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5 results on '"Di Maro, Salvatore"'

1. Cover Picture:tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells (ChemMedChem 5/2013)

Author

Valente, Sergio, primary, Trisciuoglio, Daniela, additional, Tardugno, Maria, additional, Benedetti, Rosaria, additional, Labella, Donatella, additional, Secci, Daniela, additional, Mercurio, Ciro, additional, Boggio, Roberto, additional, Tomassi, Stefano, additional, Di Maro, Salvatore, additional, Novellino, Ettore, additional, Altucci, Lucia, additional, Del Bufalo, Donatella, additional, Mai, Antonello, additional, and Cosconati, Sandro, additional

Published
2013
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2. tert‐Butylcarbamate‐Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells

Author

Valente, Sergio, primary, Trisciuoglio, Daniela, additional, Tardugno, Maria, additional, Benedetti, Rosaria, additional, Labella, Donatella, additional, Secci, Daniela, additional, Mercurio, Ciro, additional, Boggio, Roberto, additional, Tomassi, Stefano, additional, Di Maro, Salvatore, additional, Novellino, Ettore, additional, Altucci, Lucia, additional, Del Bufalo, Donatella, additional, Mai, Antonello, additional, and Cosconati, Sandro, additional

Published
2013
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3. Carprofen Analogues as Sirtuin Inhibitors: Enzyme and Cellular Studies

Author

Mellini, Paolo, primary, Carafa, Vincenzo, additional, Di Rienzo, Barbara, additional, Rotili, Dante, additional, De Vita, Daniela, additional, Cirilli, Roberto, additional, Gallinella, Bruno, additional, Provvisiero, Donatella Paola, additional, Di Maro, Salvatore, additional, Novellino, Ettore, additional, Altucci, Lucia, additional, and Mai, Antonello, additional

Published
2012
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4. Cover Picture: tert-Butylcarbamate-Containing Histone Deacetylase Inhibitors: Apoptosis Induction, Cytodifferentiation, and Antiproliferative Activities in Cancer Cells (ChemMedChem 5/2013).

Author

Valente, Sergio, Trisciuoglio, Daniela, Tardugno, Maria, Benedetti, Rosaria, Labella, Donatella, Secci, Daniela, Mercurio, Ciro, Boggio, Roberto, Tomassi, Stefano, Di Maro, Salvatore, Novellino, Ettore, Altucci, Lucia, Del Bufalo, Donatella, Mai, Antonello, and Cosconati, Sandro

Published
2013
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5. Carprofen analogues as sirtuin inhibitors: enzyme and cellular studies

Author

Barbara Di Rienzo, Salvatore Di Maro, Paolo Mellini, Roberto Cirilli, Vincenzo Carafa, Lucia Altucci, Daniela De Vita, Ettore Novellino, Antonello Mai, Donatella Paola Provvisiero, Bruno Gallinella, Dante Rotili, Mellini, P, Carafa, V, Di Rienzo, B, Rotili, D, De Vita, D, Cirilli, R, Gallinella, B, Provvisiero, Dp, DI MARO, Salvatore, Novellino, E, Altucci, Lucia, Mai, A., P., Mellini, V., Carafa, B., Di Rienzo, D., Rotili, D., De Vita, R., Cirilli, B., Gallinella, D. P., Provvisiero, S., Di Maro, Novellino, Ettore, L., Altucci, and A., Mai

Subjects
Drug, Inhibitor, media_common.quotation_subject, Carbazoles, Antineoplastic Agents, Apoptosis, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Sirtuin 2, Sirtuin 1, Tubulin, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Sirtuin, Humans, Carprofen, Histone deacetylase, General Pharmacology, Toxicology and Pharmaceutics, 030304 developmental biology, media_common, Pharmacology, chemistry.chemical_classification, SIRT1/2, 0303 health sciences, U937 cell, biology, Selisistat, Organic Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Apoptosi, Acetylation, 3. Good health, Histone Deacetylase Inhibitors, Enzyme, chemistry, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Tumor Suppressor Protein p53, medicine.drug
Abstract

The best of both: SIRT1/2 inhibitors were developed by combining chemical features of selisistat (SIRT1-selective inhibitor; blue) and carprofen (anti-inflammatory drug; red). The most potent compound (shown) increased acetyl-p53 and acetyl-α-tubulin levels, and induced slight apoptosis at 50 μM in U937 cells, differently from selisistat and carprofen.

Published
2012
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