1. New Cytotoxic Triterpenoid Saponins from the Roots of Albizia gummifera (J.F.Gmel.) C.A.Sm.
- Author
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Simo LM, Noté OP, Mbing JN, Aouazou SA, Guillaume D, Muller CD, Pegnyemb DE, and Lobstein A
- Subjects
- Dose-Response Relationship, Drug, Humans, Molecular Conformation, Saponins chemistry, Saponins isolation & purification, Structure-Activity Relationship, Tumor Cells, Cultured, Albizzia chemistry, Apoptosis drug effects, Plant Roots chemistry, Saponins pharmacology
- Abstract
As part of our search for new bioactive saponins from Cameroonian medicinal plants, two new oleanane-type saponins, named gummiferaosides D and E (1 and 2), along with one known saponin, julibroside J
8 (3), were isolated from the roots of Albizia gummifera. Their structures were established on the basis of extensive 1D- and 2D-NMR (1 H- and13 C-NMR, DEPT, COSY, TOCSY, NOESY, HSQC, HSQC-TOCSY, and HMBC) and HR-ESI-MS studies, and by chemical evidence. The apoptotic effect of saponins 1 - 3 was evaluated on the A431 human epidermoid cancer cell. Flow cytometric analyses showed that saponins 1 - 3 induced apoptosis of human epidermoid cancer cell (A431) in a dose-dependent manner., (© 2017 Wiley-VHCA AG, Zurich, Switzerland.)- Published
- 2017
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