5 results on '"Pedro Pablo España"'
Search Results
2. Community-Acquired Pneumonia Patients at Risk for Early and Long-term Cardiovascular Events Are Identified by Cardiac Biomarkers
- Author
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Rosario Menéndez, Paula González-Jiménez, Ricardo Alonso, Raúl Méndez, Marta Suescun, Jordi Almirall, Soledad Reyes, Antoni Torres, Pedro Pablo España, Luis Martínez-Dolz, and Irene Aldás
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Pulmonary and Respiratory Medicine ,Male ,medicine.medical_specialty ,Time Factors ,medicine.drug_class ,Critical Care and Intensive Care Medicine ,Risk Assessment ,Procalcitonin ,03 medical and health sciences ,0302 clinical medicine ,Community-acquired pneumonia ,Internal medicine ,Natriuretic peptide ,Pneumonia, Bacterial ,Medicine ,Humans ,030212 general & internal medicine ,Myocardial infarction ,Prospective Studies ,Aged ,Aged, 80 and over ,biology ,Troponin T ,business.industry ,C-reactive protein ,Middle Aged ,medicine.disease ,Troponin ,Community-Acquired Infections ,Pneumonia ,030228 respiratory system ,Cardiovascular Diseases ,biology.protein ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers - Abstract
Background Community-acquired pneumonia (CAP) increases the risk of cardiovascular complications during and following the episode. The goal of this study was to determine the usefulness of cardiovascular and inflammatory biomarkers for assessing the risk of early (within 30 days) or long-term (1-year follow-up) cardiovascular events. Methods A total of 730 hospitalized patients with CAP were prospectively followed up during 1 year. Cardiovascular (proadrenomedullin [proADM], pro-B-type natriuretic peptide (proBNP), proendothelin-1, and troponin T) and inflammatory (interleukin 6 [IL-6], C-reactive protein, and procalcitonin) biomarkers were measured on day 1, at day 4/5, and at day 30. Results Ninety-two patients developed an early event, and 67 developed a long-term event. Significantly higher initial levels of proADM, proendothelin-1, troponin, proBNP, and IL-6 were recorded in patients who developed cardiovascular events. Despite a decrease at day 4/5, levels remained steady until day 30 in those who developed late events. Biomarkers (days 1 and 30) independently predicted cardiovascular events adjusted for age, previous cardiac disease, Pa o 2/F io 2 Conclusions Cardiac biomarkers are useful for identifying patients with CAP at high risk for early and long-term cardiovascular events. They may aid personalized treatment optimization and for designing future interventional studies to reduce cardiovascular risk.
- Published
- 2019
3. Pneumonia
- Author
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Pedro Pablo España, Inmaculada Gorordo, Alberto Capelastegui, Marimar Martinez-Vazquez, Isabel Urrutia, José M. Quintana, Mikel Oribe, and Amaia Bilbao
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,Proportional hazards model ,Pneumonia severity index ,Mortality rate ,Hazard ratio ,Critical Care and Intensive Care Medicine ,medicine.disease ,CURB-65 ,Pneumonia ,Severity of illness ,Emergency medicine ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Intensive care medicine ,Prospective cohort study - Abstract
Background A study was undertaken to identify and weigh at the time of hospital discharge simple clinical variables that could predict short-term outcomes in patients with pneumonia. Methods In a prospective observational cohort study of 870 patients discharged alive after hospitalization for pneumonia, we collected oxygenation and vital signs on discharge and assessed mortality and readmission within 30 days. From the β-parameter obtained in a multivariate Cox proportional hazard regression model, a score was assigned to each predictive variable. The effects of instability at discharge on outcomes within 30 days thereafter were examined by adjusted models with use of the pneumonia severity index at hospital admission, the length of stay, the Charlson comorbidity index, or the preillness functional status. Results Four variables related to a 30-day mortality rate from all causes were identified in the multivariate model; these included one major criterion (temperature >37.5°C) and three minor criteria (systolic BP 24 breaths/min, and oxygen saturation Conclusions Four criteria of instability on discharge seem to be related to the mortality rate after discharge, but each of the factors must be weighed differently. The resulting score is a simple alternative that can be used by clinicians in the discharge process.
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- 2008
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4. Predictive Power of Inflammatory Biomarkers in the Short-term Mortality in Pneumonia
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Helena Azcuna, Rosa Diez, Alberto Capelastegui, Ane Uranga, Sandra Dorado, Urko Aguirre, Pedro Pablo España, Maria del Carmen Mar, and Edurne Bereciartua
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Pneumonia ,business.industry ,Predictive power ,Short term mortality ,Medicine ,Cardiology and Cardiovascular Medicine ,Critical Care and Intensive Care Medicine ,business ,Intensive care medicine ,medicine.disease ,Inflammatory biomarkers - Published
- 2014
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5. Sequential evaluation of serum adenosine deaminase in patients treated for tuberculosis
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Fernando Izquierdo, Jose Mayo, Julio Collazos, Pedro Pablo España, and Eduardo Martínez
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Pulmonary and Respiratory Medicine ,Adult ,Male ,medicine.medical_specialty ,Tuberculosis ,Adolescent ,Adenosine Deaminase ,medicine.medical_treatment ,Antitubercular Agents ,Critical Care and Intensive Care Medicine ,Gastroenterology ,Adenosine deaminase ,Internal medicine ,medicine ,Isoniazid ,Outpatient clinic ,Humans ,Tuberculosis, Pulmonary ,Chemotherapy ,Lung ,biology ,business.industry ,Respiratory disease ,Tuberculosis, Pleural ,Pyrazinamide ,Middle Aged ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Treatment Outcome ,biology.protein ,Drug Therapy, Combination ,Female ,Rifampin ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers ,medicine.drug ,Follow-Up Studies - Abstract
Study objectives To delineate the course of serum adenosine deaminase (s-ADA) in patients with tuberculosis who are receiving effective therapy. Setting A medical ward and an outpatient clinic in a general hospital. Patients Twenty-five immunocompetent patients with pleural or pulmonary tuberculosis. Interventions All patients received standard chemotherapeutic regimens with isoniazid, rifampin, and pyrazinamide. Measurements and results Six measurements of several variables, including s-ADA, were carried out at different periods of time during the 6 months of follow-up. There were no significant differences in s-ADA values between sexes and there was no significant correlation with age or with the other variables analyzed. There was a significant decline in the s-ADA values during the first 2 months in the patients as a whole (p=0.04), followed by a stabilization of the s-ADA activity. This decline was due to a marked decrease in the s-ADA in the 13 patients (52%) who had initial high levels of the enzyme (p=0.03), whereas there were no changes in those patients with normal initial levels (p=0.27). Patients with increased s-ADA activity at the time of the first measurement reported symptoms for a longer period than patients with normal s-ADA (median, 15 vs 10 days; p=0.02). Conclusions s-ADA levels in patients with tuberculosis decrease during the initial months of effective treatment. Perhaps this decrease might reflect the normalization of the altered lymphocyte turnover induced by tuberculosis. The measurement of s-ADA could be of some help to evaluate the response to therapy, particularly in those patients with increased values of the enzyme.
- Published
- 1998
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