1. Functionalized Polyamine Synthesis with Photoredox Catalysis.
- Author
-
Makihara Y, Maeda B, Akiyoshi R, Tanaka D, and Murakami K
- Subjects
- Putrescine, Biological Transport, Spermine, Polyamines, Spermidine
- Abstract
Polyamines, such as putrescine and spermidine, are pivotal in various biological processes across living organisms. Despite their significance, structurally modified polyamines offer a less-explored avenue for discovering bioactive compounds. The limitation is attributed to the synthetic difficulty of accessing functionalized polyamines. In this study, we accomplished photoredox-catalyzed functionalization of polyamines to diversify their structure. The rapid functionalization allows attaching fluorophores to the target polyamine, facilitating the development of molecular probes for advancing chemical biology studies., (© 2024 Wiley-VCH GmbH.)
- Published
- 2024
- Full Text
- View/download PDF