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3. Clinical Markers Associated With Risk of Suicide or Drug Overdose Among Individuals With Smoking Exposure: A Longitudinal Follow-up Study of the COPDGene Cohort

Author

Crapo, James D., Silverman, Edwin K., Make, Barry J., Regan, Elizabeth A., Beaty, Terri H., Castaldi, Peter J., Cho, Michael H., DeMeo, Dawn L., El Boueiz, Adel, Foreman, Marilyn G., Ghosh, Auyon, Hayden, Lystra P., Hersh, Craig P., Hetmanski, Jacqueline, Hobbs, Brian D., Hokanson, John E., Kim, Wonji, Laird, Nan, Lange, Christoph, Lutz, Sharon M., McDonald, Merry-Lynn, Prokopenko, Dmitry, Moll, Matthew, Morrow, Jarrett, Qiao, Dandi, Saferali, Aabida, Sakornsakolpat, Phuwanat, Wan, Emily S., Yun, Jeong, Centeno, Juan Pablo, Charbonnier, Jean-Paul, Coxson, Harvey O., Galban, Craig J., Han, MeiLan K., Hoffman, Eric A., Humphries, Stephen, Jacobson, Francine L., Judy, Philip F., Kazerooni, Ella A., Kluiber, Alex, Lynch, David A., Nardelli, Pietro, Newell, John D., Jr., Notary, Aleena, Oh, Andrea, Ross, James C., San Jose Estepar, Raul, Schroeder, Joyce, Sieren, Jered, Stoel, Berend C., Tschirren, Juerg, Van Beek, Edwin, van Ginneken, Bram, van Rikxoort, Eva, Sanchez-Ferrero, Gonzalo Vegas, Veitel, Lucas, Washko, George R., Wilson, Carla G., Jensen, Robert, Strand, Matthew, Crooks, Jim, Pratte, Katherine, Khatiwada, Aastha, Austin, Erin, Kinney, Gregory, Young, Kendra A., Bhatt, Surya P., Bon, Jessica, Diaz, Alejandro A., Make, Barry, Murray, Susan, Regan, Elizabeth, Soler, Xavier, Bowler, Russell P., Kechris, Katerina, Banaei-Kashani, Farnoush, Curtis, Jeffrey L., Pernicano, Perry G., Hanania, Nicola, Atik, Mustafa, Boriek, Aladin, Guntupalli, Kalpatha, Guy, Elizabeth, Parulekar, Amit, Hersh, Craig, Washko, George, Barr, R. Graham, Austin, John, D’Souza, Belinda, Thomashow, Byron, MacIntyre, Neil, Jr., McAdams, H. Page, Washington, Lacey, McEvoy, Charlene, Tashjian, Joseph, Wise, Robert, Brown, Robert, Hansel, Nadia N., Horton, Karen, Lambert, Allison, Putcha, Nirupama, Casaburi, Richard, Adami, Alessandra, Budoff, Matthew, Fischer, Hans, Porszasz, Janos, Rossiter, Harry, Stringer, William, Sharafkhaneh, Amir, Lan, Charlie, Wendt, Christine, Bell, Brian, Kunisaki, Ken M., Flenaugh, Eric L., Gebrekristos, Hirut, Ponce, Mario, Terpenning, Silanath, Westney, Gloria, Bowler, Russell, Rosiello, Richard, Pace, David, Criner, Gerard, Ciccolella, David, Cordova, Francis, Dass, Chandra, D’Alonzo, Gilbert, Desai, Parag, Jacobs, Michael, Kelsen, Steven, Kim, Victor, Mamary, A. James, Marchetti, Nathaniel, Satti, Aditi, Shenoy, Kartik, Steiner, Robert M., Swift, Alex, Swift, Irene, Vega-Sanchez, Maria Elena, Dransfield, Mark, Bailey, William, Iyer, Anand, Nath, Hrudaya, Wells, J. Michael, Conrad, Douglas, Yen, Andrew, Comellas, Alejandro P., Hoth, Karin F., Newell, John, Jr., Thompson, Brad, Kazerooni, Ella, Labaki, Wassim, Galban, Craig, Vummidi, Dharshan, Billings, Joanne, Begnaud, Abbie, Allen, Tadashi, Sciurba, Frank, Chandra, Divay, Weissfeld, Joel, Anzueto, Antonio, Adams, Sandra, Maselli-Caceres, Diego, Ruiz, Mario E., Singh, Harjinder, Adviento, Brigid A., Iyer, Anand S., Kinney, Gregory L., Hanania, Nicola A., Lowe, Katherine E., Holm, Kristen E., Yohannes, Abebaw M., Shinozaki, Gen, and Fiedorowicz, Jess G.

Published
2023
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4. Quantitative Interstitial Abnormality Progression and Outcomes in the Genetic Epidemiology of COPD and Pittsburgh Lung Screening Study Cohorts

Author

Choi, Bina, Adan, Najma, Doyle, Tracy J., San José Estépar, Ruben, Harmouche, Rola, Humphries, Stephen M., Moll, Matthew, Cho, Michael H., Putman, Rachel K., Hunninghake, Gary M., Kalhan, Ravi, Liu, Gabrielle Y., Diaz, Alejandro A., Mason, Stefanie E., Rahaghi, Farbod N., Pistenmaa, Carrie L., Enzer, Nicholas, Poynton, Clare, Sánchez-Ferrero, Gonzalo Vegas, Ross, James C., Lynch, David A., Martinez, Fernando J., Han, MeiLan K., Bowler, Russell P., Wilson, David O., Rosas, Ivan O., Washko, George R., San José Estépar, Raúl, and Ash, Samuel Y.

Published
2023
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5. Longitudinal Association Between Muscle Loss and Mortality in Ever Smokers

Author

Crapo, James D., Silverman, Edwin K., Cummings, Sara, Madden, Kelley, Make, Barry J., Nabbosa, Juliet, Port, Emily, Rashdi, Serine, Regan, Elizabeth A., Stepp, Lori, Watts, Shandi, Weaver, Michael, Beaty, Terri, Bowler, Russell P., Curtis, Jeffrey L., Han, MeiLan K., Hokanson, John E., Lynch, David A., Strand, Matthew J., Anderson, Gary, Bleecker, Eugene R., Coxson, Harvey O., Crystal, Ronald G., Hogg, James C., Province, Michael A., Rennard, Stephen I., Croxton, Thomas, Gan, Weiniu, Postow, Lisa A., Viviano, Lisa M., Costa-Davis, Corinne, Malanga, Elisha, Prieto, Delia, Tal-Singer, Ruth, Farzadegan, Homayoon, Hadji, Akila, Sathe, Leena, Baraghoshi, David, Chen, Grace, Crooks, James, Knowles, Ruthie, Pratte, Katherine, Wilson, Carla, Zelarney, Pearlanne T., Kechris, Katerina J., Leach, Sonia, Austin, Erin E., Czizik, Annika, Kinney, Gregory, Li, Yisha, Lutz, Sharon M., Ragland, Margaret F., Richmond, Nicole, Young, Kendra A., Cho, Michael, Castaldi, Peter J., Glass, Kimberly, Hersh, Craig, Kim, Wonji, Liu, Yang-Yu, Hersh, Craig P., Bidinger, Jacqueline, Cho, Michael H., Conrad, Douglas, DeMeo, Dawn L., El-Boueiz, Adel R., Foreman, Marilyn G., Ghosh, Auyon, Hahn, Georg, Hansel, Nadia N., Hayden, Lystra P., Hobbs, Brian, Kim, Woori, Lange, Christoph, McDonald, Merry- Lynn, McGeachie, Michael, Moll, Matthew, Morris, Melody, Patsopoulos, Nikolaos A., Qiao, Dandi, Ruczinski, Ingo, Wan, Emily S., Dy, Jennifer G., Fain, Sean B., Ginsburg, Shoshana, Hoffman, Eric A., Humphries, Stephen, Judy, Philip F., Stefanie Mason, Alex Kluiber, Oh, Andrea, Poynton, Clare, Reinhardt, Joseph M., Ross, James, San Jose Estepar, Raul, Schroeder, Joyce D., Sitek, Arkadiusz, Steiner, Robert M., van Beek, Edwin, Ginneken, Bram van, van Rikxoort, Eva, Washko, George R., Jensen, Robert, John E. Hokanson, Co-Chair, Bhatt, Surya P., Casaburi, Richard, Kim, Victor, Putcha, Nirupama, Han, MeiLan, Bon, Jessica, Diaz, Alejandro A., Regan, Elizabeth, Anzueto, Antonio, Bailey, William C., Criner, Gerard J., Dransfield, Mark T., Kinney, Greg, Sprenger, Kim, Benos, Takis, Hanania, Nicola A., Hoth, Karin F., Lambert, Allison, Lowe, Katherine, Oates, Gabriela, Parekh, Trisha, Westney, Gloria, Young, Kendra, Balasubramanian, Aparna, Boriek, Aladin, Fawzy, Ashraf, Jacobson, Francine, LaFon, David C., MacIntyre, Neil, Maselli-Caceres, Diego, McCormack, Meredith C., McDonald, Merry-Lynn, Sciurba, Frank, Soler, Xavier, Tejwani, Vickram, van Beek, Edwin JR., Wade, Raymond C., Wells, Mike, Wendt, Chris H., Yun, Jeong H., Zhang, Jingzhou, Gillenwater, Lucas, Lowe, Katherine E., Pratte, Katherine A., Ragland, Margaret, Attaway, Amy, Mason, Stefanie, Rossiter, Harry B., Saha, Punam Kumar, Wilson, Ava, Amaza, Hannatu, Baldomero, Adrienne, Mamary, A. James, O’Brien, James, Wise, Robert A., Eakin, Michelle, Fiedorowicz, Jess G., Henkle, Ben, Holm, Kristen, Iyer, Anand, Kunisaki, Ken M., McEvoy, Charlene, Mkorombindo, Takudzwa, Shinozaki, Gen, Yohannes, Abebaw, Hobbs, Brian D., Miller, Bruce E., Retson, Tara, McCloskey, Lisa, Pernicano, Perry G., Atik, Mustafa, Bertrand, Laura, Monaco, Thomas, Narendra, Dharani, Lenge de Rosen, Veronica V., Badu-Danso, Kwame, Jacobson, Francine L., Kaufman, Laura, Maguire, Cherie, Struble, Sophie, Wilson, Seth, Barr, R. Graham, Almonte, Casandra, Austin, John H.M., Gomez Blum, Maria Lorena, D’Souza, Belinda M., Florez, Emilay, Martinez, Rodney, MacIntyre, Neil, Jr., Curry, Wendy, McAdams, H. Page, Reikofski, Charlotte V., Washington, Lacey, Brown, Robert, Clare, Cheryl, Daniel, Marie, Horton, Karen, Ting “Tony” Lin, Cheng, Mirza, Tahira, Scott, Meagan, Shade, Becky, Budoff, Matt, Calmelat, Robert, Cavanaugh, Deborah, Dailing, Chris, Diaz, Leticia, Fischer, Hans, Indelicato, Renee Love, Porszasz, Janos, Soriano, April, Stringer, William, Urrutia, Miriam, Baldomero, Arianne, Bell, Brian, Deconcini, Miranda, Loes, Linda, Phelan, Jonathan, Robichaux, Camille, Sasse, Cheryl, Tashjian, Joseph H., Flenaugh, Eric L., Abson, Kema, Gebrekristos, Hirut, Johnson, Priscilla, Jordan, Jessica, Ponce, Mario, Terpenning, Silanath, Wilson, Derrick, Broadhurst, Grace, Dyer, Debra, Engel, Elena, Finigan, Jay, Hill, Andrew, Jones, Alex, Jones, Ryan, Owen, Jordan, Rosiello, Richard, Andries, Nicole, Charpentier, Mary, Kirk, Diane, Pace, David, Ciccolella, David, Cordova, Francis, Dass, Chandra, D’Alonzo, Gilbert, Davis, Valena, Desai, Parag, Fehrle, Dee, Grabianowski, Carla, Jacobs, Michael, Jameson, Laurie, Jones, Gayle M., Kelsen, Steven, Marchetti, Nathaniel, McGonagle, Francine, Satti, Aditi, Shenoy, Kartik, Sheridan, Regina, Vega-Sanchez, Maria, Wallace, Samantha, Akinseye-kolapo, Samuel, Baker, Matthew, Goggins, Arnissa, McClain, Anny, Nath, Hrudaya, Singh, Satinder P., Sonavane, Sushil K., Westfall, Elizabeth, Gil, Marissa, El Hajjaoui, Tarek, Hsiao, Albert, Martineau, Amber, Mielke, Jenna, Perez, Karl, Querido, Gabriel, Reston, Tara, Yen, Andrew, Comellas, Alejandro, Fortis, Spyridon, Galizia, Mauricio, Garcia, Eric, Keating, Janet, Laroia, Archana, Lee, Changhyun, Meyer, Amber, Mullan, Brian, Nagpal, Prashant, Ofori, Oloigbe, Suiter, Sierra, Mason, Stefanie E., Moreta-Martinez, Rafael, Labaki, Wassim W., San Jose Estepar, Ruben, Make, Barry, and Stringer, Kathleen

Published
2022
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7. Detection and Early Referral of Patients With Interstitial Lung Abnormalities: An Expert Survey Initiative

Author

Abtin, Fereidoun, Antoniou, Katerina, Blackwell, Timothy, Brown, Kevin, Chung, Jonathan, Corte, Tamera, Crestani, Bruno, Crossno, Peter, Culver, Daniel, de Andrade, Joao, Deveraj, Anand, Flaherty, Kevin, Gudmundsson, Gunnar, Hatabu, Hiroto, Jacob, Joe, Johansson, Kerri, Kanne, Jeff, Kazerooni, Ella, Kolb, Martin, Lynch, David, Maher, Toby, Martinez, Fernando, Morais, Antonio, Nathan, Steven D., Noth, Imre, Oldham, Justin, Podolanczuk, Anna, Poletti, Venerino, Ravaglia, Claudia, Renzoni, Elizabetta, Richeldi, Luca, Rubin, Geoffrey, Ryerson, Chris, Sahoo, Debasis, Tomassetti, Sara, Spagnolo, Paolo, Strek, Mary E., Suh, Rob, Sverzellati, Nicola, Valeyre, Dominique, Walsh, Simon, Washko, George, White, Eric S., Hunninghake, Gary M., Goldin, Jonathan G., Kadoch, Michael A., Kropski, Jonathan A., Rosas, Ivan O., Wells, Athol U., Yadav, Ruchi, Lazarus, Howard M., Abtin, Fereidoun G., Corte, Tamera J., de Andrade, Joao A., Johannson, Kerri A., Kolb, Martin R., Lynch, David A., Oldham, Justin M., and Washko, George R.

Published
2022
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10. Emphysema Progression and Lung Function Decline Among Angiotensin Converting Enzyme Inhibitors and Angiotensin-Receptor Blockade Users in the COPDGene Cohort

Author

Crapo, James D., Silverman, Edwin K., Make, Barry J., Regan, Elizabeth A., Beaty, Terri, Begum, Ferdouse, Castaldi, Peter J., Cho, Michael, DeMeo, Dawn L., Boueiz, Adel R., Foreman, Marilyn G., Halper-Stromberg, Eitan, Hayden, Lystra P., Hersh, Craig P., Hetmanski, Jacqueline, Hobbs, Brian D., Hokanson, John E., Laird, Nan, Lange, Christoph, Lutz, Sharon M., McDonald, Merry-Lynn, Parker, Margaret M., Prokopenko, Dmitry, Qiao, Dandi, Sakornsakolpat, Phuwanat, Wan, Emily S., Won, Sungho, Centeno, Juan Pablo, Charbonnier, Jean-Paul, Coxson, Harvey O., Galban, Craig J., Han, MeiLan K., Hoffman, Eric A., Humphries, Stephen, Jacobson, Francine L., Judy, Philip F., Kazerooni, Ella A., Kluiber, Alex, Lynch, David A., Nardelli, Pietro, Newell, John D., Jr., Notary, Aleena, Oh, Andrea, Ross, James C., San Jose Estepar, Raul, Schroeder, Joyce, Sieren, Jered, Stoel, Berend C., Tschirren, Juerg, Van Beek, Edwin, Ginneken, Bramvan, van Rikxoort, Eva, Sanchez-Ferrero, Gonzalo Vegas, Veitel, Lucas, Washko, George R., Wilson, Carla G., Jensen, Robert, Everett, Douglas, Crooks, Jim, Pratte, Katherine, Strand, Matt, Kinney, Gregory, Young, Kendra A., Bhatt, Surya P., Bon, Jessica, Diaz, Alejandro A., Make, Barry, Murray, Susan, Regan, Elizabeth, Soler, Xavier, Bowler, Russell P., Kechris, Katerina, Banaei-Kashani, Farnoush, Curtis, Jeffrey L., Pernicano, Perry G., Hanania, Nicola, Atik, Mustafa, Boriek, Aladin, Guntupalli, Kalpatha, Guy, Elizabeth, Parulekar, Amit, Hersh, Craig, Washko, George, Barr, R. Graham, Austin, John, D’Souza, Belinda, Thomashow, Byron, MacIntyre, Neil, Jr., McAdams, H. Page, Washington, Lacey, Flenaugh, Eric, Terpenning, Silanth, McEvoy, Charlene, Tashjian, Joseph, Wise, Robert, Brown, Robert, Hansel, Nadia N., Horton, Karen, Lambert, Allison, Putcha, Nirupama, Casaburi, Richard, Adami, Alessandra, Budoff, Matthew, Fischer, Hans, Porszasz, Janos, Rossiter, Harry, Stringer, William, Sharafkhaneh, Amir, Lan, Charlie, Wendt, Christine, Bell, Brian, Kunisaki, KenM., Bowler, Russell, Rosiello, Richard, Pace, David, Criner, Gerard, Ciccolella, David, Cordova, Francis, Dass, Chandra, D’Alonzo, Gilbert, Desai, Parag, Jacobs, Michael, Kelsen, Steven, Kim, Victor, Mamary, A. James, Marchetti, Nathaniel, Satti, Aditi, Shenoy, Kartik, Steiner, Robert M., Swift, Alex, Swift, Irene, Vega-Sanchez, Maria Elena, Dransfield, Mark, Bailey, William, Iyer, Anand, Nath, Hrudaya, Wells, J. Michael, Conrad, Douglas, Yen, Andrew, Comellas, Alejandro P., Hoth, Karin F., Newell, John, Jr., Thompson, Brad, Kazerooni, Ella, Labaki, Wassim, Galban, Craig, Vummidi, Dharshan, Billings, Joanne, Begnaud, Abbie, Allen, Tadashi, Sciurba, Frank, Chandra, Divay, Fuhrman, Carl, Weissfeld, Joel, Tejwani, Vickram, Fawzy, Ashraf, Cho, Michael H., Pratte, Katherine A., Humphries, Stephen M., Kinney, Gregory L., and D’Alessio, Franco R.

Published
2021
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11. Pulmonary Arterial Pruning and Longitudinal Change in Percent Emphysema and Lung Function: The Genetic Epidemiology of COPD Study

Author

Crapo, James D., Silverman, Edwin K., Make, Barry J., Regan, Elizabeth A., Beaty, Terri H., Castaldi, Peter J., Cho, Michael H., DeMeo, Dawn L., El Boueiz, Adel, Foreman, Marilyn G., Ghosh, Auyon, Hayden, Lystra P., Hersh, Craig P., Hetmanski, Jacqueline, Hobbs, Brian D., Hokanson, John E., Kim, Wonji, Laird, Nan, Lange, Christoph, Lutz, Sharon M., McDonald, Merry-Lynn, Prokopenko, Dmitry, Moll, Matthew, Morrow, Jarrett, Qiao, Dandi, Saferali, Aabida, Sakornsakolpat, Phuwanat, Wan, Emily S., Yun, Jeong, Centeno, Juan Pablo, Charbonnier, Jean-Paul, Coxson, Harvey O., Galban, Craig J., Han, MeiLan K., Hoffman, Eric A., Humphries, Stephen, Jacobson, Francine L., Judy, Philip F., Kazerooni, Ella A., Kluiber, Alex, Lynch, David A., Nardelli, Pietro, Newell, John D., Jr., Notary, Aleena, Oh, Andrea, Ross, James C., San Jose Estepar, Raul, Schroeder, Joyce, Sieren, Jered, Stoel, Berend C., Tschirren, Juerg, Van Beek, Edwin, Ginneken, Bramvan, van Rikxoort, Eva, Sanchez- Ferrero, Gonzalo Vegas, Veitel, Lucas, Washko, George R., Wilson, Carla G., Jensen, Robert, Everett, Douglas, Crooks, Jim, Pratte, Katherine, Strand, Matt, Austin, Erin, Kinney, Gregory, Young, Kendra A., Bhatt, Surya P., Bon, Jessica, Diaz, Alejandro A., Make, Barry, Murray, Susan, Regan, Elizabeth, Soler, Xavier, Bowler, Russell P., Kechris, Katerina, Banaei-Kashani, Farnoush, Curtis, Jeffrey L., Pernicano, Perry G., Hanania, Nicola, Atik, Mustafa, Boriek, Aladin, Guntupalli, Kalpatha, Guy, Elizabeth, Parulekar, Amit, Hersh, Craig, Washko, George, Barr, R. Graham, Austin, John, D’Souza, Belinda, Thomashow, Byron, MacIntyre, Neil, Jr., McAdams, H. Page, Washington, Lacey, McEvoy, Charlene, Tashjian, Joseph, Wise, Robert, Brown, Robert, Hansel, Nadia N., Horton, Karen, Lambert, Allison, Putcha, Nirupama, Casaburi, Richard, Adami, Alessandra, Budoff, Matthew, Fischer, Hans, Porszasz, Janos, Rossiter, Harry, Stringer, William, Sharafkhaneh, Amir, Lan, Charlie, Wendt, Christine, Bell, Brian, Kunisaki, Ken M., Flenaugh, Eric L., Gebrekristos, Hirut, Ponce, Mario, Terpenning, Silanath, Westney, Gloria, Bowler, Russell, Rosiello, Richard, Pace, David, Criner, Gerard, Ciccolella, David, Cordova, Francis, Dass, Chandra, D’Alonzo, Gilbert, Desai, Parag, Jacobs, Michael, Kelsen, Steven, Kim, Victor, Mamary, A. James, Marchetti, Nathaniel, Satti, Aditi, Shenoy, Kartik, Steiner, Robert M., Swift, Alex, Swift, Irene, Vega-Sanchez, Maria Elena, Dransfield, Mark, Bailey, William, Iyer, Anand, Nath, Hrudaya, Wells, J. Michael, Conrad, Douglas, Yen, Andrew, Comellas, Alejandro P., Hoth, Karin F., Newell, John, Jr., Thompson, Brad, Kazerooni, Ella, Labaki, Wassim, Galban, Craig, Vummidi, Dharshan, Billings, Joanne, Begnaud, Abbie, Allen, Tadashi, Sciurba, Frank, Chandra, Divay, Weissfeld, Joel, Pistenmaa, Carrie L., Nardelli, P., Ash, S.Y., Come, C.E., Diaz, A.A., Rahaghi, F.N., Barr, R.G., Young, K.A., Kinney, G.L., Simmons, J.P., Wade, R.C., Wells, J.M., Hokanson, J.E., Washko, G.R., and San José Estépar, R.

Published
2021
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12. Distinguishing Smoking-Related Lung Disease Phenotypes Via Imaging and Molecular Features

Author

Billatos, Ehab, Ash, Samuel Y., Duan, Fenghai, Xu, Ke, Romanoff, Justin, Marques, Helga, Moses, Elizabeth, Han, MeiLan K., Regan, Elizabeth A., Bowler, Russell P., Mason, Stefanie E., Doyle, Tracy J., San José Estépar, Rubén, Rosas, Ivan O., Ross, James C., Xiao, Xiaohui, Liu, Hanqiao, Liu, Gang, Sukumar, Gauthaman, Wilkerson, Matthew, Dalgard, Clifton, Stevenson, Christopher, Whitney, Duncan, Aberle, Denise, Spira, Avrum, San José Estépar, Raúl, Lenburg, Marc E., and Washko, George R.

Published
2021
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15. Machine Learning and Prediction of All-Cause Mortality in COPD

Author

Moll, Matthew, Qiao, Dandi, Regan, Elizabeth A., Hunninghake, Gary M., Make, Barry J., Tal-Singer, Ruth, McGeachie, Michael.J., Castaldi, Peter J., San Jose Estepar, Raul, Washko, George R., Wells, James M., LaFon, David, Strand, Matthew, Bowler, Russell P., Han, MeiLan.K., Vestbo, Jorgen, Celli, Bartolome, Calverley, Peter, Crapo, James, Silverman, Edwin K., Hobbs, Brian D., and Cho, Michael H.

Published
2020
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17. Machine Learning Characterization of COPD Subtypes: Insights From the COPDGene Study

Author

Crapo, James D., Silverman, Edwin K., Make, Barry J., Regan, Elizabeth A., Beaty, Terri, Begum, Ferdouse, Castaldi, Peter J., Cho, Michael, DeMeo, Dawn L., Boueiz, Adel R., Foreman, Marilyn G., Halper-Stromberg, Eitan, Hayden, Lystra P., Hersh, Craig P., Hetmanski, Jacqueline, Hobbs, Brian D., Hokanson, John E., Laird, Nan, Lange, Christoph, Lutz, Sharon M., McDonald, Merry-Lynn, Parker, Margaret M., Prokopenko, Dmitry, Qiao, Dandi, Sakornsakolpat, Phuwanat, Wan, Emily S., Won, Sungho, Centeno, Juan Pablo, Charbonnier, Jean-Paul, Coxson, Harvey O., Galban, Craig J., Han, MeiLan K., Hoffman, Eric A., Humphries, Stephen, Jacobson, Francine L., Judy, Philip F., Kazerooni, Ella A., Kluiber, Alex, Lynch, David A., Nardelli, Pietro, Newell, John D., Jr., Notary, Aleena, Oh, Andrea, Ross, James C., Estepar, Raul San Jose, Schroeder, Joyce, Sieren, Jered, Stoel, Berend C., Tschirren, Juerg, Van Beek, Edwin, van Ginneken, Bram, van Rikxoort, Eva, Sanchez-Ferrero, Gonzalo Vegas, Veitel, Lucas, Washko, George R., Wilson, Carla G., Jensen, Robert, Everett, Douglas, Crooks, Jim, Pratte, Katherine, Strand, Matt, Kinney, Gregory, Young, Kendra A., Bhatt, Surya P., Bon, Jessica, Diaz, Alejandro A., Make, Barry, Murray, Susan, Regan, Elizabeth, Soler, Xavier, Bowler, Russell P., Kechris, Katerina, Banaei-Kashani, Farnoush, Boueiz, Adel, Yun, Jeong, Washko, George, Cho, Michael H., Kinney, Gregory L., Criner, Gerald J., Dy, Jennifer G., Rennard, Stephen I., Casaburi, Richard, and Crapo, James

Published
2020
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18. Estimated Ventricular Size, Asthma Severity, and Exacerbations: The Severe Asthma Research Program III Cohort

Author

Israel, Elliot, Levy, Bruce, Washko, George, Cernadas, Manuela, Phipatanakul, Wanda, Wenzel, Sally, Fajt, Merritt, Gaston, Benjamin, Chmiel, James, Teague, W. Gerald, Irani, Anne-Marie, Erzurum, Serpil, Khatri, Sumita, Comhair, Suzy, Dweik, Raed, Ross, Kristie, Myers, Ross, Moore, Wendy, Meyers, Deborah, Bleecker, Eugene, Peters, Stephen, Hastie, Annette, Ortega, Victor, Hawkins, Greg, Li, Xingan, Fitzpatrick, Anne, Jarjour, Nazar, Denlinger, Loren, Fain, Sean, Sorkness, Ronald, Castro, Mario, Bacharier, Leonard, Gierada, David, Schechtman, Kenneth, Woods, Jason, Fahy, John, Woodruff, Prescott, Ly, Ngoc, Mauger, David, Ash, Samuel Y., Sanchez-Ferrero, Gonzalo Vegas, Schiebler, Mark L., Rahaghi, Farbod N., Rai, Ashish, Come, Carolyn E., Ross, James C., Colon, Alysha G., Cardet, Juan Carlos, Bleecker, Eugene R., Fahy, John V., Fain, Sean B., Gaston, Benjamin M., Hoffman, Eric A., Jarjour, Nizar N., Lempel, Jason K., Mauger, David T., Tattersall, Matthew C., Wenzel, Sally E., Levy, Bruce D., Washko, George R., and San Jose Estepar, Raul

Published
2020
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19. Objectively Measured Chronic Lung Injury on Chest CT

Author

Harmouche, Rola, Ash, Samuel Y., Putman, Rachel K., Hunninghake, Gary M., San Jose Estepar, Ruben, Martinez, Fernando J., Choi, Augustine M., Lynch, David A., Hatabu, Hiroto, Han, MeiLan K., Bowler, Russell P., Kalhan, Ravi, Rosas, Ivan O., Washko, George R., and San Jose Estepar, Raul

Published
2019
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20. Prediction of acute respiratory disease in current and former smokers with and without COPD.

Author

Bowler, Russell P, Kim, Victor, Regan, Elizabeth, Williams, André AA, Santorico, Stephanie A, Make, Barry J, Lynch, David A, Hokanson, John E, Washko, George R, Bercz, Peter, Soler, Xavier, Marchetti, Nathaniel, Criner, Gerard J, Ramsdell, Joe, Han, MeiLan K, Demeo, Dawn, Anzueto, Antonio, Comellas, Alejandro, Crapo, James D, Dransfield, Mark, Wells, J Michael, Hersh, Craig P, MacIntyre, Neil, Martinez, Fernando, Nath, Hrudaya P, Niewoehner, Dennis, Sciurba, Frank, Sharafkhaneh, Amir, Silverman, Edwin K, van Beek, Edwin JR, Wilson, Carla, Wendt, Christine, and Wise, Robert A

Subjects
Humans, Respiratory Tract Diseases, Pulmonary Disease, Chronic Obstructive, Acute Disease, Hospitalization, Incidence, Proportional Hazards Models, Risk Factors, Longitudinal Studies, Follow-Up Studies, Smoking, Quality of Life, Aged, Middle Aged, United States, Female, Male, Clinical Research, Lung, Chronic Obstructive Pulmonary Disease, Respiratory, Good Health and Well Being, Clinical Sciences, Respiratory System
Abstract

BackgroundThe risk factors for acute episodes of respiratory disease in current and former smokers who do not have COPD are unknown.MethodsEight thousand two hundred forty-six non-Hispanic white and black current and former smokers in the Genetic Epidemiology of COPD (COPDGene) cohort had longitudinal follow-up (LFU) every 6 months to determine acute respiratory episodes requiring antibiotics or systemic corticosteroids, an ED visit, or hospitalization. Negative binomial regression was used to determine the factors associated with acute respiratory episodes. A Cox proportional hazards model was used to determine adjusted hazard ratios (HRs) for time to first episode and an acute episode of respiratory disease risk score.ResultsAt enrollment, 4,442 subjects did not have COPD, 658 had mild COPD, and 3,146 had moderate or worse COPD. Nine thousand three hundred three acute episodes of respiratory disease and 2,707 hospitalizations were reported in LFU (3,044 acute episodes of respiratory disease and 827 hospitalizations in those without COPD). Major predictors included acute episodes of respiratory disease in year prior to enrollment (HR, 1.20; 95% CI, 1.15-1.24 per exacerbation), airflow obstruction (HR, 0.94; 95% CI, 0.91-0.96 per 10% change in % predicted FEV1), and poor health-related quality of life (HR, 1.07; 95% CI, 1.06-1.08 for each 4-unit increase in St. George's Respiratory Questionnaire score). Risks were similar for those with and without COPD.ConclusionsAlthough acute episode of respiratory disease rates are higher in subjects with COPD, risk factors are similar, and at a population level, there are more episodes in smokers without COPD.

Published
2014

22. Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression

Author

Crapo, James, Silverman, Edwin, Make, Barry, Regan, Elizabeth, Beaty, Terri, Laird, Nan, Lange, Christoph, Cho, Michael H., Santorico, Stephanie, Hokanson, John, DeMeo, Dawn, Hansel, Nadia, Hersh, Craig, Castaldi, Peter, McDonald, Merry-Lynn, Wan, Emily, Hardin, Megan, Hetmanski, Jacqueline, Parker, Margaret, Foreman, Marilyn, Hobbs, Brian, Busch, Robert, Boueiz, Adel, Qiao, Dandi, Halper-Stromberg, Eitan, Begum, Ferdouse, Won, Sungho, Lutz, Sharon, Lynch, David A., Coxson, Harvey O., Han, MeiLan K., Hoffman, Eric A., Humphries, Stephen, Jacobson, Francine L., Judy, Philip F., Kazerooni, Ella A., Newell, John D., Jr., Ross, James C., Estépar, Raul José, Stoel, Berend C., Tschirren, Juerg, Rikxoort, Eva van, van Ginneken, Bram, Washko, George R., Wilson, Carla G., Qaisi, Mustafa Al, Gray, Teresa, Kluiber, Alex, Mann, Tanya, Sieren, Jered, Stinson, Douglas, Schroeder, Joyce, Beek, Edwin Van, Jensen, Robert, Everett, Douglas, Faino, Anna, Strand, Matt, Wilson, Carla, Hokanson, John E., Kinney, Gregory, Young, Kendra, Pratte, Katherine, Duca, Lindsey, Curtis, Jeffrey L., Martinez, Carlos H., Pernicano, Perry G., Hanania, Nicola, Alapat, Philip, Bandi, Venkata, Atik, Mustafa, Boriek, Aladin, Guntupalli, Kalpatha, Guy, Elizabeth, Parulekar, Amit, Nachiappan, Arun, Jacobson, Francine, Graham Barr, R., Thomashow, Byron, Austin, John, D’Souza, Belinda, Pearson, Gregory D.N., Rozenshtein, Anna, MacIntyre, Neil, Jr., Washington, Lacey, Page McAdams, H., McEvoy, Charlene, Tashjian, Joseph, Wise, Robert, Brown, Robert, Horton, Karen, Putcha, Nirupama, Casaburi, Richard, Adami, Alessandra, Porszasz, Janos, Fischer, Hans, Budoff, Matthew, Rossiter, Harry, Sharafkhaneh, Amir, Lan, Charlie, Wendt, Christine, Bell, Brian, Westney, Gloria, Berkowitz, Eugene, Bowler, Russell, Lynch, David, Rosiello, Richard, Pace, David, Criner, Gerard, Ciccolella, David, Cordova, Francis, Dass, Chandra, D’Alonzo, Gilbert, Desai, Parag, Jacobs, Michael, Kelsen, Steven, Kim, Victor, James Mamary, A., Marchetti, Nathaniel, Satti, Aditi, Shenoy, Kartik, Steiner, Robert M., Swift, Alex, Swift, Irene, Vega-Sanchez, Maria Elena, Dransfield, Mark, Bailey, William, Michael Wells, J., Bhatt, Surya, Nath, Hrudaya, Ramsdell, Joe, Friedman, Paul, Soler, Xavier, Yen, Andrew, Cornellas, Alejandro, Newell, John, Jr., Thompson, Brad, Han, MeiLan, Kazerooni, Ella, Martinez, Carlos, Billings, Joanne, Allen, Tadashi, Sciurba, Frank, Chandra, Divay, Weissfeld, Joel, Fuhrman, Carl, Bon, Jessica, Anzueto, Antonio, Adams, Sandra, Maselli-Caceres, Diego, Ruiz, Mario E., Chang, Yale, San José Estépar, Raul, Bowler, Russell P., Crapo, James D., DeMeo, Dawn L., Dy, Jennifer G., Silverman, Edwin K., and Castaldi, Peter J.

Published
2018
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23. CT metrics of airway disease and emphysema in severe COPD.

Author

Kim, Woo Jin, Silverman, Edwin K, Hoffman, Eric, Criner, Gerard J, Mosenifar, Zab, Sciurba, Frank C, Make, Barry J, Carey, Vincent, San José Estépar, Raúl, Diaz, Alejandro, Reilly, John J, Martinez, Fernando J, Washko, George R, and NETT Research Group

Subjects
NETT Research Group, Humans, Pulmonary Disease, Chronic Obstructive, Pulmonary Emphysema, Dyspnea, Airway Obstruction, Tomography, X-Ray Computed, Respiratory Function Tests, Total Lung Capacity, Pulmonary Ventilation, Forced Expiratory Volume, Severity of Illness Index, Analysis of Variance, Multivariate Analysis, Probability, Risk Assessment, Sensitivity and Specificity, Cohort Studies, Predictive Value of Tests, Adult, Aged, Middle Aged, Female, Male, Lung, Emphysema, Chronic Obstructive Pulmonary Disease, Clinical Research, 2.1 Biological and endogenous factors, Respiratory, Respiratory System, Clinical Sciences
Abstract

BackgroundCT scan measures of emphysema and airway disease have been correlated with lung function in cohorts of subjects with a range of COPD severity. The contribution of CT scan-assessed airway disease to objective measures of lung function and respiratory symptoms such as dyspnea in severe emphysema is less clear.MethodsUsing data from 338 subjects in the National Emphysema Treatment Trial (NETT) Genetics Ancillary Study, densitometric measures of emphysema using a threshold of -950 Hounsfield units (%LAA-950) and airway wall phenotypes of the wall thickness (WT) and the square root of wall area (SRWA) of a 10-mm luminal perimeter airway were calculated for each subject. Linear regression analysis was performed for outcome variables FEV(1) and percent predicted value of FEV(1) with CT scan measures of emphysema and airway disease.ResultsIn univariate analysis, there were significant negative correlations between %LAA-950 and both the WT (r = -0.28, p = 0.0001) and SRWA (r = -0.19, p = 0.0008). Airway wall thickness was weakly but significantly correlated with postbronchodilator FEV(1)% predicted (R = -0.12, p = 0.02). Multivariate analysis showed significant associations between either WT or SRWA (beta = -5.2, p = 0.009; beta = -2.6, p = 0.008, respectively) and %LAA-950 (beta = -10.6, p = 0.03) with the postbronchodilator FEV(1)% predicted. Male subjects exhibited significantly thicker airway wall phenotypes (p = 0.007 for WT and p = 0.0006 for SRWA).ConclusionsAirway disease and emphysema detected by CT scanning are inversely related in patients with severe COPD. Airway wall phenotypes were influenced by gender and associated with lung function in subjects with severe emphysema.

Published
2009

28. Clinical Markers Associated With Risk of Suicide or Drug Overdose Among Individuals With Smoking Exposure

Author

Adviento, Brigid A., primary, Regan, Elizabeth A., additional, Make, Barry J., additional, Han, MeiLan K., additional, Foreman, Marilyn G., additional, Iyer, Anand S., additional, Bhatt, Surya P., additional, Kim, Victor, additional, Bon, Jessica, additional, Soler, Xavier, additional, Kinney, Gregory L., additional, Hanania, Nicola A., additional, Lowe, Katherine E., additional, Holm, Kristen E., additional, Yohannes, Abebaw M., additional, Shinozaki, Gen, additional, Hoth, Karin F., additional, Fiedorowicz, Jess G., additional, Crapo, James D., additional, Silverman, Edwin K., additional, Beaty, Terri H., additional, Castaldi, Peter J., additional, Cho, Michael H., additional, DeMeo, Dawn L., additional, El Boueiz, Adel, additional, Ghosh, Auyon, additional, Hayden, Lystra P., additional, Hersh, Craig P., additional, Hetmanski, Jacqueline, additional, Hobbs, Brian D., additional, Hokanson, John E., additional, Kim, Wonji, additional, Laird, Nan, additional, Lange, Christoph, additional, Lutz, Sharon M., additional, McDonald, Merry-Lynn, additional, Prokopenko, Dmitry, additional, Moll, Matthew, additional, Morrow, Jarrett, additional, Qiao, Dandi, additional, Saferali, Aabida, additional, Sakornsakolpat, Phuwanat, additional, Wan, Emily S., additional, Yun, Jeong, additional, Centeno, Juan Pablo, additional, Charbonnier, Jean-Paul, additional, Coxson, Harvey O., additional, Galban, Craig J., additional, Hoffman, Eric A., additional, Humphries, Stephen, additional, Jacobson, Francine L., additional, Judy, Philip F., additional, Kazerooni, Ella A., additional, Kluiber, Alex, additional, Lynch, David A., additional, Nardelli, Pietro, additional, Newell, John D., additional, Notary, Aleena, additional, Oh, Andrea, additional, Ross, James C., additional, San Jose Estepar, Raul, additional, Schroeder, Joyce, additional, Sieren, Jered, additional, Stoel, Berend C., additional, Tschirren, Juerg, additional, Van Beek, Edwin, additional, van Ginneken, Bram, additional, van Rikxoort, Eva, additional, Sanchez-Ferrero, Gonzalo Vegas, additional, Veitel, Lucas, additional, Washko, George R., additional, Wilson, Carla G., additional, Jensen, Robert, additional, Strand, Matthew, additional, Crooks, Jim, additional, Pratte, Katherine, additional, Khatiwada, Aastha, additional, Austin, Erin, additional, Kinney, Gregory, additional, Young, Kendra A., additional, Diaz, Alejandro A., additional, Make, Barry, additional, Murray, Susan, additional, Regan, Elizabeth, additional, Bowler, Russell P., additional, Kechris, Katerina, additional, Banaei-Kashani, Farnoush, additional, Curtis, Jeffrey L., additional, Pernicano, Perry G., additional, Hanania, Nicola, additional, Atik, Mustafa, additional, Boriek, Aladin, additional, Guntupalli, Kalpatha, additional, Guy, Elizabeth, additional, Parulekar, Amit, additional, Hersh, Craig, additional, Washko, George, additional, Barr, R. Graham, additional, Austin, John, additional, D’Souza, Belinda, additional, Thomashow, Byron, additional, MacIntyre, Neil, additional, McAdams, H. Page, additional, Washington, Lacey, additional, McEvoy, Charlene, additional, Tashjian, Joseph, additional, Wise, Robert, additional, Brown, Robert, additional, Hansel, Nadia N., additional, Horton, Karen, additional, Lambert, Allison, additional, Putcha, Nirupama, additional, Casaburi, Richard, additional, Adami, Alessandra, additional, Budoff, Matthew, additional, Fischer, Hans, additional, Porszasz, Janos, additional, Rossiter, Harry, additional, Stringer, William, additional, Sharafkhaneh, Amir, additional, Lan, Charlie, additional, Wendt, Christine, additional, Bell, Brian, additional, Kunisaki, Ken M., additional, Flenaugh, Eric L., additional, Gebrekristos, Hirut, additional, Ponce, Mario, additional, Terpenning, Silanath, additional, Westney, Gloria, additional, Bowler, Russell, additional, Rosiello, Richard, additional, Pace, David, additional, Criner, Gerard, additional, Ciccolella, David, additional, Cordova, Francis, additional, Dass, Chandra, additional, D’Alonzo, Gilbert, additional, Desai, Parag, additional, Jacobs, Michael, additional, Kelsen, Steven, additional, Mamary, A. James, additional, Marchetti, Nathaniel, additional, Satti, Aditi, additional, Shenoy, Kartik, additional, Steiner, Robert M., additional, Swift, Alex, additional, Swift, Irene, additional, Vega-Sanchez, Maria Elena, additional, Dransfield, Mark, additional, Bailey, William, additional, Iyer, Anand, additional, Nath, Hrudaya, additional, Wells, J. Michael, additional, Conrad, Douglas, additional, Yen, Andrew, additional, Comellas, Alejandro P., additional, Newell, John, additional, Thompson, Brad, additional, Kazerooni, Ella, additional, Labaki, Wassim, additional, Galban, Craig, additional, Vummidi, Dharshan, additional, Billings, Joanne, additional, Begnaud, Abbie, additional, Allen, Tadashi, additional, Sciurba, Frank, additional, Chandra, Divay, additional, Weissfeld, Joel, additional, Anzueto, Antonio, additional, Adams, Sandra, additional, Maselli-Caceres, Diego, additional, Ruiz, Mario E., additional, and Singh, Harjinder, additional

Published
2023
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34. Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression

Author

Boueiz, Adel, Chang, Yale, Cho, Michael H., Washko, George R., José Estépar, Raul San, Bowler, Russell P., Crapo, James D., DeMeo, Dawn L., Dy, Jennifer G., Silverman, Edwin K., Castaldi, Peter J., Crapo, James, Silverman, Edwin, Make, Barry, Regan, Elizabeth, Beaty, Terri, Laird, Nan, Lange, Christoph, Cho, Michael H., Santorico, Stephanie, Hokanson, John, DeMeo, Dawn, Hansel, Nadia, Hersh, Craig, Castaldi, Peter, McDonald, Merry-Lynn, Wan, Emily, Hardin, Megan, Hetmanski, Jacqueline, Parker, Margaret, Foreman, Marilyn, Hobbs, Brian, Busch, Robert, Qiao, Dandi, Regan, Elizabeth, Halper-Stromberg, Eitan, Begum, Ferdouse, Won, Sungho, Lutz, Sharon, Lynch, David A., Coxson, Harvey O., Han, MeiLan K., Hoffman, Eric A., Humphries, Stephen, Jacobson, Francine L., Judy, Philip F., Kazerooni, Ella A., Newell, John D., Jr., Ross, James C., Estépar, Raul José, Stoel, Berend C., Tschirren, Juerg, Rikxoort, Eva van, van Ginneken, Bram, Wilson, Carla G., Qaisi, Mustafa Al, Gray, Teresa, Kluiber, Alex, Mann, Tanya, Sieren, Jered, Stinson, Douglas, Schroeder, Joyce, Beek, Edwin Van, Jensen, Robert, Everett, Douglas, Faino, Anna, Strand, Matt, Wilson, Carla, Hokanson, John E., Kinney, Gregory, Young, Kendra, Pratte, Katherine, Duca, Lindsey, Curtis, Jeffrey L., Martinez, Carlos H., Pernicano, Perry G., Hanania, Nicola, Alapat, Philip, Bandi, Venkata, Atik, Mustafa, Boriek, Aladin, Guntupalli, Kalpatha, Guy, Elizabeth, Parulekar, Amit, Nachiappan, Arun, Jacobson, Francine, Barr, Graham R., Thomashow, Byron, Austin, John, D’Souza, Belinda, Pearson, Gregory D.N., Rozenshtein, Anna, MacIntyre, Neil, Jr., Washington, Lacey, McAdams, Page H., McEvoy, Charlene, Tashjian, Joseph, Wise, Robert, Brown, Robert, Horton, Karen, Putcha, Nirupama, Casaburi, Richard, Adami, Alessandra, Porszasz, Janos, Fischer, Hans, Budoff, Matthew, Rossiter, Harry, Sharafkhaneh, Amir, Lan, Charlie, Wendt, Christine, Bell, Brian, Foreman, Marilyn, Westney, Gloria, Berkowitz, Eugene, Bowler, Russell, Lynch, David, Rosiello, Richard, Pace, David, Criner, Gerard, Ciccolella, David, Cordova, Francis, Dass, Chandra, D’Alonzo, Gilbert, Desai, Parag, Jacobs, Michael, Kelsen, Steven, Kim, Victor, Mamary, James A., Marchetti, Nathaniel, Satti, Aditi, Shenoy, Kartik, Steiner, Robert M., Swift, Alex, Swift, Irene, Vega-Sanchez, Maria Elena, Dransfield, Mark, Bailey, William, Wells, Michael J., Bhatt, Surya, Nath, Hrudaya, Ramsdell, Joe, Friedman, Paul, Soler, Xavier, Yen, Andrew, Cornellas, Alejandro, Newell, John, Jr., Thompson, Brad, Han, MeiLan, Kazerooni, Ella, Martinez, Carlos, Billings, Joanne, Allen, Tadashi, Sciurba, Frank, Chandra, Divay, Weissfeld, Joel, Fuhrman, Carl, Bon, Jessica, Anzueto, Antonio, Adams, Sandra, Maselli-Caceres, Diego, and Ruiz, Mario E.

Published
2018
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37. Longitudinal Association Between Muscle Loss and Mortality in Ever Smokers

Author

Mason, Stefanie E., primary, Moreta-Martinez, Rafael, additional, Labaki, Wassim W., additional, Strand, Matthew J., additional, Regan, Elizabeth A., additional, Bon, Jessica, additional, San Jose Estepar, Ruben, additional, Casaburi, Richard, additional, McDonald, Merry-Lynn, additional, Rossiter, Harry B., additional, Make, Barry, additional, Dransfield, Mark T., additional, Han, MeiLan K., additional, Young, Kendra, additional, Curtis, Jeffrey L., additional, Stringer, Kathleen, additional, Kinney, Greg, additional, Hokanson, John E., additional, San Jose Estepar, Raul, additional, Washko, George R., additional, Crapo, James D., additional, Silverman, Edwin K., additional, Cummings, Sara, additional, Madden, Kelley, additional, Make, Barry J., additional, Nabbosa, Juliet, additional, Port, Emily, additional, Rashdi, Serine, additional, Stepp, Lori, additional, Watts, Shandi, additional, Weaver, Michael, additional, Beaty, Terri, additional, Bowler, Russell P., additional, Lynch, David A., additional, Anderson, Gary, additional, Bleecker, Eugene R., additional, Coxson, Harvey O., additional, Crystal, Ronald G., additional, Hogg, James C., additional, Province, Michael A., additional, Rennard, Stephen I., additional, Croxton, Thomas, additional, Gan, Weiniu, additional, Postow, Lisa A., additional, Viviano, Lisa M., additional, Costa-Davis, Corinne, additional, Malanga, Elisha, additional, Prieto, Delia, additional, Tal-Singer, Ruth, additional, Farzadegan, Homayoon, additional, Hadji, Akila, additional, Sathe, Leena, additional, Baraghoshi, David, additional, Chen, Grace, additional, Crooks, James, additional, Knowles, Ruthie, additional, Pratte, Katherine, additional, Wilson, Carla, additional, Zelarney, Pearlanne T., additional, Kechris, Katerina J., additional, Leach, Sonia, additional, Austin, Erin E., additional, Czizik, Annika, additional, Kinney, Gregory, additional, Li, Yisha, additional, Lutz, Sharon M., additional, Ragland, Margaret F., additional, Richmond, Nicole, additional, Young, Kendra A., additional, Cho, Michael, additional, Castaldi, Peter J., additional, Glass, Kimberly, additional, Hersh, Craig, additional, Kim, Wonji, additional, Liu, Yang-Yu, additional, Hersh, Craig P., additional, Bidinger, Jacqueline, additional, Cho, Michael H., additional, Conrad, Douglas, additional, DeMeo, Dawn L., additional, El-Boueiz, Adel R., additional, Foreman, Marilyn G., additional, Ghosh, Auyon, additional, Hahn, Georg, additional, Hansel, Nadia N., additional, Hayden, Lystra P., additional, Hobbs, Brian, additional, Kim, Woori, additional, Lange, Christoph, additional, McDonald, Merry- Lynn, additional, McGeachie, Michael, additional, Moll, Matthew, additional, Morris, Melody, additional, Patsopoulos, Nikolaos A., additional, Qiao, Dandi, additional, Ruczinski, Ingo, additional, Wan, Emily S., additional, Dy, Jennifer G., additional, Fain, Sean B., additional, Ginsburg, Shoshana, additional, Hoffman, Eric A., additional, Humphries, Stephen, additional, Judy, Philip F., additional, Stefanie Mason, Alex Kluiber, additional, Oh, Andrea, additional, Poynton, Clare, additional, Reinhardt, Joseph M., additional, Ross, James, additional, Schroeder, Joyce D., additional, Sitek, Arkadiusz, additional, Steiner, Robert M., additional, van Beek, Edwin, additional, Ginneken, Bram van, additional, van Rikxoort, Eva, additional, Jensen, Robert, additional, John E. Hokanson, Co-Chair:, additional, Bhatt, Surya P., additional, Kim, Victor, additional, Putcha, Nirupama, additional, Han, MeiLan, additional, Diaz, Alejandro A., additional, Regan, Elizabeth, additional, Anzueto, Antonio, additional, Bailey, William C., additional, Criner, Gerard J., additional, Sprenger, Kim, additional, Benos, Takis, additional, Hanania, Nicola A., additional, Hoth, Karin F., additional, Lambert, Allison, additional, Lowe, Katherine, additional, Oates, Gabriela, additional, Parekh, Trisha, additional, Westney, Gloria, additional, Balasubramanian, Aparna, additional, Boriek, Aladin, additional, Fawzy, Ashraf, additional, Jacobson, Francine, additional, LaFon, David C., additional, MacIntyre, Neil, additional, Maselli-Caceres, Diego, additional, McCormack, Meredith C., additional, Sciurba, Frank, additional, Soler, Xavier, additional, Tejwani, Vickram, additional, van Beek, Edwin JR., additional, Wade, Raymond C., additional, Wells, Mike, additional, Wendt, Chris H., additional, Yun, Jeong H., additional, Zhang, Jingzhou, additional, Gillenwater, Lucas, additional, Lowe, Katherine E., additional, Pratte, Katherine A., additional, Ragland, Margaret, additional, Attaway, Amy, additional, Mason, Stefanie, additional, Saha, Punam Kumar, additional, Wilson, Ava, additional, Amaza, Hannatu, additional, Baldomero, Adrienne, additional, Mamary, A. James, additional, O’Brien, James, additional, Wise, Robert A., additional, Eakin, Michelle, additional, Fiedorowicz, Jess G., additional, Henkle, Ben, additional, Holm, Kristen, additional, Iyer, Anand, additional, Kunisaki, Ken M., additional, McEvoy, Charlene, additional, Mkorombindo, Takudzwa, additional, Shinozaki, Gen, additional, Yohannes, Abebaw, additional, Hobbs, Brian D., additional, Miller, Bruce E., additional, Retson, Tara, additional, McCloskey, Lisa, additional, Pernicano, Perry G., additional, Atik, Mustafa, additional, Bertrand, Laura, additional, Monaco, Thomas, additional, Narendra, Dharani, additional, Lenge de Rosen, Veronica V., additional, Badu-Danso, Kwame, additional, Jacobson, Francine L., additional, Kaufman, Laura, additional, Maguire, Cherie, additional, Struble, Sophie, additional, Wilson, Seth, additional, Barr, R. Graham, additional, Almonte, Casandra, additional, Austin, John H.M., additional, Gomez Blum, Maria Lorena, additional, D’Souza, Belinda M., additional, Florez, Emilay, additional, Martinez, Rodney, additional, Curry, Wendy, additional, McAdams, H. Page, additional, Reikofski, Charlotte V., additional, Washington, Lacey, additional, Brown, Robert, additional, Clare, Cheryl, additional, Daniel, Marie, additional, Horton, Karen, additional, Ting “Tony” Lin, Cheng, additional, Mirza, Tahira, additional, Scott, Meagan, additional, Shade, Becky, additional, Budoff, Matt, additional, Calmelat, Robert, additional, Cavanaugh, Deborah, additional, Dailing, Chris, additional, Diaz, Leticia, additional, Fischer, Hans, additional, Indelicato, Renee Love, additional, Porszasz, Janos, additional, Soriano, April, additional, Stringer, William, additional, Urrutia, Miriam, additional, Baldomero, Arianne, additional, Bell, Brian, additional, Deconcini, Miranda, additional, Loes, Linda, additional, Phelan, Jonathan, additional, Robichaux, Camille, additional, Sasse, Cheryl, additional, Tashjian, Joseph H., additional, Flenaugh, Eric L., additional, Abson, Kema, additional, Gebrekristos, Hirut, additional, Johnson, Priscilla, additional, Jordan, Jessica, additional, Ponce, Mario, additional, Terpenning, Silanath, additional, Wilson, Derrick, additional, Broadhurst, Grace, additional, Dyer, Debra, additional, Engel, Elena, additional, Finigan, Jay, additional, Hill, Andrew, additional, Jones, Alex, additional, Jones, Ryan, additional, Owen, Jordan, additional, Rosiello, Richard, additional, Andries, Nicole, additional, Charpentier, Mary, additional, Kirk, Diane, additional, Pace, David, additional, Ciccolella, David, additional, Cordova, Francis, additional, Dass, Chandra, additional, D’Alonzo, Gilbert, additional, Davis, Valena, additional, Desai, Parag, additional, Fehrle, Dee, additional, Grabianowski, Carla, additional, Jacobs, Michael, additional, Jameson, Laurie, additional, Jones, Gayle M., additional, Kelsen, Steven, additional, Marchetti, Nathaniel, additional, McGonagle, Francine, additional, Satti, Aditi, additional, Shenoy, Kartik, additional, Sheridan, Regina, additional, Vega-Sanchez, Maria, additional, Wallace, Samantha, additional, Akinseye-kolapo, Samuel, additional, Baker, Matthew, additional, Goggins, Arnissa, additional, McClain, Anny, additional, Nath, Hrudaya, additional, Singh, Satinder P., additional, Sonavane, Sushil K., additional, Westfall, Elizabeth, additional, Gil, Marissa, additional, El Hajjaoui, Tarek, additional, Hsiao, Albert, additional, Martineau, Amber, additional, Mielke, Jenna, additional, Perez, Karl, additional, Querido, Gabriel, additional, Reston, Tara, additional, Yen, Andrew, additional, Comellas, Alejandro, additional, Fortis, Spyridon, additional, Galizia, Mauricio, additional, Garcia, Eric, additional, Keating, Janet, additional, Laroia, Archana, additional, Lee, Changhyun, additional, Meyer, Amber, additional, Mullan, Brian, additional, Nagpal, Prashant, additional, Ofori, Oloigbe, additional, and Suiter, Sierra, additional

Published
2022
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38. Quantitative Interstitial Abnormality Progression and Outcomes in the COPDGene and PLuSS Cohorts

Author

Bina, Choi, Najma, Adan, Tracy J, Doyle, Ruben, San José Estépar, Rola, Harmouche, Stephen M, Humphries, Matthew, Moll, Michael H, Cho, Rachel K, Putman, Gary M, Hunninghake, Ravi, Kalhan, Gabrielle Y, Liu, Alejandro A, Diaz, Stefanie E, Mason, Farbod N, Rahaghi, Carrie L, Pistenmaa, Nicholas, Enzer, Clare, Poynton, Gonzalo Vegas, Sánchez-Ferrero, James C, Ross, David A, Lynch, Fernando J, Martinez, MeiLan K, Han, Russell P, Bowler, David O, Wilson, Ivan O, Rosas, George R, Washko, Raúl, San José Estépar, and Samuel Y, Ash

Abstract

The risk factors and clinical outcomes of quantitative interstitial abnormality progression over time have not been characterized.What are the associations of quantitative interstitial abnormality progression with lung function, exercise capacity, and mortality? What are the demographic and genetic risk factors for quantitative interstitial abnormality progression?Quantitative interstitial abnormality progression between visits 1 and 2 was assessed from 4,635 participants in the Genetic Epidemiology of COPD (COPDGene) cohort and 1,307 participants in the Pittsburgh Lung Screening Study (PLuSS) cohort. We used multivariable linear regression to determine the risk factors for progression and the longitudinal associations between progression and FVC and 6-min walk distance, and Cox regression models for the association with mortality.Age at enrollment, female sex, current smoking status, and the MUC5B minor allele were associated with quantitative interstitial abnormality progression. Each percent annual increase in quantitative interstitial abnormalities was associated with annual declines in FVC (COPDGene: 8.5 mL/y; 95% CI, 4.7-12.4 mL/y; P .001; PLuSS: 9.5 mL/y; 95% CI, 3.7-15.4 mL/y; P = .001) and 6-min walk distance, and increased mortality (COPDGene: hazard ratio, 1.69; 95% CI, 1.34-2.12; P .001; PLuSS: hazard ratio, 1.28; 95% CI, 1.10-1.49; P = .001).The objective, longitudinal measurement of quantitative interstitial abnormalities may help identify people at greatest risk for adverse events and most likely to benefit from early intervention.

Published
2022

40. Detection and Early Referral of Patients With Interstitial Lung Abnormalities

Author

Hunninghake, Gary M., primary, Goldin, Jonathan G., additional, Kadoch, Michael A., additional, Kropski, Jonathan A., additional, Rosas, Ivan O., additional, Wells, Athol U., additional, Yadav, Ruchi, additional, Lazarus, Howard M., additional, Abtin, Fereidoun G., additional, Corte, Tamera J., additional, de Andrade, Joao A., additional, Johannson, Kerri A., additional, Kolb, Martin R., additional, Lynch, David A., additional, Oldham, Justin M., additional, Spagnolo, Paolo, additional, Strek, Mary E., additional, Tomassetti, Sara, additional, Washko, George R., additional, White, Eric S., additional, Abtin, Fereidoun, additional, Antoniou, Katerina, additional, Blackwell, Timothy, additional, Brown, Kevin, additional, Chung, Jonathan, additional, Corte, Tamera, additional, Crestani, Bruno, additional, Crossno, Peter, additional, Culver, Daniel, additional, de Andrade, Joao, additional, Deveraj, Anand, additional, Flaherty, Kevin, additional, Gudmundsson, Gunnar, additional, Hatabu, Hiroto, additional, Jacob, Joe, additional, Johansson, Kerri, additional, Kanne, Jeff, additional, Kazerooni, Ella, additional, Kolb, Martin, additional, Lynch, David, additional, Maher, Toby, additional, Martinez, Fernando, additional, Morais, Antonio, additional, Nathan, Steven D., additional, Noth, Imre, additional, Oldham, Justin, additional, Podolanczuk, Anna, additional, Poletti, Venerino, additional, Ravaglia, Claudia, additional, Renzoni, Elizabetta, additional, Richeldi, Luca, additional, Rubin, Geoffrey, additional, Ryerson, Chris, additional, Sahoo, Debasis, additional, Suh, Rob, additional, Sverzellati, Nicola, additional, Valeyre, Dominique, additional, Walsh, Simon, additional, and Washko, George, additional

Published
2022
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41. Longitudinal Association Between Muscle Loss and Mortality in Ever Smokers

Author

Stefanie E. Mason, Rafael Moreta-Martinez, Wassim W. Labaki, Matthew J. Strand, Elizabeth A. Regan, Jessica Bon, Ruben San Jose Estepar, Richard Casaburi, Merry-Lynn McDonald, Harry B. Rossiter, Barry Make, Mark T. Dransfield, MeiLan K. Han, Kendra Young, Jeffrey L. Curtis, Kathleen Stringer, Greg Kinney, John E. Hokanson, Raul San Jose Estepar, George R. Washko, James D. Crapo, Edwin K. Silverman, Sara Cummings, Kelley Madden, Barry J. Make, Juliet Nabbosa, Emily Port, Serine Rashdi, Lori Stepp, Shandi Watts, Michael Weaver, Terri Beaty, Russell P. Bowler, David A. Lynch, Gary Anderson, Eugene R. Bleecker, Harvey O. Coxson, Ronald G. Crystal, James C. Hogg, Michael A. Province, Stephen I. Rennard, Thomas Croxton, Weiniu Gan, Lisa A. Postow, Lisa M. Viviano, Corinne Costa-Davis, Elisha Malanga, Delia Prieto, Ruth Tal-Singer, Homayoon Farzadegan, Akila Hadji, Leena Sathe, David Baraghoshi, Grace Chen, James Crooks, Ruthie Knowles, Katherine Pratte, Carla Wilson, Pearlanne T. Zelarney, Katerina J. Kechris, Sonia Leach, Erin E. Austin, Annika Czizik, Gregory Kinney, Yisha Li, Sharon M. Lutz, Margaret F. Ragland, Nicole Richmond, Kendra A. Young, Michael Cho, Peter J. Castaldi, Kimberly Glass, Craig Hersh, Wonji Kim, Yang-Yu Liu, Craig P. Hersh, Jacqueline Bidinger, Michael H. Cho, Douglas Conrad, Dawn L. DeMeo, Adel R. El-Boueiz, Marilyn G. Foreman, Auyon Ghosh, Georg Hahn, Nadia N. Hansel, Lystra P. Hayden, Brian Hobbs, Woori Kim, Christoph Lange, Merry- Lynn McDonald, Michael McGeachie, Matthew Moll, Melody Morris, Nikolaos A. Patsopoulos, Dandi Qiao, Ingo Ruczinski, Emily S. Wan, Jennifer G. Dy, Sean B. Fain, Shoshana Ginsburg, Eric A. Hoffman, Stephen Humphries, Philip F. Judy, Alex Kluiber Stefanie Mason, Andrea Oh, Clare Poynton, Joseph M. Reinhardt, James Ross, Joyce D. Schroeder, Arkadiusz Sitek, Robert M. Steiner, Edwin van Beek, Bram van Ginneken, Eva van Rikxoort, Robert Jensen, Co-Chair: John E. Hokanson, Surya P. Bhatt, Victor Kim, Nirupama Putcha, MeiLan Han, Alejandro A. Diaz, Elizabeth Regan, Antonio Anzueto, William C. Bailey, Gerard J. Criner, Kim Sprenger, Takis Benos, Nicola A. Hanania, Karin F. Hoth, Allison Lambert, Katherine Lowe, Gabriela Oates, Trisha Parekh, Gloria Westney, Aparna Balasubramanian, Aladin Boriek, Ashraf Fawzy, Francine Jacobson, David C. LaFon, Neil MacIntyre, Diego Maselli-Caceres, Meredith C. McCormack, Frank Sciurba, Xavier Soler, Vickram Tejwani, Edwin JR. van Beek, Raymond C. Wade, Mike Wells, Chris H. Wendt, Jeong H. Yun, Jingzhou Zhang, Lucas Gillenwater, Katherine E. Lowe, Katherine A. Pratte, Margaret Ragland, Amy Attaway, Stefanie Mason, Punam Kumar Saha, Ava Wilson, Hannatu Amaza, Adrienne Baldomero, A. James Mamary, James O’Brien, Robert A. Wise, Michelle Eakin, Jess G. Fiedorowicz, Ben Henkle, Kristen Holm, Anand Iyer, Ken M. Kunisaki, Charlene McEvoy, Takudzwa Mkorombindo, Gen Shinozaki, Abebaw Yohannes, Brian D. Hobbs, Bruce E. Miller, Tara Retson, Lisa McCloskey, Perry G. Pernicano, Mustafa Atik, Laura Bertrand, Thomas Monaco, Dharani Narendra, Veronica V. Lenge de Rosen, Kwame Badu-Danso, Francine L. Jacobson, Laura Kaufman, Cherie Maguire, Sophie Struble, Seth Wilson, R. Graham Barr, Casandra Almonte, John H.M. Austin, Maria Lorena Gomez Blum, Belinda M. D’Souza, Emilay Florez, Rodney Martinez, Wendy Curry, H. Page McAdams, Charlotte V. Reikofski, Lacey Washington, Robert Brown, Cheryl Clare, Marie Daniel, Karen Horton, Cheng Ting 'Tony' Lin, Tahira Mirza, Meagan Scott, Becky Shade, Matt Budoff, Robert Calmelat, Deborah Cavanaugh, Chris Dailing, Leticia Diaz, Hans Fischer, Renee Love Indelicato, Janos Porszasz, April Soriano, William Stringer, Miriam Urrutia, Arianne Baldomero, Brian Bell, Miranda Deconcini, Linda Loes, Jonathan Phelan, Camille Robichaux, Cheryl Sasse, Joseph H. Tashjian, Eric L. Flenaugh, Kema Abson, Hirut Gebrekristos, Priscilla Johnson, Jessica Jordan, Mario Ponce, Silanath Terpenning, Derrick Wilson, Grace Broadhurst, Debra Dyer, Elena Engel, Jay Finigan, Andrew Hill, Alex Jones, Ryan Jones, Jordan Owen, Richard Rosiello, Nicole Andries, Mary Charpentier, Diane Kirk, David Pace, David Ciccolella, Francis Cordova, Chandra Dass, Gilbert D’Alonzo, Valena Davis, Parag Desai, Dee Fehrle, Carla Grabianowski, Michael Jacobs, Laurie Jameson, Gayle M. Jones, Steven Kelsen, Nathaniel Marchetti, Francine McGonagle, Aditi Satti, Kartik Shenoy, Regina Sheridan, Maria Vega-Sanchez, Samantha Wallace, Samuel Akinseye-kolapo, Matthew Baker, Arnissa Goggins, Anny McClain, Hrudaya Nath, Satinder P. Singh, Sushil K. Sonavane, Elizabeth Westfall, Marissa Gil, Tarek El Hajjaoui, Albert Hsiao, Amber Martineau, Jenna Mielke, Karl Perez, Gabriel Querido, Tara Reston, Andrew Yen, Alejandro Comellas, Spyridon Fortis, Mauricio Galizia, Eric Garcia, Janet Keating, Archana Laroia, Changhyun Lee, Amber Meyer, Brian Mullan, Prashant Nagpal, Oloigbe Ofori, and Sierra Suiter

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Chronic Obstructive, Clinical Sciences, Respiratory System, Critical Care and Intensive Care Medicine, COPD: Original Research, Body Mass Index, Pectoralis Muscles, Pulmonary Disease, sarcopenia, Pulmonary Disease, Chronic Obstructive, Interquartile range, Clinical Research, Internal medicine, medicine, Tobacco Smoking, COPD, 2.1 Biological and endogenous factors, Humans, Longitudinal Studies, Aetiology, Pectoralis Muscle, Lung, Nutrition, Smokers, COPDGene Investigators, Proportional hazards model, business.industry, Prevention, Smoking, muscle wasting, medicine.disease, mortality, Confidence interval, Good Health and Well Being, Sarcopenia, Cardiology, Body Composition, Cardiology and Cardiovascular Medicine, business, Body mass index, Bioelectrical impedance analysis, Biomarkers
Abstract

BackgroundBody composition measures, specifically low weight or reduced muscle mass, are associated with mortality in COPD, but the effect of longitudinal body composition changes is undefined.Research questionIs the longitudinal loss of fat-free mass (FFM) associated with increased mortality, including in those with initially normal or elevated body composition metrics?Study design and methodsParticipants with complete data for at least one visit in the COPDGene study (n= 9,268) and the ECLIPSE study (n= 1,760) were included and monitored for 12 and 8 years, respectively. Pectoralis muscle area (PMA) was derived from thoracic CT scans and used as a proxy for FFM. A longitudinal mixed submodel for PMA and a Cox proportional hazards submodel for survival were fitted on a joint distribution, using a shared random intercept parameter and Markov chain Monte Carlo parameter estimation.ResultsBoth cohorts demonstrated a left-shifted distribution of baseline FFM, not reflected in BMI, and an increase in all-cause mortality risk associated with longitudinal loss of PMA. For each 1-cm2 PMA loss, mortality increased 3.1%(95%CI, 2.4%-3.7%; P< .001) in COPDGene, and 2.4%(95%CI, 0.9%-4.0%; P< .001) in ECLIPSE. Increased mortality risk was independent of enrollment values for BMI and disease severity [BODE (body mass, airflow obstruction, dyspnea, and exercise capacity) index quartiles] and was significant even in participants with initially greater than average PMA.InterpretationLongitudinal loss of PMA is associated with increased all-cause mortality, regardless of BMI or initial muscle mass. Consideration of novel screening tests and further research into mechanisms contributing to muscle decline may improve risk stratification and identify novel therapeutic targets in ever smokers.

Published
2021

42. Emphysema Progression and Lung Function Decline Among Angiotensin Converting Enzyme Inhibitors and Angiotensin-Receptor Blockade Users in the COPDGene Cohort

Author

Tejwani, Vickram, primary, Fawzy, Ashraf, additional, Putcha, Nirupama, additional, Castaldi, Peter J., additional, Cho, Michael H., additional, Pratte, Katherine A., additional, Bhatt, Surya P., additional, Lynch, David A., additional, Humphries, Stephen M., additional, Kinney, Gregory L., additional, D’Alessio, Franco R., additional, Hansel, Nadia N., additional, Crapo, James D., additional, Silverman, Edwin K., additional, Make, Barry J., additional, Regan, Elizabeth A., additional, Beaty, Terri, additional, Begum, Ferdouse, additional, Cho, Michael, additional, DeMeo, Dawn L., additional, Boueiz, Adel R., additional, Foreman, Marilyn G., additional, Halper-Stromberg, Eitan, additional, Hayden, Lystra P., additional, Hersh, Craig P., additional, Hetmanski, Jacqueline, additional, Hobbs, Brian D., additional, Hokanson, John E., additional, Laird, Nan, additional, Lange, Christoph, additional, Lutz, Sharon M., additional, McDonald, Merry-Lynn, additional, Parker, Margaret M., additional, Prokopenko, Dmitry, additional, Qiao, Dandi, additional, Sakornsakolpat, Phuwanat, additional, Wan, Emily S., additional, Won, Sungho, additional, Centeno, Juan Pablo, additional, Charbonnier, Jean-Paul, additional, Coxson, Harvey O., additional, Galban, Craig J., additional, Han, MeiLan K., additional, Hoffman, Eric A., additional, Humphries, Stephen, additional, Jacobson, Francine L., additional, Judy, Philip F., additional, Kazerooni, Ella A., additional, Kluiber, Alex, additional, Nardelli, Pietro, additional, Newell, John D., additional, Notary, Aleena, additional, Oh, Andrea, additional, Ross, James C., additional, San Jose Estepar, Raul, additional, Schroeder, Joyce, additional, Sieren, Jered, additional, Stoel, Berend C., additional, Tschirren, Juerg, additional, Van Beek, Edwin, additional, Ginneken, Bramvan, additional, van Rikxoort, Eva, additional, Sanchez-Ferrero, Gonzalo Vegas, additional, Veitel, Lucas, additional, Washko, George R., additional, Wilson, Carla G., additional, Jensen, Robert, additional, Everett, Douglas, additional, Crooks, Jim, additional, Pratte, Katherine, additional, Strand, Matt, additional, Kinney, Gregory, additional, Young, Kendra A., additional, Bon, Jessica, additional, Diaz, Alejandro A., additional, Make, Barry, additional, Murray, Susan, additional, Regan, Elizabeth, additional, Soler, Xavier, additional, Bowler, Russell P., additional, Kechris, Katerina, additional, Banaei-Kashani, Farnoush, additional, Curtis, Jeffrey L., additional, Pernicano, Perry G., additional, Hanania, Nicola, additional, Atik, Mustafa, additional, Boriek, Aladin, additional, Guntupalli, Kalpatha, additional, Guy, Elizabeth, additional, Parulekar, Amit, additional, Hersh, Craig, additional, Washko, George, additional, Barr, R. Graham, additional, Austin, John, additional, D’Souza, Belinda, additional, Thomashow, Byron, additional, MacIntyre, Neil, additional, McAdams, H. Page, additional, Washington, Lacey, additional, Flenaugh, Eric, additional, Terpenning, Silanth, additional, McEvoy, Charlene, additional, Tashjian, Joseph, additional, Wise, Robert, additional, Brown, Robert, additional, Horton, Karen, additional, Lambert, Allison, additional, Casaburi, Richard, additional, Adami, Alessandra, additional, Budoff, Matthew, additional, Fischer, Hans, additional, Porszasz, Janos, additional, Rossiter, Harry, additional, Stringer, William, additional, Sharafkhaneh, Amir, additional, Lan, Charlie, additional, Wendt, Christine, additional, Bell, Brian, additional, Kunisaki, KenM., additional, Bowler, Russell, additional, Rosiello, Richard, additional, Pace, David, additional, Criner, Gerard, additional, Ciccolella, David, additional, Cordova, Francis, additional, Dass, Chandra, additional, D’Alonzo, Gilbert, additional, Desai, Parag, additional, Jacobs, Michael, additional, Kelsen, Steven, additional, Kim, Victor, additional, Mamary, A. James, additional, Marchetti, Nathaniel, additional, Satti, Aditi, additional, Shenoy, Kartik, additional, Steiner, Robert M., additional, Swift, Alex, additional, Swift, Irene, additional, Vega-Sanchez, Maria Elena, additional, Dransfield, Mark, additional, Bailey, William, additional, Iyer, Anand, additional, Nath, Hrudaya, additional, Wells, J. Michael, additional, Conrad, Douglas, additional, Yen, Andrew, additional, Comellas, Alejandro P., additional, Hoth, Karin F., additional, Newell, John, additional, Thompson, Brad, additional, Kazerooni, Ella, additional, Labaki, Wassim, additional, Galban, Craig, additional, Vummidi, Dharshan, additional, Billings, Joanne, additional, Begnaud, Abbie, additional, Allen, Tadashi, additional, Sciurba, Frank, additional, Chandra, Divay, additional, Fuhrman, Carl, additional, and Weissfeld, Joel, additional

Published
2021
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44. CT MEASURES OF INTRAPARENCHYMAL VASCULAR VOLUME IN COPD PATIENTS WITH AND WITHOUT PULMONARY HYPERTENSION

Author

Imama Ahmad, George R. Washko, Farbod N. Rahaghi, Ruben San Jose Estepar, Sneha Lakshman, Pietro Nardelli, and Raúl San José Estépar

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, Copd patients, Internal medicine, medicine, Cardiology, Vascular volume, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, business, medicine.disease, Pulmonary hypertension
Published
2021
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45. QUANTITATIVE COMPUTER TOMOGRAPHY MEASURES OF BODY COMPOSITION AND THE ASSOCIATION WITH MORTALITY, ALL CAUSE, COPD AND PNEUMONIA RELATED HOSPITAL ADMISSION IN A LARGE LUNG CANCER SCREENING COHORT

Author

Alissa Ali, Brady McKee, Will Thedinger, Giulia S. Rizzo, Raúl San José Estépar, Kimberly M. Rieger-Christ, Timothy Liesching, Cristina F. Stefanescu, Andrea B. McKee, Lori Lyn Price, Elizabeth J. Pagura, Carla Lamb, Ava Sanayei, Christoph Wald, William J. Long, George R. Washko, Shawn Regis, and Lee Gazourian

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, COPD, business.industry, Critical Care and Intensive Care Medicine, medicine.disease, Pneumonia, Internal medicine, Cohort, Hospital admission, medicine, Cardiology and Cardiovascular Medicine, business, All cause mortality, Lung cancer screening
Published
2021
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46. Pulmonary Arterial Pruning and Longitudinal Change in Percent Emphysema and Lung Function

Author

Pistenmaa, Carrie L., primary, Nardelli, P., additional, Ash, S.Y., additional, Come, C.E., additional, Diaz, A.A., additional, Rahaghi, F.N., additional, Barr, R.G., additional, Young, K.A., additional, Kinney, G.L., additional, Simmons, J.P., additional, Wade, R.C., additional, Wells, J.M., additional, Hokanson, J.E., additional, Washko, G.R., additional, San José Estépar, R., additional, Crapo, James D., additional, Silverman, Edwin K., additional, Make, Barry J., additional, Regan, Elizabeth A., additional, Beaty, Terri H., additional, Castaldi, Peter J., additional, Cho, Michael H., additional, DeMeo, Dawn L., additional, El Boueiz, Adel, additional, Foreman, Marilyn G., additional, Ghosh, Auyon, additional, Hayden, Lystra P., additional, Hersh, Craig P., additional, Hetmanski, Jacqueline, additional, Hobbs, Brian D., additional, Hokanson, John E., additional, Kim, Wonji, additional, Laird, Nan, additional, Lange, Christoph, additional, Lutz, Sharon M., additional, McDonald, Merry-Lynn, additional, Prokopenko, Dmitry, additional, Moll, Matthew, additional, Morrow, Jarrett, additional, Qiao, Dandi, additional, Saferali, Aabida, additional, Sakornsakolpat, Phuwanat, additional, Wan, Emily S., additional, Yun, Jeong, additional, Centeno, Juan Pablo, additional, Charbonnier, Jean-Paul, additional, Coxson, Harvey O., additional, Galban, Craig J., additional, Han, MeiLan K., additional, Hoffman, Eric A., additional, Humphries, Stephen, additional, Jacobson, Francine L., additional, Judy, Philip F., additional, Kazerooni, Ella A., additional, Kluiber, Alex, additional, Lynch, David A., additional, Nardelli, Pietro, additional, Newell, John D., additional, Notary, Aleena, additional, Oh, Andrea, additional, Ross, James C., additional, San Jose Estepar, Raul, additional, Schroeder, Joyce, additional, Sieren, Jered, additional, Stoel, Berend C., additional, Tschirren, Juerg, additional, Van Beek, Edwin, additional, Ginneken, Bramvan, additional, van Rikxoort, Eva, additional, Sanchez- Ferrero, Gonzalo Vegas, additional, Veitel, Lucas, additional, Washko, George R., additional, Wilson, Carla G., additional, Jensen, Robert, additional, Everett, Douglas, additional, Crooks, Jim, additional, Pratte, Katherine, additional, Strand, Matt, additional, Austin, Erin, additional, Kinney, Gregory, additional, Young, Kendra A., additional, Bhatt, Surya P., additional, Bon, Jessica, additional, Diaz, Alejandro A., additional, Make, Barry, additional, Murray, Susan, additional, Regan, Elizabeth, additional, Soler, Xavier, additional, Bowler, Russell P., additional, Kechris, Katerina, additional, Banaei-Kashani, Farnoush, additional, Curtis, Jeffrey L., additional, Pernicano, Perry G., additional, Hanania, Nicola, additional, Atik, Mustafa, additional, Boriek, Aladin, additional, Guntupalli, Kalpatha, additional, Guy, Elizabeth, additional, Parulekar, Amit, additional, Hersh, Craig, additional, Washko, George, additional, Barr, R. Graham, additional, Austin, John, additional, D’Souza, Belinda, additional, Thomashow, Byron, additional, MacIntyre, Neil, additional, McAdams, H. Page, additional, Washington, Lacey, additional, McEvoy, Charlene, additional, Tashjian, Joseph, additional, Wise, Robert, additional, Brown, Robert, additional, Hansel, Nadia N., additional, Horton, Karen, additional, Lambert, Allison, additional, Putcha, Nirupama, additional, Casaburi, Richard, additional, Adami, Alessandra, additional, Budoff, Matthew, additional, Fischer, Hans, additional, Porszasz, Janos, additional, Rossiter, Harry, additional, Stringer, William, additional, Sharafkhaneh, Amir, additional, Lan, Charlie, additional, Wendt, Christine, additional, Bell, Brian, additional, Kunisaki, Ken M., additional, Flenaugh, Eric L., additional, Gebrekristos, Hirut, additional, Ponce, Mario, additional, Terpenning, Silanath, additional, Westney, Gloria, additional, Bowler, Russell, additional, Rosiello, Richard, additional, Pace, David, additional, Criner, Gerard, additional, Ciccolella, David, additional, Cordova, Francis, additional, Dass, Chandra, additional, D’Alonzo, Gilbert, additional, Desai, Parag, additional, Jacobs, Michael, additional, Kelsen, Steven, additional, Kim, Victor, additional, Mamary, A. James, additional, Marchetti, Nathaniel, additional, Satti, Aditi, additional, Shenoy, Kartik, additional, Steiner, Robert M., additional, Swift, Alex, additional, Swift, Irene, additional, Vega-Sanchez, Maria Elena, additional, Dransfield, Mark, additional, Bailey, William, additional, Iyer, Anand, additional, Nath, Hrudaya, additional, Wells, J. Michael, additional, Conrad, Douglas, additional, Yen, Andrew, additional, Comellas, Alejandro P., additional, Hoth, Karin F., additional, Newell, John, additional, Thompson, Brad, additional, Kazerooni, Ella, additional, Labaki, Wassim, additional, Galban, Craig, additional, Vummidi, Dharshan, additional, Billings, Joanne, additional, Begnaud, Abbie, additional, Allen, Tadashi, additional, Sciurba, Frank, additional, Chandra, Divay, additional, and Weissfeld, Joel, additional

Published
2021
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47. An Integrative Genomic Strategy Identifies sRAGE as a Causal and Protective Biomarker of Lung Function

Author

Keefe, Joshua, primary, Yao, Chen, additional, Hwang, Shih-Jen, additional, Courchesne, Paul, additional, Lee, Gha Young, additional, Dupuis, Josée, additional, Mizgerd, Joseph P., additional, O’Connor, George, additional, Washko, George R., additional, Cho, Michael H., additional, Silverman, Edwin K., additional, and Levy, Daniel, additional

Published
2021
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48. Emphysema Progression and Lung Function Decline Among Angiotensin Converting Enzyme Inhibitors and Angiotensin-Receptor Blockade Users in the COPDGene Cohort

Author

Vickram Tejwani, Ashraf Fawzy, Nirupama Putcha, Peter J. Castaldi, Michael H. Cho, Katherine A. Pratte, Surya P. Bhatt, David A. Lynch, Stephen M. Humphries, Gregory L. Kinney, Franco R. D’Alessio, Nadia N. Hansel, James D. Crapo, Edwin K. Silverman, Barry J. Make, Elizabeth A. Regan, Terri Beaty, Ferdouse Begum, Michael Cho, Dawn L. DeMeo, Adel R. Boueiz, Marilyn G. Foreman, Eitan Halper-Stromberg, Lystra P. Hayden, Craig P. Hersh, Jacqueline Hetmanski, Brian D. Hobbs, John E. Hokanson, Nan Laird, Christoph Lange, Sharon M. Lutz, Merry-Lynn McDonald, Margaret M. Parker, Dmitry Prokopenko, Dandi Qiao, Phuwanat Sakornsakolpat, Emily S. Wan, Sungho Won, Juan Pablo Centeno, Jean-Paul Charbonnier, Harvey O. Coxson, Craig J. Galban, MeiLan K. Han, Eric A. Hoffman, Stephen Humphries, Francine L. Jacobson, Philip F. Judy, Ella A. Kazerooni, Alex Kluiber, Pietro Nardelli, John D. Newell, Aleena Notary, Andrea Oh, James C. Ross, Raul San Jose Estepar, Joyce Schroeder, Jered Sieren, Berend C. Stoel, Juerg Tschirren, Edwin Van Beek, Bramvan Ginneken, Eva van Rikxoort, Gonzalo Vegas Sanchez-Ferrero, Lucas Veitel, George R. Washko, Carla G. Wilson, Robert Jensen, Douglas Everett, Jim Crooks, Katherine Pratte, Matt Strand, Gregory Kinney, Kendra A. Young, Jessica Bon, Alejandro A. Diaz, Barry Make, Susan Murray, Elizabeth Regan, Xavier Soler, Russell P. Bowler, Katerina Kechris, Farnoush Banaei-Kashani, Jeffrey L. Curtis, Perry G. Pernicano, Nicola Hanania, Mustafa Atik, Aladin Boriek, Kalpatha Guntupalli, Elizabeth Guy, Amit Parulekar, Craig Hersh, George Washko, R. Graham Barr, John Austin, Belinda D’Souza, Byron Thomashow, Neil MacIntyre, H. Page McAdams, Lacey Washington, Eric Flenaugh, Silanth Terpenning, Charlene McEvoy, Joseph Tashjian, Robert Wise, Robert Brown, Karen Horton, Allison Lambert, Richard Casaburi, Alessandra Adami, Matthew Budoff, Hans Fischer, Janos Porszasz, Harry Rossiter, William Stringer, Amir Sharafkhaneh, Charlie Lan, Christine Wendt, Brian Bell, KenM. Kunisaki, Russell Bowler, Richard Rosiello, David Pace, Gerard Criner, David Ciccolella, Francis Cordova, Chandra Dass, Gilbert D’Alonzo, Parag Desai, Michael Jacobs, Steven Kelsen, Victor Kim, A. James Mamary, Nathaniel Marchetti, Aditi Satti, Kartik Shenoy, Robert M. Steiner, Alex Swift, Irene Swift, Maria Elena Vega-Sanchez, Mark Dransfield, William Bailey, Anand Iyer, Hrudaya Nath, J. Michael Wells, Douglas Conrad, Andrew Yen, Alejandro P. Comellas, Karin F. Hoth, John Newell, Brad Thompson, Ella Kazerooni, Wassim Labaki, Craig Galban, Dharshan Vummidi, Joanne Billings, Abbie Begnaud, Tadashi Allen, Frank Sciurba, Divay Chandra, Carl Fuhrman, and Joel Weissfeld

Subjects
Pulmonary and Respiratory Medicine, Male, Angiotensin receptor, medicine.medical_specialty, Population, Vital Capacity, Angiotensin-Converting Enzyme Inhibitors, Walk Test, Critical Care and Intensive Care Medicine, Cohort Studies, 03 medical and health sciences, Angiotensin Receptor Antagonists, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Internal medicine, Forced Expiratory Volume, Medicine, Humans, cardiovascular diseases, 030212 general & internal medicine, Prospective Studies, education, Aged, COPD, education.field_of_study, Lung, biology, business.industry, Angiotensin-converting enzyme, respiratory system, Middle Aged, Protective Factors, medicine.disease, Angiotensin II, respiratory tract diseases, medicine.anatomical_structure, 030228 respiratory system, Genetic epidemiology, Pulmonary Emphysema, Spirometry, Cohort, biology.protein, Cardiology, Disease Progression, Female, Cardiology and Cardiovascular Medicine, business, Lung Volume Measurements, Tomography, X-Ray Computed
Abstract

Background Attenuation of transforming growth factor β by blocking angiotensin II has been shown to reduce emphysema in a murine model. General population studies have demonstrated that the use of angiotensin converting enzyme inhibitors (ACEis) and angiotensin-receptor blockers (ARBs) is associated with reduction of emphysema progression in former smokers and that the use of ACEis is associated with reduction of FEV1 progression in current smokers. Research Question Is use of ACEi and ARB associated with less progression of emphysema and FEV1 decline among individuals with COPD or baseline emphysema? Methods Former and current smokers from the Genetic Epidemiology of COPD Study who attended baseline and 5-year follow-up visits, did not change smoking status, and underwent chest CT imaging were included. Adjusted linear mixed models were used to evaluate progression of adjusted lung density (ALD), percent emphysema (%total lung volume Results Over 5 years of follow-up, compared with nonusers, ACEi and ARB users with COPD showed slower ALD progression (adjusted mean difference [aMD], 1.6; 95% CI, 0.34-2.9). Slowed lung function decline was not observed based on phase 1 medication (aMD of FEV1 % predicted, 0.83; 95% CI, –0.62 to 2.3), but was when analysis was limited to consistent ACEi and ARB users (aMD of FEV1 % predicted, 1.9; 95% CI, 0.14-3.6). No effect modification by smoking status was found for radiographic outcomes, and the lung function effect was more pronounced in former smokers. Results were similar among participants with baseline emphysema. Interpretation Among participants with spirometry-confirmed COPD or baseline emphysema, ACEi and ARB use was associated with slower progression of emphysema and lung function decline. Trial Registry ClinicalTrials.gov ; No.: NCT00608764; URL: www.clinicaltrials.gov

Published
2020

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