1. Synergism of CAY-1 with Amphotericin B and Itraconazole
- Author
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John M. Bland, Stephen M. Boue, A.J. De Lucca, C. B. Vigo, Thomas J. Walsh, and Thomas E. Cleveland
- Subjects
Antifungal Agents ,Time Factors ,Itraconazole ,Aspergillus flavus ,Microbial Sensitivity Tests ,Aspergillus fumigatus ,Microbiology ,food ,Drug Resistance, Fungal ,Amphotericin B ,Candida albicans ,Drug Discovery ,medicine ,Pharmacology (medical) ,Pharmacology ,biology ,Aspergillus niger ,Drug Synergism ,General Medicine ,Saponins ,biology.organism_classification ,Corpus albicans ,food.food ,Cayenne pepper ,Drug Combinations ,Infectious Diseases ,Oncology ,Steroids ,Plant Preparations ,Capsicum ,medicine.drug - Abstract
Background: CAY-1 is a fungicidal saponin from cayenne pepper whose mode of action differs from amphotericin B (AB) and itraconazole (IT). This work determined CAY-1 synergism with AB or IT. Methods: CAY-1 was purified and used in checkerboard microdilution studies where CAY-1 and AB or IT were mixed with nongerminated (NG) and germinating (G) conidia of three Aspergillus species and Candida albicans. Inhibition was visually determined at 24 and 48 h. Results: CAY-1 had predominantly additive-synergistic interaction with AB or IT against the Aspergillus NG and G conidia. Excellent synergy between CAY-1 and AB occurred at 24 and 48 h against C. albicans. Results suggest CAY-1 enhances AB and IT efficacy.
- Published
- 2006
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