1. Overexpression of MAC30 in the Cytoplasm of Oral Squamous Cell Carcinoma Predicts Nodal Metastasis and Poor Differentiation
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Dong-Sheng Cui, Xiao-Feng Sun, Da-Wei Wang, Hong Zhang, Yan-Hong Yang, Bao-Yong Yan, Zhen-Long Zhu, and Ming-Wei Wang
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Adult ,Male ,Cytoplasm ,Medicin och hälsovetenskap ,Pathology ,medicine.medical_specialty ,Colorectal cancer ,Cellular differentiation ,Medical and Health Sciences ,Metastasis ,Sex Factors ,Drug Discovery ,medicine ,Carcinoma ,Humans ,Pharmacology (medical) ,Basal cell ,Aged ,Pharmacology ,business.industry ,Nodal metastasis ,Age Factors ,Mouth Mucosa ,Membrane Proteins ,Cell Differentiation ,General Medicine ,Middle Aged ,Prognosis ,medicine.disease ,stomatognathic diseases ,Infectious Diseases ,Oncology ,Lymphatic Metastasis ,Carcinoma, Squamous Cell ,Female ,Mouth Neoplasms ,Lymph Nodes ,Lymph ,business - Abstract
Background: Expression of the meningioma-associated protein (MAC30) was increased in several types of tumors, including esophageal, gastric and colon tumors, compared to normal tissue. MAC30 expression levels gradually increased from normal colorectal mucosa to primary colorectal cancer and colorectal cancer spreading to the lymph nodes. MAC30 expression was related to survival in patients with colorectal cancer. However, there is no study on MAC30 in oral squamous cell carcinoma (OSCC). Methods: Therefore, MAC30 expression in OSCC was investigated and possible associations of MAC30 expression with clinicopathological variables in OSCC have been analyzed. MAC30 expression was immunohistochemically examined in 20 normal oral mucosa and 43 OSCC specimens. Results: Expression levels of MAC30 in the cytoplasm markedly increased from normal oral epithelial cells to primary OSCC. Strong cytoplasmic staining was significantly higher in primary OSCC compared to normal oral mucosa samples (51 vs. 20%, p = 0.019). Furthermore, MAC30 expression levels in primary tumors of patients with lymph node metastasis exceeded levels in those without metastasis (65 vs. 35%, p = 0.048), and MAC30 expression in poorly differentiated tumors was higher than in well-differentiated ones (90 vs. 39%, p = 0.005). Conclusion: Overexpression of MAC30 in the cytoplasm of OSCC may predict nodal metastasis and poor differentiation. Original Publication:BY Yan, DW Wang, ZL Zhu, YH Yang, MW Wang, DS Cui, Hong Zhang and Xiao-Feng Sun, Overexpression of MAC30 in the Cytoplasm of Oral Squamous Cell Carcinoma Predicts Nodal Metastasis and Poor Differentiation, 2010, Chemotherapy, (56), 6, 424-428.http://dx.doi.org/10.1159/000317582Copyright: S. Karger AGhttp://www.karger.com/
- Published
- 2010
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