1. Multifunctional DNA Origami Nanoplatforms for Drug Delivery.
- Author
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Lu, Xuehe, Liu, Jianbing, Wu, Xiaohui, and Ding, Baoquan
- Subjects
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DNA folding , *DNA nanotechnology , *GENE therapy , *DRUGS , *NANOCARRIERS - Abstract
DNA nanotechnology has been employed in the construction of self‐assembled nano‐biomaterials with uniform size and shape for various biological applications, such as bioimaging, diagnosis, or therapeutics. Herein, recent successful efforts to utilize multifunctional DNA origami nanoplatforms as drug‐delivery vehicles are reviewed. Diagnostic and therapeutic strategies based on gold nanorods, chemotherapeutic drugs, cytosine–phosphate–guanine, functional proteins, gene drugs, and their combinations for optoacoustic imaging, photothermal therapy, chemotherapy, immunological therapy, gene therapy, and coagulation‐based therapy are summarized. The challenges and opportunities for DNA‐based nanocarriers for biological applications are also discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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