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This article describes the use ofembossing and “cut-and-stack”methods of assembly, to generate microfluidic devices from omniphobicpaper and demonstrates that fluid flowing through these devices behavessimilarly to fluid in an open-channel microfluidic device. The porosityof the paper to gases allows processes not possible in devices madeusing PDMS or other nonporous materials. Droplet generators and phaseseparators, for example, could be made by embossing “T”-shapedchannels on paper. Vertical stacking of embossed or cut layers ofomniphobic paper generated three-dimensional systems of microchannels.The gas permeability of the paper allowed fluid in the microchannelto contact and exchange with environmental or directed gases. An aqueousstream of water containing a pH indicator, as one demonstration, changedcolor upon exposure to air containing HCl or NH3gases. [ABSTRACT FROM AUTHOR]