1. Promising Antifungal and Antibacterial Agents Based on 5-Aryl-2,2'-bipyridines and Their Heteroligand Salicylate Metal Complexes: Synthesis, Bioevaluation, Molecular Docking
- Author
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Sophia S. Borisevich, Valery N. Charushin, Victor I. Saloutin, N. P. Evstigneeva, Dmitry S. Kopchuk, Evgeny V. Shchegolkov, Grigory V. Zyryanov, Irina V. Shchur, M. V. Ulitko, Maria I. Savchuk, Yanina V. Burgart, Oleg N. Chupakhin, N. A. Gerasimova, N. V. Kungurov, and Natalia Zilberberg
- Subjects
Antifungal ,Antifungal Agents ,Stereochemistry ,medicine.drug_class ,Cell Survival ,Microbial Sensitivity Tests ,Biochemistry ,DNA gyrase ,Metal ,Minimum inhibitory concentration ,chemistry.chemical_compound ,Mice ,Structure-Activity Relationship ,Coordination Complexes ,Metals, Heavy ,Drug Discovery ,medicine ,Animals ,Humans ,General Pharmacology, Toxicology and Pharmaceutics ,Pharmacology ,biology ,Dose-Response Relationship, Drug ,Molecular Structure ,Chemistry ,Aryl ,Organic Chemistry ,Biofilm ,Fungi ,Antimicrobial ,biology.organism_classification ,Neisseria gonorrhoeae ,Salicylates ,Anti-Bacterial Agents ,Molecular Docking Simulation ,HEK293 Cells ,visual_art ,visual_art.visual_art_medium ,Molecular Medicine ,Bacteria - Abstract
A series of new 5-aryl-2,2'-bipyridines and their (polyfluoro)salicylate complexes of Cu(II), Co(II) and Mn(II) were synthesized. Their antimicrobial activity was evaluated in vitro against six strains of Trichophytons, E. floccosum, M. canis, C. ablicans and Gram-negative bacteria N. gonorrhoeae. Among azo-ligands, Ph-bipy and Tol-bipy showed promising antifungal activity (minimum inhibitory concentration (MIC)
- Published
- 2021