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Your search keyword '"Zhou, Chen-He"' showing total 2 results
Start Over Author "Zhou, Chen-He" Journal chemistry - an asian journal
2 results on '"Zhou, Chen-He"'

2. Ugi Cascade Sequence for the Construction of 3‐Pyrrolin‐2‐one Scaffolds: Anti‐proliferation in Prostate Cancer Cells.

Author

Lei, Jie, Yang, Dong‐Lin, Xu, Jia, Li, Jie, Zhang, Geng‐Yuan, Xiong, Xu, Zhou, Chen‐He, Xu, Zhi‐Gang, and Chen, Zhong‐Zhu

Subjects
PROSTATE cancer, CELL cycle, CELLULAR signal transduction, CELL lines, CELL cycle regulation
Abstract

Herein, a small series of 3‐pyrrolin‐2‐ones was efficiently synthesized through a three‐step Ugi cascade sequence. This method features readily available substrates, simple aqueous workup procedures and good yields, dramatically improving generality of reaction. Importantly, the newly product N‐benzyl‐2‐(3‐(4‐chlorophenyl)‐4‐methyl‐2‐oxo‐2,5‐dihydro‐1H‐pyrrol‐1‐yl)‐2‐phen‐ylacetamide exhibited potent anti‐proliferation in prostate cancer cell line through G1/S cell cycle arrest and targeted in PI3K/AKT/TSC2 signal pathway. [ABSTRACT FROM AUTHOR]

Published
2022
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