1. Piperidine Catalyzed Four-component Strategy for the Facile Access of Polyfunctionalized 1,4-Dihydropyridines at Ambient Conditions
- Author
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Rathinam Ramesh, Appaswami Lalitha, Raji Madhesh, and Jan Grzegorz Małecki
- Subjects
Dimethyl acetylenedicarboxylate ,Green chemistry ,Nitrile ,010405 organic chemistry ,Chemistry ,Aryl ,General Chemistry ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,Organocatalysis ,Organic chemistry ,Moiety ,Piperidine - Abstract
A highly efficient and practical method has been disclosed for the convenient access of structurally diverse 1,4-dihydropyridines via one-pot, four-component reactions of aryl aldehydes, different C−H activated acidic compounds bearing nitrile moiety, dimethyl acetylenedicarboxylate and aromatic/aliphatic amines using piperidine as an effective organo-base catalyst in ethanol at ambient conditions. This domino synthetic strategy proceeded very smoothly and provided immense advantages, including facile operational procedure, excellent product yields, shorter reaction time and applicability to wide range of substrates. This protocol furnishes an alternate route to construct a library of potent DHPs under the shade of green chemistry principle.
- Published
- 2016
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