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Your search keyword '"Alborzinia, Hamed"' showing total 8 results
Start Over Author "Alborzinia, Hamed" Journal chemmedchem
8 results on '"Alborzinia, Hamed"'

4. Cellular Selectivity and Biological Impact of Cytotoxic Rhodium(III) and Iridium(III) Complexes Containing Methyl‐Substituted Phenanthroline Ligands

Author

Geldmacher, Yvonne, primary, Kitanovic, Igor, additional, Alborzinia, Hamed, additional, Bergerhoff, Katharina, additional, Rubbiani, Riccardo, additional, Wefelmeier, Pascal, additional, Prokop, Aram, additional, Gust, Ronald, additional, Ott, Ingo, additional, Wölfl, Stefan, additional, and Sheldrick, William S., additional

Published
2011
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8. Cellular uptake, cytotoxicity, and metabolic profiling of human cancer cells treated with ruthenium(II) polypyridyl complexes [Ru(bpy)2(N--N)]Cl2 with N--N=bpy, phen, dpq, dppz, and dppn.

Author

Schatzschneider U, Niesel J, Ott I, Gust R, Alborzinia H, and Wölfl S

Subjects
Antineoplastic Agents chemical synthesis, Breast Neoplasms metabolism, Breast Neoplasms pathology, Cell Line, Tumor drug effects, Cell Line, Tumor metabolism, Cell Line, Tumor pathology, Cisplatin chemistry, Cisplatin pharmacology, HT29 Cells, Humans, Organometallic Compounds chemical synthesis, Structure-Activity Relationship, Antineoplastic Agents pharmacology, Organometallic Compounds pharmacology, Pyridines chemistry, Ruthenium chemistry
Abstract

A series of five ruthenium(II) polypyridyl complexes [Ru(bpy)2(N--N)]Cl2 was tested against human HT-29 and MCF-7 cancer cell lines. Cellular uptake efficiency and cytotoxicity were found to increase with the size of the aromatic surface area of the N--N ligand. The most active compound carrying the dppn ligand exhibits a low micromolar IC(50) value against both cell lines comparable to that of cisplatin under similar conditions. Continuous measurement of oxygen consumption, extracellular acidification rate, and impedance of the cell layer with a chip-based sensor system upon exposure to the complexes showed only small changes for the first two parameters throughout the series. A significant and irreversible decrease in impedance was, however, found for the dppn compound. This suggests that its biological activity is related to modifications in cell morphology or cell-cell and cell-matrix contacts.

Published
2008
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