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3,3,3-Trifluoropropene derivatives containing a sulfonyl, sulfoximine, or sulfamide substituent at position 1 were used in 1,3-dipolar cycloaddition reaction with ethyl cyanocarboxylate N-oxide generated by thermal decomposition of ethyl oximinochloroacetate, resulting in the formation of isomeric 4(5)-substituted ethyl 5(4)-(trifluoromethyl)-4,5-dihydroisoxazole-3-carboxylates and ethyl 4-(trifluoromethyl) isoxazole-3-carboxylate. [ABSTRACT FROM AUTHOR]

Multicomponent reactions of ethyl 1-trifluoromethyl-2-(trimethylsilyloxy)cyclopropanecarboxylate, isonitriles, and either 2-aminopyridine or amino acids provided imidazo[1,2- a]pyridines or γ-lactams, respectively. This access to trifluoromethyl-substituted heterocycles demonstrates again that siloxycyclopropanes can serve as hidden functionalized aldehydes and that this type of donor-acceptor-substituted cyclopropanes is particularly versatile. [ABSTRACT FROM AUTHOR]

A method is proposed for the synthesis of 3-nitro-2-phenyl-2-(trifluoromethyl)-2 H-chromenes by tandem condensation of salicylic aldehydes with ( E)-3,3,3-trifluoro-1-nitro-2-phenylprop-1-ene in the presence of triethylamine. The example of 3-nitro-2-phenyl-2-(trifluoromethyl)-2 H-chromene was used to demonstrate conjugated addition reactions with enamines, nitromethane, and aniline, which are characteristic for this class of compounds. The structure of the obtained products was confirmed by X-ray structural analysis. [ABSTRACT FROM AUTHOR]

A method for the cyclization of hexafluoroacetone N-phenylimine derivatives with the formation of benzodiazepine analogs containing trifluromethyl groups has been elaborated. The obtained compounds were characterized by the NMR and mass spectral analysis and by the data from X-ray structural analysis. [ABSTRACT FROM AUTHOR]