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Your search keyword '"Vallet Regí, María"' showing total 22 results
Start Over Author "Vallet Regí, María" Journal chemistry of materials
22 results on '"Vallet Regí, María"'

10. Nanostructure and Bioactivity of Hybrid Aerogels

Author

Salinas, Antonio J., primary, Vallet-Regí, María, additional, Toledo-Fernández, José A., additional, Mendoza-Serna, Roberto, additional, Piñero, Manuel, additional, Esquivias, Luis, additional, Ramírez-Castellanos, Julio, additional, and González-Calbet, José M., additional

Published
2008
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22. Amino-Polysiloxane Hybrid Materials for Bone Reconstruction

Author

Colilla, Montserrat, J. Salinas, Antonio, and Vallet-Regí, María

Abstract

Organic-inorganic hybrid materials containing amino functional groups were prepared as monoliths and their in vitro bioactivity and degradation were investigated using a simulated body fluid (SBF). The amino-polyorganosiloxane hybrids were obtained via sol-gel starting from N-(2-aminoethyl)-3-aminopropyltrimethoxysilane (DAMO). With the addition of -methacryloxypropyl-trimethoxysilane (MPS), hydrolytically stable and flexible polyorganosiloxane networks were obtained. To induce bioactivity, we added calcium to the hybrids as a calcium salt during the synthesis. A nanocrystalline apatite-like phase was formed on the hybrid surfaces after being soaked in SBF. The bioactivity and degradability of calcium-containing hybrids increased as the DAMO:MPS molar ratio increased, because the molar ratio affects both the functional groups and the charge of the hybrid surfaces, as well as the rate of Ca2release to the SBF solution. Zeta-potential () measurements revealed that at physiological pH, the net surface charge of the bioactive hybrids was negative because of a Si-O-group density higher than that of protonated amino groups (NH3and NH2). These new materials are a promising alternative in bone tissue regeneration because of their tailored in vitro bioactivity and degradability and the presence of amino groups that are able to interact with biological entities.

Published
2006
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