self-assembly ability of G by introducing dynamic borate ester was developed. Borate ester bond, dynamic covalent bond, guanosine hydrogel, PDA-AuNPs, photothermal therapy Cover Feature: Guanosine-based Hydrogel Integrating Photothermal Effect of PDA-AuNPs through Dynamic Borate Bond for Photothermal Therapy of Cancer (Chem. [Extracted from the article]