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1 results on '"Isosorbide pharmacokinetics"'

1. Synthesis of 2-[(18)F]Fluoro-2-deoxyisosorbide 5-mononitrate and Assessment of Its in vivo Biodistribution as Determined by Dynamic Positron Emission Tomography (PET).

Author

Santschi N, Wagner S, Daniliuc C, Hermann S, Schäfers M, and Gilmour R

Subjects
Animals, Isosorbide analysis, Isosorbide chemical synthesis, Isosorbide chemistry, Isosorbide pharmacokinetics, Male, Mice, Mice, Inbred C57BL, Models, Molecular, Molecular Structure, Nitrates chemical synthesis, Nitrates chemistry, Tissue Distribution, Fluorine Radioisotopes chemistry, Isosorbide analogs & derivatives, Nitrates analysis, Nitrates pharmacokinetics, Positron-Emission Tomography
Abstract

Herein we disclose the synthesis of 2-fluoro-2-deoxyisosorbide 5-mononitrate (2F-IS-5MN), a fluorinated analogue of the commonly prescribed vasodilator isosorbide 5-mononitrate (IS-5MN). X-ray structural data for IS-5MN and its C2-epimeric congener IM-5MN are presented together with structural data for 2F-IS-5MN. Radioisotope labeling of 2F-IS-5MN has, for the first time, allowed observation of the in vivo biodistribution of this organic nitrate by means of dynamic positron emission tomography (PET) in wild-type mice., (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2015
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