1. Increased in vitro Anti-HIV Activity of Caffeinium-Functionalized Polyoxometalates.
- Author
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Enderle AG, Bosso M, Groß R, Heiland M, Bollini M, Culzoni MJ, Kirchhoff F, Münch J, and Streb C
- Subjects
- Anions chemical synthesis, Anions chemistry, Anti-HIV Agents chemical synthesis, Anti-HIV Agents chemistry, Caffeine chemistry, Dose-Response Relationship, Drug, Microbial Sensitivity Tests, Polyelectrolytes chemical synthesis, Polyelectrolytes chemistry, Anions pharmacology, Anti-HIV Agents pharmacology, Caffeine pharmacology, HIV drug effects, Polyelectrolytes pharmacology
- Abstract
Polyoxometalates (POMs), molecular metal oxide anions, are inorganic clusters with promising antiviral activity. Herein we report increased anti-HIV-1 activity of a POM when electrostatically combined with organic counter-cations. To this end, Keggin-type cerium tungstate POMs have been combined with organic methyl-caffeinium (Caf) cations, and their cytotoxicity, antiviral activity and mode of action have been studied. The novel compound, Caf
4 K[β2 -CeSiW11 O39 ]×H2 O, exhibits sub-nanomolar antiviral activity and inhibits HIV-1 infectivity by acting on an early step of the viral infection cycle. This work demonstrates that combination of POM anions and organic bioactive cations can be a powerful new strategy to increase antiviral activity of these inorganic compounds., (© 2021 The Authors. ChemMedChem published by Wiley-VCH GmbH.)- Published
- 2021
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