1. Green and Red Brazilian Propolis: Antimicrobial Potential and Anti-Virulence against ATCC and Clinically Isolated Multidrug-Resistant Bacteria
- Author
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Mário Santos, Alexandre Luiz Souto Borges, Gari Vidal Ccana Ccapatinta, Sérgio Ricardo Ambrósio, Renato L. T. Parreira, Rodrigo Cassio Sola Veneziani, Júlia M B Silva, Jennyfer Andrea Aldana Mejía, Thayná de Souza Silva, Carlos Henrique Gomes Martins, Glaucia Hollaender Braun, Jairo Kenupp Bastos, Renato Pereira Orenha, Matheus H Tanimoto, and Andresa Aparecida Berretta
- Subjects
Staphylococcus aureus ,Virulence ,Bioengineering ,Microbial Sensitivity Tests ,01 natural sciences ,Biochemistry ,Propolis ,Microbiology ,Benzophenones ,Anti-Infective Agents ,Bacterial Proteins ,Catalytic Domain ,Drug Resistance, Multiple, Bacterial ,Molecular Biology ,Binding Sites ,biology ,010405 organic chemistry ,Chemistry ,Biofilm ,Hemolysin ,General Chemistry ,General Medicine ,biology.organism_classification ,Antimicrobial ,Catalase ,0104 chemical sciences ,Molecular Docking Simulation ,010404 medicinal & biomolecular chemistry ,Biofilms ,Molecular Medicine ,Coagulase ,Antibacterial activity ,Bacteria ,Brazil - Abstract
Brazilian green and red propolis stand out as commercial products for different medical applications. In this article, we report the antimicrobial activities of the hydroalcoholic extracts of green (EGP) and red (ERP) propolis, as well as guttiferone E plus xanthochymol (8) and oblongifolin B (9) from red propolis, against multidrug-resistant bacteria (MDRB). We undertook the minimal inhibitory (MIC) and bactericidal (MBC) concentrations, inhibition of biofilm formation (MICB50 ), catalase, coagulase, DNase, lipase, and hemolysin assays, along with molecular docking simulations. ERP was more effective by displaying MIC and MBC values
- Published
- 2021