1. Targeting Microbiome: An Alternative Strategy for Fighting SARS-CoV-2 Infection.
- Author
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Spagnolello, Ornella, Pinacchio, Claudia, Santinelli, Letizia, Vassalini, Paolo, Innocenti, Giuseppe Pietro, De Girolamo, Gabriella, Fabris, Silvia, Giovanetti, Marta, Angeletti, Silvia, Russo, Alessandro, Mastroianni, Claudio M., Ciccozzi, Massimo, Ceccarelli, Giancarlo, and d'Ettorre, Gabriella
- Subjects
SARS-CoV-2 ,COVID-19 ,GUT microbiome ,INFECTION ,PROBIOTICS ,VACCINE effectiveness - Abstract
Respiratory and gastrointestinal symptoms are the predominant clinical manifestations of the coronavirus disease 2019 (COVID-19). Infecting intestinal epithelial cells, the severe acute respiratory syndrome coronavirus-2 may impact on host's microbiota and gut inflammation. It is well established that an imbalanced intestinal microbiome can affect pulmonary function, modulating the host immune response ("gut-lung axis"). While effective vaccines and targeted drugs are being tested, alternative pathophysiology-based options to prevent and treat COVID-19 infection must be considered on top of the limited evidence-based therapy currently available. Addressing intestinal dysbiosis with a probiotic supplement may, therefore, be a sensible option to be evaluated, in addition to current best available medical treatments. Herein, we summed up pathophysiologic assumptions and current evidence regarding bacteriotherapy administration in preventing and treating COVID-19 pneumonia. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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